Growth factors for angiogenesis in peripheral arterial disease

Gorenoi, Vitali; Brehm, Michael; Koch, Armin; Hagen, Anja

doi:10.1002/14651858.cd011741.pub2

Cited by 31 publications

(23 citation statements)

References 73 publications

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“…Local interventions reducing wound pain included one study each on ibuprofen‐containing wound dressings, or a growth factor construct or two studies applying topical anaesthetic cream before ulcer debridement …”

Section: Resultsmentioning

confidence: 99%

“…Most (14 controlled studies on 389 patients) reported healing outcomes for those with severe PAD. Systematic reviews have reported that three RCTs each supported faster or earlier complete healing of ischaemic ulcers on patients with ABI > 0.5 managed with autologous stem cell therapy or angiogenic growth factors . Two studies each supported improved ulcer healing in patients with severe PAD receiving lower leg IPC or spinal cord stimulation .…”

Section: Resultsmentioning

confidence: 99%

“…This appraisal of the literature evaluated the frequency of significantly improved patient‐centred outcomes in research characterised by non‐standardised varying outcome measures. Evidence quality, assessed elsewhere, was often very low due to heterogeneity of data, lack of blinding, and small study sample size . The extent of PAD involvement in ulcer development was unclear for MLU, so ulcer healing results stratified to moderate severity in Figure may have included subjects with severe PAD.…”

Section: Discussionmentioning

confidence: 99%

“…The authors reviewed 221 abstracts and/or full‐text studies qualifying for inclusion and summarised evidence, supporting significant improvements reported for each patient‐centred outcome measured in response to one or more interventions studied. Study quality and risk of bias, graded elsewhere, were not addressed in this work, which aimed to describe the frequency of studies improving patient‐centred outcomes, not evaluating evidence strength or quality. Probability of type I error of ≤.05 was the criterion for a statistically significant effect of an intervention on a patient‐centred outcome.…”

Section: Methodsmentioning

confidence: 99%

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Peripheral arterial disease: Scoping review of patient‐centred outcomes

Bolton

2019

International Wound Journal

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Peripheral arterial disease (PAD) impairs patients' quality of life (QOL), walking and ulcer healing, increasing patient pain, costs, and risks of amputation or mortality. A literature appraisal described PAD treatment capacity to improve validated patient-centred outcomes in controlled clinical studies. The PUBMED database was searched from 1 January 1970 to 21 June 2018, for original and derivative controlled clinical trial references addressing MeSH terms for 'ischemia' AND 'leg ulcer'. Non-ischemic ulcer treatment references were excluded. Frequencies of improved (P < .05) outcomes were reported. Eighty-eight studies on 4153 patients were summarized. Walking, pain or QOL improved mainly for interventions administered before PAD became severe. Amputation incidence, pain and ulcer healing were more frequently reported in those with severe PAD. Independent of PAD severity, patients experienced more likely improved walking, QOL, or pain reduction in response to structured walking interventions or those increasing calf muscle activity. Those with more severe PAD were more likely to report amputation reduction, mainly in response to invasive interventions. Those with PAD experienced more consistently improved patient-centred outcomes if they received multidisciplinary PAD management with supervised walking or calf muscle activity, with more likely amputation risk reduced for those with more severe PAD. Key Messages• Peripheral arterial disease (PAD) progresses in severity from impaired walking and quality of life (QOL) through increasing likelihood of pain, ulceration, gangrene, amputation, or death and magnifies clinical, economic, and patient burdens of venous insufficiency or diabetes • improving PAD-related patient-centred outcomes requires consistent early, effective PAD diagnosis and effective treatment to improve lower limb perfusionAbbreviations: ABI, ankle-to-brachial systolic blood pressure index (ratio), optimally performed using handheld Doppler ultrasound; ALU, arterial leg ulcers; CLI, critical limb ischaemia; DAPT, dual antiplatelet therapy, for example, aspirin plus low molecular weight heparin; DFU, diabetic foot ulcers; ER, endovascular revascularisation; HBO, hyperbaric oxygen; IC, intermittent claudication; IPC, intermittent pneumatic compression of the calf muscle; MLU, mixed aetiology leg ulcers complicated with peripheral arterial disease; NMES, neuromuscular electrical stimulation sufficient to cause contraction of the calf muscle; PAD, peripheral arterial disease; PPG, photoplethysmography a technique for measuring venous emptying; QOL, quality of life; RCT, randomised clinical trial; SET, structured exercise therapy supervised by a professional; SOC, standard of care; TcPO 2 , transcutaneous partial pressure of oxygen; VLU, venous leg ulcer.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Peripheral arterial disease: Scoping review of patient‐centred outcomes

Bolton

2019

International Wound Journal

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“…Polymer nanoparticles such as poly(lactic‐ co ‐glycolic acid) nanoparticles (PLGA NPs) have also been used for targeted delivery of therapeutic agents, including genes to ischemic sites in peripheral arteries to overcome safety issues of viral vectors for gene delivery . The VEGF cDNA loaded NPs promoted significant angiogenesis with dense capillaries, improved collateral circulation, and improved expression of the VEGF gene in rabbit ischemic models when compared to that of naked plasmid administration .…”

Section: Application Of Nanoparticles For the Treatment Of Padmentioning

confidence: 99%

Nanoparticles for Detection and Treatment of Peripheral Arterial Disease

Noukeu

Wolf

Yuan

et al. 2018

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Peripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower extremity arterial vessels characterized by chronic narrowing that often results in occlusion and is associated with loss of functional capacity. Although the PAD occurrence rate is increasing in the elderly population, outcomes with current treatment strategies are suboptimal. Hence, there is an urgent need to develop new technologies that overcome limitations of traditional modalities for PAD detection and therapy. In this Review, the application of nanotechnology as a tool that bridges the gap in PAD diagnosis and therapy is in focus. Several materials including synthetic, natural, biodegradable, and biocompatible materials are used to develop nanoparticles for PAD diagnostic and/or therapeutic applications. Moreover, various recent research approaches are being explored to diagnose PAD through multimodality imaging with different nanoplatforms. Further efforts include targeted delivery of various therapeutic agents using nanostructures as carriers to treat PAD. Last, but not least, despite being a fairly new field, researchers are exploring the use of nanotheranostics for PAD detection and therapy.

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