Growth-associated protein-43 is elevated in the injured rat sciatic nerve after low power laser irradiation

Shin, Dong Hoon; Lee, Eun‐Ju; Hyun, Jung Keun; Lee, Seong Jae; Chang, Young Pyo; Kim, Jong Wan; Choi, Yong Seok; Kwon, Bum Sun

doi:10.1016/s0304-3940(03)00354-9

Cited by 66 publications

(50 citation statements)

References 17 publications

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“…Nos últimos anos, a comunidade científica tem se voltado para o estudo da ação do laser de baixa potência na regeneração nervosa periférica 13,[25][26][27][28][29] , tendo definido aspectos da metodologia de aplicação, como o melhor comprimento de onda, número de aplicações e período de irradiação 12 . Apesar dos vários estudos, a determinação do tratamento mais eficaz para recuperação de lesão nervosa ainda não está totalmente elucidada 25,32,33 . De acordo com Anders et al 34 , há grande variedade metodológica entre os estudos, desde o comprimento de onda do laser até os tipos de lesões provocadas, além dos parâmetros de avaliação.…”

Section: Discussionunclassified

“…A aplicação do laser em nervos também tem sido muito utilizada na prática clínica e descrita na literatura, sendo a laserterapia reconhecida como um adjuvante efetivo da regeneração nervosa 8,[25][26][27][28][29][30] . A recuperação da função e morfologia após lesão nervosa geralmente é incompleta e imperfeita, justificando o recurso terapêutico.…”

Section: Introductionunclassified

“…Assim, os resultados apresentados sugerem que o laser de baixa potência facilita a regeneração nervosa periférica após lesão de nervo periférico de ratos 9,17,25 , fundamentando a utilização do laser para acelerar processos cicatriciais, em estudos experimentais e na prática clínica 16 .…”

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Efeitos da aplicação do laser de baixa potência na regeneração do nervo isquiático de ratos

et al. 2010

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RESUMO: Os nervos periféricos sofrem constantes lesões de origem traumática, o que resulta em perdas funcionais. A terapia com laser de baixa potência vem sendo utilizada para minimizar os efeitos maléficos da inflamação e acelerar o processo de cicatrização dos tecidos lesados. Este estudo teve como objetivo verificar o efeito da irradiação do laser 830 nm no comportamento do nervo isquiático de ratos submetido a esmagamento. Foram utilizados 20 ratos, todos tendo tido o nervo isquiático esmagado, divididos em 4 grupos (n=5): P7 e P14, tratamento placebo por 7 e 14 dias; L7 e L14, tratamento por laser (dosagem de 4 J/cm²) por 7 e 14 dias. Os animais dos grupos P7 e P14 foram submetidos aos mesmos procedimentos, mas com o laser desligado. Os parâmetros analisados foram presença de infiltrado inflamatório e fibroblastos, destruição da bainha de mielina e degeneração axonal. Na análise estatística foi observada diferença estatística com relação a três parâmetros: os animais do grupo L14 apresentaram maior quantidade de fibroblastos (p=0,0001), menor degeneração da bainha de mielina (p=0,007) e menor quantidade de infiltrado inflamatório (p=0,001). A aplicação do laser de baixa potência contribuiu para a redução do processo inflamatório decorrente da lesão do nervo isquiático de ratos. DESCRITORES: Nervo ciático; Regeneração nervosa; Síndromes de compressão nervosa/reabilitação; Terapia a laser de baixa intensidade ABSTRACT: Peripheral nerves are commonly subject to traumatic injuries, leading to functional loss. Low-power laser therapy has been used in order to minimize harmful effects of inflammation and to accelerate healing of injured tissues. The purpose of this study was to assess the effect of 830 nm-laser irradiation on rat sciatic nerves submitted to crush. Twenty male Wistar rats had their sciatic nerve crushed and were divided into 4 groups (n=5): Sham7 and Sham14, placebo-treated for 7 and 14 days; L7 and L14, laser-treated (at 4 J/cm²) for 7 and 14 days. Sham group animals were submitted to the same procedures, but with the laser turned off. Assessed parameters were inflammatory infiltrates, fibroblasts, myelin sheath destruction, and axonal degeneration. The statistical analysis showed significant differences in three parameters: L14 animals showed more fibroblasts (p=0.0001), lesser myelin sheath degeneration (p=0.007), and lesser inflammatory infiltrates (p=0.001). Low-power laser therapy hence contributed to reduce the inflammatory process due to rat sciatic nerve injury.

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Section: Discussionunclassified

Section: Introductionunclassified

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Efeitos da aplicação do laser de baixa potência na regeneração do nervo isquiático de ratos

et al. 2010

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“…31,32 Early application of laser also favorably affects nerve regeneration. 33,34 Transcutaneous application of Ga-As laser (903 nm, 27 mW) 3 minutes daily for 1, 3, 5 and 7 weeks was found to improve the morphology and function of damaged sciatic nerve fibers in rats. 35 Increase in myelinated axons, decrease in degenerated axons and increase in nerve conduction velocity were significant in the irradiated group of rats as compared to the control group in the third and fifth weeks of treatment.…”

Section: Discussionmentioning

confidence: 98%

“…30 In both cases reported in this study, the treatment started during the first consultation, as studies have shown that early application favorably modulates inflammation 31,32 and nerve regeneration. 33 When laser irradiation was applied immediately after carrageenan-induced inflammation, the animals did not suffer from traumatic injury or vascular damage. 31,32 Early application of laser also favorably affects nerve regeneration.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Bell's Palsy Using Monochromatic Infrared Energy: A Report of 2 Cases

Chu

2014

Journal of Chiropractic Medicine

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Objective: The purpose of the study is to describe the use of monochromatic infrared energy (MIRE) therapy in the management of 2 patients with Bell's palsy. Clinical features: Two patients presented to a chiropractic clinic with Bell's palsy that was diagnosed by a medical physician. Both patients were treated using MIRE. The acute patient was a 32-year-old male. He presented with left facial palsy 1 day before the consultation. He was unable to puff the left cheek and close the left eyelid. He had difficulty raising the left eyebrow. The chronic case was a 46-year-old lady. Prior to the first consultation, she was treated with corticosteroid and electro-acupuncture for one and a half years, with incomplete recovery. When first seen, the left corner of mouth drooped and she had difficulty raising her left eyebrow. Intervention and outcome: Monochromatic infrared energy therapy, emitting 890 nm infrared light, was placed on the post-auricular area, pre-auricular area, the temple and mandibular area of the affected side. Each treatment lasted 30 minutes. Photographs were taken every week to document changes. The acute case received 19 treatments in 6 weeks. He reported an improvement of 95%. The chronic case received a total of 45 treatments in 9 months. She rated an improvement of 50%. At the conclusion of treatment, she was able to close her left eyelid and puff her left cheek but still could not raise her left eyebrow. Conclusion: These 2 patients seemed to respond to a different degree to the MIRE therapy. As 71% of patients with Bell's palsy recover uneventfully without any treatment, the present study describes the course of care but cannot confirm the effectiveness of MIRE therapy in the management of Bell's palsy.

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Nerve repair by light

Sperandio

Huang

Parizotto

et al. 2015

Lasers in Dentistry

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Growth-associated protein-43 is elevated in the injured rat sciatic nerve after low power laser irradiation

Cited by 66 publications

References 17 publications

Efeitos da aplicação do laser de baixa potência na regeneração do nervo isquiático de ratos

Efeitos da aplicação do laser de baixa potência na regeneração do nervo isquiático de ratos

Treatment of Bell's Palsy Using Monochromatic Infrared Energy: A Report of 2 Cases

Nerve repair by light

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