Grover's Disease: Clinicopathologic Review of 72 Cases

Davis, Mark D.P.; Dinneen, Annette M.; Landa, N.; Gibson, Lawrence E.

doi:10.4065/74.3.229

Cited by 84 publications

(78 citation statements)

References 24 publications

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“…An association with excessive heat, sweating and xerosis is postulated [13], while paraneoplasia is rejected [12]. The predisposing conditions, the site of involvement and the relapsing nature of the disorder may implicate an acrosyringeal dysfunction as the cause [14, 15]. Well-documented induction by drugs has not been reported so far.…”

Section: Discussionmentioning

confidence: 99%

Grover’s Disease Induced by Cetuximab

Tscharner¹,

Bühler²,

Borner³

et al. 2006

Dermatology

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A 71-year-old man exhibited an acute acneiform rash affecting the face and the upper trunk about 2 weeks after starting cetuximab, an epidermal growth factor (EGF) receptor antagonist treatment for metastatic colon cancer. The skin eruption faded after stopping cetuximab and applying topical corticosteroids. The reexposure to cetuximab 3 weeks later provoked a more extended relapse of the skin rash, which then clinically and histologically corresponded to transient acantholytic dermatosis . While the acneiform cutaneous side effects of the EGF receptor antagonists are interpreted as a result of the direct interference with pilosebaceous follicle homeostasis, in this case an acrosyringium-related pathogenesis might be postulated. Applying topical corticosteroids and emollients, the cetuximab therapy could be pursued.

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Section: Discussionmentioning

confidence: 99%

Grover’s Disease Induced by Cetuximab

Tscharner¹,

Bühler²,

Borner³

et al. 2006

Dermatology

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“…It is remarkable that a dermal lymphocytic infiltrate with eosinophils in Grover’s disease is found in only up to 22% of cases [3]. On the other hand, an inflammatory infiltrate with eosinophils is a constant histopathologic finding in scabies.…”

Section: Discussionmentioning

confidence: 99%

“…For example, some authors have proposed sweat retention to be crucial for the development of lesions of Grover’s disease [3, 4, 5, 9]. According to these investigators, sweat and heat may favour a loss of keratinocyte cohesion due to enzyme liberation and thereby lead to keratinocyte acantholysis, a histopathologic hallmark of Grover’s disease.…”

Section: Discussionmentioning

confidence: 99%

“…Grover’s disease is a recurrent, transient or persistent acantholytic skin condition characterised clinically by discrete, pruritic papules and papulovescicles distributed mainly on the trunk and histopathologically by focal acantholysis and/or spongiosis [1, 2, 3, 4]. The aetiology and pathogenesis of Grover’s disease is still unclear, but a number of local and systemic causative or triggering factors have previously been linked with the development of this condition [2, 3, 5].…”

Section: Introductionmentioning

confidence: 99%

“…The aetiology and pathogenesis of Grover’s disease is still unclear, but a number of local and systemic causative or triggering factors have previously been linked with the development of this condition [2, 3, 5]. Recently, Köstler [6]and Jordaarn et al [7]have described 2 patients with cutaneous lesions fulfilling the clinical and histopathologic features of Grover’s disease in which mites of Sarcoptes scabiei were demonstrated.…”

Section: Introductionmentioning

confidence: 99%

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Grover’s Disease Associated with <i>Sarcoptes scabiei</i>

2001

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An 83-year-old man presented with a 4-month history of discrete, itchy papules mainly distributed on the trunk and upper extremities. Histopathologic examination of two biopsies from lesions on the trunk revealed mainly focal suprabasal acantholysis and an inflammatory infiltrate composed mainly of lymphocytes with a few eosinophils. The overall clinical and histopathologic features were consistent with Grover’s disease. However, scrapings taken from the skin lesions showed numerous mites of Sarcoptes scabiei. Subsequent treatment with an antiscabies cream led to a rapid complete cure, and no skin lesions have been observed during a 6-month follow-up. A review of the literature revealed 2 other cases of cutaneous lesions fulfilling the clinical and histopathologic features of Grover’s disease in which mites of S. scabiei were demonstrated. Our observation further highlights the unusual association of Grover’s disease with S. scabiei mites and emphasises the importance of excluding this easily treatable skin infestation in all patients with Grover’s disease.

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Association of Somatic ATP2A2 Damaging Variants With Grover Disease

Seli,

Ellis,

Goldust

et al. 2023

JAMA Dermatol

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ImportanceGrover disease (GD), a truncal eruption that typically occurs in older individuals, is exacerbated by sweating, irradiation, cancers, medications, kidney failure, and organ transplantation. The pathobiology of GD remains unknown.ObjectiveTo determine if damaging somatic single-nucleotide variants (SNVs) are associated with GD.Design, Setting, and ParticipantsIn this retrospective case series, we identified consecutive patients from a dermatopathology archive over a 4-year period (January 2007 to December 2011) who had 1 biopsy with a clinical diagnosis of GD confirmed via histopathologic findings and another non-GD biopsy. Participant DNA was extracted from both biopsy tissues and sequenced to high depth with a 51-gene panel to screen for SNVs in genes previously associated with acantholysis and Mendelian disorders of cornification. Analysis took place between 2021 and 2023.Main Outcomes and MeasuresComparative analysis of sequencing data from paired GD and control tissue was employed to identify SNVs predicted to affect gene function, which were exclusive to, or highly enriched in, GD tissue.ResultsOverall, 12 of 15 cases of GD (12 men and 3 women; mean [SD] age, 68.3 [10.0] years) were associated with C&gt;T or G&gt;A ATP2A2 SNVs in GD tissue; all were predicted to be highly damaging via combined annotation dependent depletion (CADD) scores, and 4 were previously associated with Darier disease. In 9 cases (75%), the GD-associated ATP2A2 SNV was absent from control tissue DNA, and in 3 cases (25%), ATP2A2 SNVs were enriched 4- to 22-fold in GD vs control tissue.Conclusions and RelevanceIn this case series study of 15 patients, damaging somatic ATP2A2 SNVs were associated with GD. This discovery expands the spectrum of acantholytic disorders associated with ATP2A2 SNVs and highlights the role of somatic variation in acquired disorders.

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Grover's Disease: Clinicopathologic Review of 72 Cases

Cited by 84 publications

References 24 publications

Grover’s Disease Induced by Cetuximab

Grover’s Disease Induced by Cetuximab

Grover’s Disease Associated with <i>Sarcoptes scabiei</i>

Association of Somatic ATP2A2 Damaging Variants With Grover Disease

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