Growth factor loading on aliphatic polyester scaffolds

Shen, Hong; Hu, Xuhua

doi:10.1039/d0ra10232f

Cited by 21 publications

(12 citation statements)

References 95 publications

(138 reference statements)

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“…In the TE field, growth factors (GF) are a fundamental element since they have the potency to induce and enhance cellular responses [ 18 , 70 ]. According to Shen et al [ 20 ], tissue regeneration with only cells and scaffolds is often unsuccessful, and exogenous growth factors must be in place to initiate the regeneration process. In this context, PLLA-base scaffolds incorporating growth factors were proposed to improve their biological activity and induce cell differentiation [ 38 , 70 , 71 , 72 ].…”

Section: Plla As a Biomaterialsmentioning

confidence: 99%

“…Biochemical or physical processes can induce superficial modifications, thus influencing the hydrophobicity of the PLLA and improving cell adhesion and protein adsorption [ 18 , 19 ]. A similar response is achieved by introducing growth factors into the material, thus facilitating tissue repair both in vitro and in vivo [ 20 , 21 ]. Tissue engineering has undergone remarkable progress, developing scaffolds with ideal properties using composite or hybrid systems.…”

Section: Introductionmentioning

confidence: 99%

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Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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Synthetic biopolymers are effective cues to replace damaged tissue in the tissue engineering (TE) field, both for in vitro and in vivo application. Among them, poly-l-lactic acid (PLLA) has been highlighted as a biomaterial with tunable mechanical properties and biodegradability that allows for the fabrication of porous scaffolds with different micro/nanostructures via various approaches. In this review, we discuss the structure of PLLA, its main properties, and the most recent advances in overcoming its hydrophobic, synthetic nature, which limits biological signaling and protein absorption. With this aim, PLLA-based scaffolds can be exposed to surface modification or combined with other biomaterials, such as natural or synthetic polymers and bioceramics. Further, various fabrication technologies, such as phase separation, electrospinning, and 3D printing, of PLLA-based scaffolds are scrutinized along with the in vitro and in vivo applications employed in various tissue repair strategies. Overall, this review focuses on the properties and applications of PLLA in the TE field, finally affording an insight into future directions and challenges to address an effective improvement of scaffold properties.

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Section: Plla As a Biomaterialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

et al. 2022

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“…4 In addition to providing physical support for cells, TE scaffolds must also act as a substrate for cell proliferation, migration, differentiation, and secretion of extracellular matrix (ECM). 5 Hence, scaffolds must be biocompatible and must exhibit a porous microstructure to provide support for cell performance. 6 Ideally, biopolymeric scaffolds should be constructed in a manner that mimics the complex architecture of native tissues.…”

Section: Introductionmentioning

confidence: 99%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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“…Therefore, by using appropriate growth factors in scaffolds, the process of bone tissue regeneration can be improved [12]. Growth factors are biologically active factors in the organs and tissues of the body that are responsible for regulating and transmitting vital signals between cells and their environment and subsequently providing osteogenic properties in tissue regeneration [13,14]. PRP is an excellent mixture of essential growth factors in platelet granules, based on their release, which manages a cascade of neovascogenesis and tissue regeneration processes.…”

Section: Introductionmentioning

confidence: 99%

Osteogenesis Capability of Gelatin-based biomimetic Scaffold containing PRP-loaded Starch Nanoparticles

Boraei

Nourmohammadi

Shokrollahi

et al. 2023

Preprint

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A new generation of scaffolds capable of acting not only as support for cells but also as a source of biological cues to promote tissue regeneration is currently a hot topic in bone Tissue Engineering (TE) research. The controlled release of the Growth Factors (GFs) from the scaffolds is a suitable strategy to achieve such a goal. Platelet Rich Plasma (PRP) is an autologous source of GFs, providing several bioactive agents known to act on bone regeneration. In this study, citric acid-modified starch nanoparticles loaded with PRP will be included in a gelatin scaffold. Scaffolds were evaluated in vitro with respect to compressive strength, water uptake, and protein release. The size of the pores in the production scaffolds was evaluated to be around 150 microns which is suitable for bone regeneration. The scaffolds were then seeded with human adipose-derived stem cells (hASCs) and cultured in vitro. The osteogenic behavior of the seeded hASCs was evaluated by alkaline phosphatase activity (ALP activity) and calcium assay analysis. The results show the promotion of morphological, mechanical, and biological properties of the scaffolds by adding PRP-loaded nanoparticles. Our results suggest that the PRP-loaded starch nanoparticles enhance the biological and bone regeneration of the gelatin-based scaffolds.

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Growth factor loading on aliphatic polyester scaffolds

Abstract: Cells, scaffolds and growth factors are three elements of tissue engineering. Growth factors precisely controlled by a scaffold will be used in conjunction with the scaffolds and cells to repair and regenerate defect tissue.

Cited by 21 publications

References 95 publications

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

Poly-l-Lactic Acid (PLLA)-Based Biomaterials for Regenerative Medicine: A Review on Processing and Applications

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Osteogenesis Capability of Gelatin-based biomimetic Scaffold containing PRP-loaded Starch Nanoparticles

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