Growth and Development of the Rabbit Brain

Harel, Shaul; Watanabe, K.; Linke, I; Schain, Richard J.

doi:10.1159/000240527

Cited by 126 publications

(57 citation statements)

References 22 publications

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“…In the present study, the cross-sectional area of the midcerebrum increased 3-to 4-fold postnatally. This corresponds well with the 5-to 7-fold increase in brain weight reported by others (12,13).…”

Section: Discussionsupporting

confidence: 92%

Local Cerebral Blood Flow in the Newborn Rabbit: An Autoradiographic Study of Changes during Development

Tuor

1991

Pediatr Res

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Section: Discussionsupporting

confidence: 92%

Local Cerebral Blood Flow in the Newborn Rabbit: An Autoradiographic Study of Changes during Development

Tuor

1991

Pediatr Res

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“…The birth weights shown in Table 1 for newborn preterm rabbits of different gestational ages are similar to those reported by others for preterm rabbits of comparable ages (12,14). Average body weights were related directly to gestational age (Table 1) but inversely to litter size (Table 2).…”

Section: Resultssupporting

confidence: 83%

The Preterm Rabbit: A Model for the Study of Acute and Chronic Effects of Premature Birth

Lorenzo

1985

Pediatr Res

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“…Variations in neurocapsular growth patterns and timing have also been observed in rabbits and humans. Approximately 90% of brain growth in rabbits is completed by 35 days of age (Harel et al, 1972;Kier, 1976;Alberius and Selvik, 1985;Masoud et al, 1986;Cooper et al, 1999), as compared to about 4 -6 years of age in humans (Enlow and McNamara, 1973;Kier, 1976;Enlow, 1990). Thus, in humans a much greater length of time would be needed for sutural exposure to Tgf-␤3 to prevent premature suture fusion.…”

Section: Discussionmentioning

confidence: 99%

“…Longitudinal body weight and coronal suture growth data were obtained from all rabbits at 10, 25, 42, and 84 days of age (at this age, approximately 80 -90% of calvarial and brain growth is completed in the rabbit) (Harel et al, 1972;Masoud et al, 1986;Mooney et al, 1994b;Burrows et al, 1995).…”

Section: Data Collectionmentioning

confidence: 99%

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

et al. 2003

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Craniosynostosis results in cranial deformities and increased intracranial pressure, which pose extensive and recurrent surgical management problems. Developmental studies in rodents have shown that low levels of transforming growth factor-␤3 (Tgf-␤3) are associated with normal fusion of the interfrontal (IF) suture, and that Tgf-␤3 prevents IF suture fusion in a dose-dependent fashion. The present study was designed to test the hypothesis that Tgf-␤3 can also prevent or "rescue" fusing sutures in a rabbit model with familial craniosynostosis. One hundred coronal sutures from 50 rabbits with delayed-onset, coronal suture synostosis were examined in the present study. The rabbits were divided into five groups of 10 rabbits each: 1) sham controls, 2) bovine serum albumin (BSA, 500 ng) low-dose protein controls, 3) low-dose Tgf-␤3 (500 ng), 4) high-dose BSA (1,000 ng) controls, and 5) high-dose Tgf-␤3 (1,000 ng). At 10 days of age, radiopaque amalgam markers were implanted in all of the rabbits on either side of the coronal suture to monitor sutural growth. At 25 days of age, the BSA or Tgf-␤3 was combined with a slow-absorbing collagen vehicle and injected subperiosteally above the coronal suture. Radiographic results revealed that high-dose Tgf-␤3 rabbits had significantly greater (P Ͻ 0.05) coronal suture marker separation than the other groups. Histomorphometric analysis revealed that high-dose Tgf-␤3 rabbits also had patent coronal sutures and significantly (P Ͻ 0.01) greater sutural widths and areas than the other groups. The results suggest that there is a dose-dependent effect of TGF-␤3 on suture morphology and area in these rabbits, and that the manipulation of such growth factors may have clinical applications in the treatment of craniosynostosis. Anat Rec Part A 274A: 962-971, 2003.

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Growth and Development of the Rabbit Brain

Cited by 126 publications

References 22 publications

Local Cerebral Blood Flow in the Newborn Rabbit: An Autoradiographic Study of Changes during Development

Local Cerebral Blood Flow in the Newborn Rabbit: An Autoradiographic Study of Changes during Development

The Preterm Rabbit: A Model for the Study of Acute and Chronic Effects of Premature Birth

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

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