Growth arrest specific protein 7 inhibits tau fibrillogenesis

Shimizu, Tori; Hirose, Keiko; Uchida, Chiyoko; Uchida, Takafumi

doi:10.1016/j.bbrc.2020.03.041

Cited by 6 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The accumulation of hyperphosphorylated tau has been heavily implicated in AD's pathogenesis. The protein encoded by the switch gene GAS7 that we identified inhibits the production of phosphorylated tau by binding to its C-terminal domain and preventing conversion into fibrils and blocking aggregation, thus potentially playing a neuroprotective role in AD [33]. Both low and high levels of GAS7 in neurons have been implicated in the pathogenesis of AD progression.…”

Section: Genesmentioning

confidence: 99%

Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex

Bottero

Powers

Yalamanchi

et al. 2021

IJMS

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a chronic, neurodegenerative brain disorder affecting millions of Americans that is expected to increase in incidence with the expanding aging population. Symptomatic AD patients show cognitive decline and often develop neuropsychiatric symptoms due to the accumulation of insoluble proteins that produce plaques and tangles seen in the brain at autopsy. Unexpectedly, some clinically normal individuals also show AD pathology in the brain at autopsy (asymptomatic AD, AsymAD). In this study, SWItchMiner software was used to identify key switch genes in the brain’s entorhinal cortex that lead to the development of AD or disease resilience. Seventy-two switch genes were identified that are differentially expressed in AD patients compared to healthy controls. These genes are involved in inflammation, platelet activation, and phospholipase D and estrogen signaling. Peroxisome proliferator-activated receptor γ (PPARG), zinc-finger transcription factor (YY1), sterol regulatory element-binding transcription factor 2 (SREBF2), and early growth response 1 (EGR1) were identified as transcription factors that potentially regulate switch genes in AD. Comparing AD patients to AsymAD individuals revealed 51 switch genes; PPARG as a potential regulator of these genes, and platelet activation and phospholipase D as critical signaling pathways. Chemical–protein interaction analysis revealed that valproic acid is a therapeutic agent that could prevent AD from progressing.

show abstract

Section: Genesmentioning

confidence: 99%

Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex

Bottero

Powers

Yalamanchi

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“… 60 Our analysis results showed that GAS7 was significantly elevated in the peripheral blood of AD patients, which was controversy to the data in the brain. 58 - 60 We speculate that this may be the result of feedback regulation. Peripheral GAS7 may be used as a marker of hyperphosphorylated Tau protein aggregation in the brain of AD patients.…”

Section: Discussionmentioning

confidence: 90%

“…Studies have found that GAS7 can interact with hyperphosphorylated Tau to prevent its aggregation, thus potentially playing a neuroprotective role in AD. 58 However, some studies also have found that high levels of GAS7 will interfere with kinesin, which may destroy the homeostasis of Tau in the central nervous system. 59 Therefore, GAS7 protein level has a very important regulatory role for the development of AD.…”

Section: Discussionmentioning

confidence: 99%

Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer’s Disease

Qiu¹,

Weng

2022

Am J Alzheimers Dis Other Demen

View full text Add to dashboard Cite

Background: We aimed to make an integrated analysis of published transcriptome and DNA methylation dataset to ascertain the key differentially methylated and differentially expressed genes for Alzherimer’s disease (AD). Methods: Two gene expression microarrays and 1 gene methylation microarray were downloaded for identification of differentially expressed genes and differentially methylated genes. Then, we used various biological information databases to annotate the functions of the differentially-methylated/expressed genes, and screen out key genes and important signaling pathways. Finally, we validate the differentially-methylated/expressed genes in the additional online datasets and in blood from AD patients.Results: A total of 8 hub hypomethylated-high expression genes were obtained, including Rac family small GTPase 2, FGR proto-oncogene, Src family tyrosine kinase, LYN proto-oncogene, Src family tyrosine kinase, protein kinase C delta, myosin IF, integrin subunit alpha 5, semaphorin 4D, and growth arrest specific protein 7. Some enriched signaling pathways of hypomethylated-high expression genes were identified, including regulation of actin cytoskeleton, chemokine signaling pathway, Fc gamma R-mediated phagocytosis, and axon guidance. Conclusion: Differentially-methylated/expressed genes are likely to be associated with AD.

show abstract

“…Studies point that neurodevelopmental proteins, in specific, fasciculation and elongation protein zeta-1 (Fez1), platelet-activating factor acetylhydrolase, isoform Ib, PAFAH1B1 or lissencephaly 1 protein (Lis1), nuclear distribution element-like (Nudel) interact with Disc1 [6, 17]. Similarly, WISH (WASP interacting SH3 protein), Neural-Wiskott Aldrich syndrome protein (N-WASP), tau protein interacts with Gas7 [18, 19], and assist in neuronal differentiation. The results from current co-immunolocalization indicate that Disc1 and Gas7 co-localize in a functionally relevant neuronal subtype in mice brain.…”

Section: Discussionmentioning

confidence: 99%

“…The co-immunoprecipitation data supports the result from co-immunolocalization where the co-immunoprecipitation of Disc1 and Gas7 were observed in the brain tissue lysate. Studies by Morris et al [6] and Shimizu et al [19] indicate that, Disc1 and Gas7 protein binding partners are specific to nervous system. Ju et al [8] and Schurov et al [13] points that Disc1 and Gas7 are associated with the neuronal development.…”

Section: Discussionmentioning

confidence: 99%

Co-immunolocalization of Disc1 and Gas7 protein in adult mice brain

Kumar

2022

Brain Science Advances

View full text Add to dashboard Cite

Objective: The aim of the present study was to check the potential interaction of two neurodevelopmental proteins, Disc1 and Gas7, in the adult mice brain. Methods: Twenty-four male Swiss albino mice were used for the study. The mice were 12 weeks old in the beginning of the experiment. Immunohistochemistry and co-immunofluorescence were performed on the coronal sections of mice brain and immunoblotting and co-immunoprecipitation were done on the whole brain lysate. Results: Data from immunohistochemistry and co-immunofluorescence indicate the occurrence and co-localization of Disc1 and Gas7 proteins in soma and projections of the brain cells. Immunostaining was observed in cerebral cortex, hypothalamus, midbrain, pons, medulla oblongata and CA3 of hippocampus of the brain. The data from Immunoblotting and co-immunoprecipitation validates the presence and interaction of Disc1 and Gas7 protein in whole brain lysate. Conclusion: Data indicates the potential interaction of Disc1 and Gas7 protein in adult brain. The study highlights the need for further research on Disc1–Gas7 protein interaction in brain development and neuro-disorders.

show abstract

Growth arrest specific protein 7 inhibits tau fibrillogenesis

Cited by 6 publications

References 23 publications

Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex

Key Disease Mechanisms Linked to Alzheimer’s Disease in the Entorhinal Cortex

Screening of Crucial Differentially-Methylated/Expressed Genes for Alzheimer’s Disease

Co-immunolocalization of Disc1 and Gas7 protein in adult mice brain

Contact Info

Product

Resources

About