Growth and differentiation of osteoblastic cells on 13–93 bioactive glass fibers and scaffolds

Bioactive glass and glass-ceramic scaffolds for bone tissue engineering

“…In addition to providing excellent in vitro bioactivity [14,43,94,109,110,115], cell biology behavior [15,105,114,118,119] and favorable mechanical properties [99,102,105], bioactive glassceramic scaffolds have shown superior in vivo behavior (e.g., bone formation, mineralization, higher interfacial strength between implant and bone) compared to the glass in particulate form [113] or compared to other bioactive materials (HA, tricalcium phosphate) [52].…”

Laser Spinning of Bioactive Glass Nanofibers

“…Two main different techniques were initially employed to produce the glass fibers: spraying [6,7] or dry-spinning [7,8] of a solgel precursor or by directly melting the glass and forming it through a platinum bushing. [9][10][11][12][13][14] Typical diameters of these fibers range from one micron up to several tens of microns. All of these works concluded that these kinds of scaffolds have the potential to direct and mediate cell growth as tissue engineering constructs in bone regeneration with different degrees of bioactivity depending on the composition, microstructure and surface features.…”

“…For this reason, less fragile compositions with higher silica content were used, which can be fiberized and which can be tailored to provide controlled degradation but are still less bioactive than the 45S% glass. [9][10][11][12][13] Alternatively, the techniques based on a sol-gel precursor offer a higher flexibility to vary composition but they produce fibers with lower strength [15] and rely on the utilization of chemical solvents. On the other hand, the laser spinning technique has been demonstrated to produce fibers from a wide range of compositions, including non-fiberizing fragile melts, with no chemical additives involved in the process.…”

Development and Applications of Varieties of Bioactive Glass Compositions in Dental Surgery, Third Generation Tissue Engineering, Orthopaedic Surgery and as Drug Delivery System

“…In addition, pore distribution, interconnectivity and size are of paramount significance in order to assurance of proper cell proliferation and migration, as well as tissue vascularization and diffusion of nutrients. The concept of using bioactive glass substrates as templates for in vitro synthesis of bone tissue for transplantation by assessing the osteogenic potential has been investigated (Xynos et al, 2000;Phan et al, 2003;Chen et al, 2008;Brown et al, 2008) and confirmed that Bioglass scaffolds have potential as osteoconductive tissue engineering substrates for maintenance and normal functioning of bone tissue ). Human primary osteoblast-like cells cultured in contact with different bioactive glass suggested that bioglass not only induces osteogenic differentiation of human primary osteoblast-like cells, but can also increase collagen synthesis and release.…”

“…As summarized in Table 2 [reproduced from (Gerhardt & Boccaccini, 2010)], most of the studies have mainly investigated the mechanical properties, in vitro and cell biological behavior of glass-ceramic scaffolds (Baino et al, 2009;Boccaccini et al, 2007;Bretcanu et al, 2008;Brown et al, 2008;Chen et al, 2007;Chen et al, 2006a;Chen et al, 2008a;Chen et al, 2006b;Deb et al, 2010;Fu et al, 2010;Fu et al, 2007;Fu et al, 2008;Ghosh et al, 2008;Haimi et al, 2009;Klein et al, 2009;Kohlhauser et al, 2009;Mahmood et al, 2001;Mantsos et al, 2009;Miguel et al, 2010;Ochoa et al, 2009;Renghini et al, 2009;Vargas et al, 2009;Vitale-Brovarone et al, 2009a;Vitale-Brovarone et al, 2010;Vitale-Brovarone et al, 2009b;Vitale-Brovarone et al, 2008;Vitale-Brovarone et al, 2004;Vitale-Brovarone et al, 2005;Vitale-Brovarone et al, 2007;Vitale Brovarone et al, 2006). Scaffolds with compressive strength (Baino et al, 2009;Fu et al, 2010) and elastic modulus values (Fu et al, 2010;Fu et al, 2008) in magnitudes far above that of cancellous bone and close to the lower limit of cortical bone have been realized.…”