Growing up with your airway microbiota: a risky business

Ahmed, B.; Cox, Michael J.; Cuthbertson, Leah

doi:10.1136/thoraxjnl-2019-213162

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Other higher resolution methods for microbiota profiling are currently being used to disclose the functional link between the lungs and its microbiota [7]. The growing interest in the relationship between the microbial population and the human body accounts for the large amount of published papers on the topic in recent years [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The lung microbiome: clinical and therapeutic implications

et al. 2019

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The human respiratory tract, usually considered sterile, is currently being investigated for human-associated microbial communities. According to Dickson's conceptual model, the lung microbiota (LMt) is a dynamic ecosystem, whose composition, in healthy lungs, is likely to reflect microbial migration, reproduction, and elimination. However, which microbial genera constitutes a "healthy microbiome" per se remains hotly debated. It is now widely accepted that a bi-directional gut-lung axis connects the intestinal with the pulmonary microbiota and that the diet could have a role in modulating both microbiotas as in health as in pathological status. The LMt is altered in numerous respiratory disorders such as obstructive airway diseases, interstitial lung diseases, infections, and lung cancer. Some authors hypothesize that the use of specific bacterial strains, termed "probiotics," with positive effects on the host immunity and/or against pathogens, could have beneficial effects in the treatment of intestinal disorders and pulmonary diseases. In this manuscript, we have reviewed the literature available on the LMt to delineate and discuss the potential relationship between composition alterations of LMt and lung diseases. Finally, we have reported some meaningful clinical studies that used integrated probiotics' treatments to contrast some lung-correlated disorders.

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Section: Introductionmentioning

confidence: 99%

The lung microbiome: clinical and therapeutic implications

et al. 2019

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“…Personalized treatments based on risk stratification by the dominant organism in the microbiota may be beneficial [63]. As we have already described [33], differences in the microbiota composition between healthy and exacerbation are illustrated in Figure 1.…”

Section: Microbiota Dysbiosis and Chronic Obstructive Pulmonary Diseasementioning

confidence: 91%

May nutrients and dietary supplements influence the gut-lung microbiota axis in chronic obstructive pulmonary disease and exacerbations?

Conte

Toraldo²

2020

Arch Med Sci

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There is increasing evidence that microbial community structure and diversity are associated with disease severity and clinical outcomes, both in stable chronic obstructive pulmonary disease (COPD) and in exacerbations. New evidence has confirmed that the gut-lung axis-the cross-talk between the gut and the lung-is a bi-directional condition that is a continuous blood communication between the two sits that, in this way, would be able to modulate each other's local immune response and the composition of the respective microbiota. However, although it is clear that the gut microbiota influences inflammation in the peripheral system, what happens in the lung is still poorly understood. As malnutrition is an important factor in COPD, nutritional support might be a strong component of disease management and prevention. In this review, we tried to elucidate the role of diet and dietary supplementation affecting the lung microbiota with respect to stable COPD and exacerbation.

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Growing up with your airway microbiota: a risky business

Cited by 2 publications

References 20 publications

The lung microbiome: clinical and therapeutic implications

The lung microbiome: clinical and therapeutic implications

May nutrients and dietary supplements influence the gut-lung microbiota axis in chronic obstructive pulmonary disease and exacerbations?

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