Growrth hormone secretion and circulating insulin-like growth factor-I (IGF-I) and IGF binding protein-3 concentrations in children with sickle cell disease

Soliman, Ashraf T.; Banna, Nagwa El; Salmi, Issa Al; Silva, Vasantha De; Craig, A.; M, Asfour

doi:10.1016/s0026-0495(97)90224-9

Cited by 29 publications

(27 citation statements)

References 33 publications

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“…Poor growth and poor nutritional status are common clinical features of SCD particularly in persons with type SS (SCA) [22]. Some of factors that have been suggested to account for the growth deficit in SCD include tissue hypoxia caused by severe anemia and associated increase in energy expenditure, adverse effects of vaso-occlusion, endocrine dysfunction, and chronic organ damage [23]. Data also showed that body fat% and fat mass were significantly higher in SCD children.…”

Section: Discussionmentioning

confidence: 99%

Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease

2006

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The current studies aimed at determining physical fitness indices and anthropometrics profiles of school children with sickle cell trait (SCT) and sickle cell disease (SCD). Male school children (150) comprising 3 Groups participated in the studies. Group 1 has 50 normal healthy controls, while Groups 2 and 3 each has 50 children who were suffering from SCT and SCD, respectively. Anthropometrics measurement and parameters of physical fitness were assessed in all subjects. All children were also subjected to a 5-min running exercise test on a flat motorized treadmill at speed corresponding to 5 km/hr. Throughout the test, heart rate was monitored and recoded during exercise and for 10-min during recovery. Blood lactate was measured before and 5 min following the completion of test. The mean values of lean body mass and height were lower in the SCD children (P < 0.05) compared with the healthy subjects and SCT individuals. Children with SCD exhibited a higher mean value (P < 0.05) for percent body fat and fat mass than the normal healthy subjects and SCT individuals. Although all groups tolerated well the treadmill exercise protocol, the SCD group exhibited higher (P < 0.05) mean values of heart rate during exercise than those observed in the SCT and normal control children. In addition, SCD children showed higher serum lactate values before and after treadmill exercise compared to the other groups. Children with SCD exhibit high level of adiposity; low level of fitness and their exercise performance appears to be physiologically more stressful as indicated by heart rate and blood lactate concentration responses. Am. J. Hematol. 82:91-97, 2007. V V C 2006 Wiley-Liss, Inc.

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Section: Discussionmentioning

confidence: 99%

Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease

2006

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“…Abnormalities in gonadotropin secretion patterns (elevated luteinizing hormone and depressed follicle-stimulating hormone in early puberty) in boys and girls with SCD (19) and poor testosterone response to gonadotrophin-releasing hormone in some boys (20) suggest impairments in the regulatory feedback mechanisms of the hypothalamic-pituitary-gonadal axis leading to sexual maturity. Growth hormone abnormalities have also been reported (21)(22)(23).…”

Section: Growth Failure In Sickle Cell Diseasementioning

confidence: 92%

Effects of Delayed Pubertal Development, Nutritional Status, and Disease Severity on Longitudinal Patterns of Growth Failure in Children With Sickle Cell Disease

et al. 2007

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“…88 Interest in growth hormone dysfunction has motivated a series of studies by Soliman and co-workers who demonstrated abnormalities in the growth hormone (GH)/insulinlike growth factor-I (IGF-I) axis. 54,[89][90][91][92] In a study of 21 pre-pubertal SS children with poor growth (height ,10th centile), defective GH secretion and low insulin-like IGF-1 and IGF binding-protein-3 were demonstrated in 43%, with a reduced response of IGF-1 production to GH injection. The disease severity score was significantly higher in the group with defective GH secretion than in the group with normal GH secretion.…”

Section: Endocrine Dysfunction and Growth Retardationmentioning

confidence: 99%

Growth and nutritional status of children with homozygous sickle cell disease

Al-Saqladi

Cipolotti

Fijnvandraat

et al. 2008

Annals of Tropical Paediatrics

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Background: Poor growth and under-nutrition are common in children with sickle cell disease (SCD). This review summarises evidence of nutritional status in children with SCD in relation to anthropometric status, disease severity, body composition, energy metabolism, micronutrient deficiency and endocrine dysfunction. Methods: A literature search was conducted on the Medline/PUBMED, SCOPUS, SciELO and LILACS databases to July 2007 using the keywords sickle cell combined with nutrition, anthropometry, growth, height and weight, body mass index, and specific named micronutrients. Results: Forty-six studies (26 cross-sectional and 20 longitudinal) were included in the final anthropometric analysis. Fourteen of the longitudinal studies were conducted in North America, the Caribbean or Europe, representing 78.8% (2086/2645) of patients. Most studies were observational with wide variations in sample size and selection of reference growth data, which limited comparability. There was a paucity of studies from Africa and the Arabian Peninsula, highlighting a large knowledge gap for low-resource settings. There was a consistent pattern of growth failure among affected children from all geographic areas, with good evidence linking growth failure to endocrine dysfunction, metabolic derangement and specific nutrient deficiencies. Conclusions: The monitoring of growth and nutritional status in children with SCD is an essential requirement for comprehensive care, facilitating early diagnosis of growth failure and nutritional intervention. Randomised controlled trials are necessary to assess the potential benefits of nutritional interventions in relation to growth, nutritional status and the pathophysiology of the disease.

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Growrth hormone secretion and circulating insulin-like growth factor-I (IGF-I) and IGF binding protein-3 concentrations in children with sickle cell disease

Cited by 29 publications

References 33 publications

Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease

Physical fitness indices and anthropometrics profiles in schoolchildren with sickle cell trait/disease

Effects of Delayed Pubertal Development, Nutritional Status, and Disease Severity on Longitudinal Patterns of Growth Failure in Children With Sickle Cell Disease

Growth and nutritional status of children with homozygous sickle cell disease

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