Growth factors and beta-tricalcium phosphate in the treatment of periodontal intraosseous defects: A systematic review and meta-analysis of randomised controlled trials

Călin, Claudiu; Pătrașcu, Ion

doi:10.1016/j.archoralbio.2016.02.007

Cited by 19 publications

(17 citation statements)

References 34 publications

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“…Although two careful reviews had been published about the clinical efficacy of rhPDGF-BB and rhFGF-2 on periodontal healing, both of them suffered from some important weaknesses 37, 38 . Among the problems were: a limited number of RCTs, questionable or inconsistent inclusion and exclusion criteria, failure to distinguish among the growth factors as to their differential potential in periodontal repair, and failure to take into account the possible dose-dependent factors affecting their impact.…”

Section: Discussionmentioning

confidence: 99%

“…The criteria for inclusion should also be improved. We encountered inconsistencies in the inclusion criteria utilized by Khoshkam 2015 38 and Claudiu 2016 37, 38 . The meta-analysis of Khoshkam 38 combined data from patients who had been treated with rhFGF-2 groups and those who had been treated with rhPDGF-BB 38 .…”

Section: Discussionmentioning

confidence: 99%

“…In this light, two earlier meta-analyses had already focused on the effect of growth factors on periodontal repair 37, 38 . Unfortunately, each of these studies suffered from limitations that weakened their clinical value (The problems will be identified and discussed below).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Recombinant Human FGF-2 and PDGF-BB in Periodontal Regeneration: A Systematic Review and Meta-Analysis

et al. 2017

Sci Rep

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The prognosis for successful treatment of periodontal diseases is generally poor. Current therapeutic strategies often fail to regenerate infected periodontium. Recently an alternative strategy has been developed that combines conventional treatment with the application of recombinant human growth factors (rhGFs). But ambiguities in existed studies on the clinical efficacy of rhGFs do not permit either the identification of the specific growth factors effective for therapeutic interventions or the optimal concentration of them. Neither is it known whether the same rhGF can stimulate regeneration of both soft tissue and bone, or whether different patient populations call for differential use of the growth factors. In order to explore these issues, a meta-analysis was carried out. Particular attention was given to the therapeutic impact of fibroblast growth factor 2(FGF-2) and platelet derived growth factor BB (PDGF-BB). Our findings indicate that 0.3% rhFGF-2 and 0.3 mg/ml rhPDGF-BB show a greater capacity for periodontal regeneration than other concentrations and superiority to control groups with statistical significance. In the case of patients suffering only from gingival recession, however, the application of rhPDGF-BB produces no significant regenerative advantage. The findings of this study can potentially endow clinicians with guidelines for the appropriate application of these two rhGFs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluation of Recombinant Human FGF-2 and PDGF-BB in Periodontal Regeneration: A Systematic Review and Meta-Analysis

et al. 2017

Sci Rep

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“…32 Effects of TCP can be exaggerated with strategic addition of growth factors in vivo , as was seen throughout a series of randomized control trials using platelet-derived growth factor and β-TCP as agents to heal periodontal intraosseous defects. 33 In fact, β-TCP has been shown to contribute to bone healing faster than hydroxyapatite alone, secondary to its rapid rate of resorption. 34 Meanwhile, HAPEX is an amalgamation of the biologic mineral hydroxyapatite and synthetic high-weight polyethylene.…”

Section: Grafts Based On Bone Mineral Componentsmentioning

confidence: 99%

Biomimetics of Bone Implants: The Regenerative Road

Brett

Flacco

Blackshear

et al. 2017

BioResearch Open Access

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The current strategies for healing bone defects are numerous and varied. At the core of each bone healing therapy is a biomimetic mechanism, which works to enhance bone growth. These range from porous scaffolds, bone mineral usage, collagen, and glycosaminoglycan substitutes to transplanted cell populations. Bone defects face a range of difficulty in their healing, given the composite of dense outer compact bone and blood-rich inner trabecular bone. As such, the tissue possesses a number of inherent characteristics, which may be clinically harnessed as promoters of bone healing. These include mechanical characteristics, mineral composition, native collagen content, and cellular fraction of bone. This review charts multiple biomimetic strategies to help heal bony defects in large and small osseous injury sites, with a special focus on cell transplantation.

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“…In addition, β-TCP could be functionalized by various organic compounds, such as sodium lauryl sulfate [297], fumaric acid [298] and some other compounds [299,319,320]. Functionalization of β-TCP served two major roles: first, it provided a barrier that prevented premature β-TCP-fluoride interactions, and second, it provided a targeted delivery of β-TCP when applied to the teeth.…”

Section: Dcpd and Dcpamentioning

confidence: 99%