“…Nanoparticles (NPs) offer potential benefits in biomedicine due to their unique chemical and physical properties (Tran and Webster, 2010;Thanh, 2012;Giner-Casares et al, 2016;Cardoso et al, 2018;He et al, 2018;Wagner et al, 2019). As a result, they are used in many biological and biomedical applications including drug delivery (Bonini et al, 2013;Toy and Roy, 2016;El-Boubbou, 2018;Liyanage et al, 2019;Xu et al, 2020), heat-assisted treatments, and medical imaging (Huang et al, 2011;Dutz and Hergt, 2014;Blanco-Andujar et al, 2016;Noukeu et al, 2018;Fratila et al, 2019;Paris et al, 2020). The efficiency of these applications is strongly dependent on the interaction of NPs with cells and tissues, and it is affected by several particle properties including their shape, size, composition, and surface functionalization (Decuzzi et al, 2010;Petros and DeSimone, 2010;Verma and Stellacci, 2010;Bartczak et al, 2012; Barua and Mitragotri, 2014;Jiang et al, 2016).…”