Group B Streptococcus Colonization in Late Pregnancy and Invasive Infection in Neonates in China: A Population-Based 3-Year Study

Zhu, Yueyong; Huang, Jing; Lin, Xin-Zhu; Chen, Chao

doi:10.1159/000494133

Cited by 21 publications

(26 citation statements)

References 13 publications

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“…The prevalence rates of GBS colonization vary in different geographical regions across the globe. This study showed similar results to those of other studies in Saudi Arabia [ 26 ], Tunisia [ 27 ], and China [ 28 ]. However, studies from Kuwait [ 29 ], Morocco [ 30 ], Iran [ 31 ], Turkey [ 32 ], and Ethiopia [ 33 ] reported higher prevalence rates than those found in this study.…”

Section: Discussionsupporting

confidence: 92%

Prevalence and Risk Factors of Group B Streptococcus Colonization in Pregnant Women: A Pilot Study in Palestine

Qadi

AbuTaha

Al-Shehab

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Maternal Streptococcus agalactiae (Group B Streptococcus (GBS)) colonization is an important cause of complications in mothers and neonates during gestation and after delivery. The data regarding GBS colonization among pregnant women in Palestine is scarce. The aim of this study is to determine the prevalence of GBS colonization, its associated risk factors, and the antibiotic sensitivity patterns in Nablus, West Bank, Palestine. Methods. A cross-sectional, single center study conducted at Rafidia Governmental Hospital in Nablus, West Bank, Palestine. Samples were collected between November 2019 and January 2020. Vaginal swabs from 200 pregnant women (≥35 weeks of gestation) attending the labor and delivery department were plated directly on CHROMagarTM StrepB (CHROM agar, France) and placed in an incubator at 35–37°C. After 24 and 48 hours, the plates were checked for growth and classified into three categories: growth of GBS with mauve colonies on chromogenic media, no growth, or other growth. The identification of the mauve colonies was confirmed by the CAMP test. Identified GBS isolates were tested for susceptibility to vancomycin, ampicillin, clindamycin, cefotaxime, erythromycin, and levofloxacin using the disc diffusion method. Clinical and demographic information were collected using a questionnaire. Result. The overall prevalence of GBS colonization was 12%. The median age of the study population was 27 years. GBS colonization was significantly associated with age ( p = 0.013 ), history of previous preterm delivery ( p = 0.013 ), and parity ( p = 0.015 ). No association was noted with smoking, previous abortion, previous history of fetal demise, vaginitis, or urinary tract infection. Resistance to ampicillin, vancomycin, cefotaxime, erythromycin, clindamycin, and levofloxacin was found to be 91.7%, 54.2%, 45.8%, 29.2%, 25%, and 8.3%, respectively. Conclusion. The prevalence of vaginal GBS in this study was 12% from Nablus, West Bank. Further research is needed to determine the GBS serotypes common in West Bank and the burden they cause on the health system. Moreover, this study also highlights the need to establish a screening program suited to a developing country with low control on the antibiotic’s prescription protocols.

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Section: Discussionsupporting

confidence: 92%

Prevalence and Risk Factors of Group B Streptococcus Colonization in Pregnant Women: A Pilot Study in Palestine

Qadi

AbuTaha

Al-Shehab

et al. 2021

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…En el presente estudio la frecuencia de colonización (4.3%) fue menor que la reportada en el mundo (17.9%, intervalo de confianza del 95% [IC 95%]: 16.2-19.7%) 22 , con un rango del 11.1% (IC 95%: 6.8-15.3%) en el sudeste asiático al 22.4% en África (IC 95%: 18.1-26.7%). Algunos países como Brasil (14%), China (14%), Nigeria (19.5%) y Arabia Saudita (19%) tienen una frecuencia alta [22][23][24][25][26][27] . En México también hay diferencias con estudios previos realizados: Collado, et al en 1981 encontraron un 4% de colonización 10 , sin embargo, en un centro de atención de tercer nivel en la CDMX se reportó un 10.3%, en una población rural del sur del país encontraron un 8.6% 12 y en un hospital de segundo nivel en el occidente de México un 13% 13 .…”

Section: Discussionunclassified

“…Quizá las diferencias el presente estudio podría explicarse por el tamaño de muestra y que el muestreo fue en mujeres embarazadas que estaban en TP, recién ingresadas y la mayoría con embarazos a término. La colonización por SGB fue mayor en mujeres con embarazo de alto riesgo, esta frecuencia aumenta a mayor edad, sin embargo, esta frecuencia es menor que la observada en otras poblaciones del mundo [22][23][24][25][26][27] .…”

Section: Discussionunclassified

Colonización cervicovaginal y rectal por estreptococos del grupo B en embarazadas mexicanas a término

Cabrera-Reyes¹,

Martínez-García²,

Palacios-Saucedo³

et al. 2021

GMM

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Antecedentes: Una mujer embarazada colonizada por estreptococo del grupo B por vía rectal o vaginal puede infectar a su recién nacido. Pacientes y métodos: Estudio prospectivo, transversal y analítico, durante 24 meses, en embarazadas. Se incluyeron aquellas en trabajo de parto con ≥ 36 semanas de gestación. El embarazo se clasificó como normal o de alto riesgo. Se analizaron los principales factores de riesgo de las embarazadas. Se tomaron muestras rectales y vaginales, se colocaron en caldo Todd-Hewitt y posteriormente se inocularon en agar sangre de carnero al 5%. La identificación se realizó mediante pruebas bioquímicas y aglutinación con látex. Resultados: Se incluyeron 3,347 embarazadas, edad media 25.6 ± 5.3 años, 95.5% con control prenatal; 2,213 (66%) embarazo de riesgo normal y 1,370 (41%) obtenidas por cesárea. La colonización global fue del 4.3% (145/3,347), siendo mayor en el grupo de edad de 30 a 34 años (6.8%). El serotipo I (58%) fue el más frecuente. Conclusión: El porcentaje de colonización en esta población fue bajo. Un programa sistemático de cultivo cervicovaginal y rectal en mujeres embarazadas y el programa de profilaxis antimicrobiana intraparto son controvertidos en nuestra región.

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“…27 A GBS-EOD incidence rate of 1.48 per 1000 live births was reported in Xiamen, Fujian Province, which was higher than other regions of China. 28 On the basis of the composition of capsular polysaccharide (CPS), GBS isolates can be divided into ten CPS serotypes (Ia, Ib, and II-IX). A meta-analysis on the serotype distribution of maternal GBS colonization showed that serotype III, the most prevalent, accounted for 25% of serotypes globally.…”

Section: Epidemiology Of Perinatal Gbs Infection In Mainland Chinamentioning

confidence: 99%

Updates in prevention policies of early-onset group B streptococcal infection in newborns

Zhu

Lin

2021

Pediatrics & Neonatology

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Invasive disease owing to group B Streptococcus (GBS) is a major cause of illness and death among newborns. Maternal GBS colonization of gastrointestinal tract and/or vagina is the primary risk factor for neonatal GBS early-onset disease (EOD). In Europe and America, there are marked declines in neonatal GBS-EOD through widespread implementation of guidelines for maternal GBS screening and subsequent intrapartum antibiotic prophylaxis (IAP). The key measures necessary for prevention of GBS-EOD include correct specimen collection and processing, nucleic acid amplification testing (NAAT) for GBS identification, regimens for mothers with premature rupture of membranes (PROM), preterm labor or penicillin allergy, and coordination between obstetrics and pediatrics. Antibiotic prophylaxis has some disadvantages, so researchers should develop other preventive measures. Maternal vaccines to prevent perinatal GBS infection are currently under development. However, as large, population-based sampling studies are rarely conducted, the colonization rate and the disease burden of GBS in perinatal period are poorly understood in developing countries. The harm of GBS to newborns has been recognized in recent years in mainland China, but authorized prevention measures are still lacking. In order to enhance the understanding of GBS-EOD prevention, the most recent guidelines updates by the American College of Obstetricians and Gynecologists (ACOG) and American Academy of Pediatrics (AAP) in 2019e2020 are summarized in this article.

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Group B Streptococcus Colonization in Late Pregnancy and Invasive Infection in Neonates in China: A Population-Based 3-Year Study

Cited by 21 publications

References 13 publications

Prevalence and Risk Factors of Group B Streptococcus Colonization in Pregnant Women: A Pilot Study in Palestine

Prevalence and Risk Factors of Group B Streptococcus Colonization in Pregnant Women: A Pilot Study in Palestine

Colonización cervicovaginal y rectal por estreptococos del grupo B en embarazadas mexicanas a término

Updates in prevention policies of early-onset group B streptococcal infection in newborns

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