Group B streptococcal disease in infants in the first year of life: a nationwide surveillance study in Japan, 2011–2015

Abstract

CFR of EOD and LOD in Japan is comparable with that in high-income European countries or the United States, and their incidence is much lower. Our findings also describe the clinical details of LLOD, recurrent infections, and infections in twin siblings. This study is the largest among Asian childhood GBS studies ever reported.

Group B Streptococcal Meningitis in the First Year of Life: A Nationwide Surveillance Study in Cuba, 1998-2016

“…In the present research EOD was infrequent compared with LOD and YID, contrarily to results in an extensive surveillance research in Japan [20] where EOD accounted near 80.00 %. The number of LOD peaked at the age of 18 days, coincident with other authors [20]. The YID burden was around one third of the total and most cases occur near two month of age.…”

“…Southeast Asia shows the lowest rates of incidence [19]. In the present research EOD was infrequent compared with LOD and YID, contrarily to results in an extensive surveillance research in Japan [20] where EOD accounted near 80.00 %. The number of LOD peaked at the age of 18 days, coincident with other authors [20].…”

“…The YID burden was around one third of the total and most cases occur near two month of age. High income countries report less GBS meningitis burden and most cases at 3 months of birth [20][21][22]. Low figures of EOD in Cuba might be related with nationwide implementation strategy for the management of vaginal discharge syndrome in pregnant women and their partners, with full and free accessibility to effective drugs in healthcare facilities [23] and need further confirmation.…”

Universal antenatal screening for group B streptococcus may cause more harm than good

“…Affected neonates present with sepsis in 63% of cases, pneumonia in 24%, meningitis in 13%,29 and around 5-10% (n=27-38) die as a result 302. Neurological impairment is reported in up to 16% of cases who survive infection,313233 though long term outcomes are not well researched. The true burden of early onset GBS infection is likely to be higher, as most of the research only describes cases confirmed by culture, and the infecting organism cannot be isolated in approximately half of neonatal sepsis cases 34.…”

“…Number of cases of early onset infection and mortality taken from the British Paediatric Surveillance Unit study 293039. Long term disability: 8.7-15.8% of surviving early onset cases 313233. Short term early onset GBS infection morbidity: meningitis 13.2%, sepsis 63.1%, pneumonia 23.7% 29.…”