Growth Factors for Neuronal Survival and Process Regeneration

Lipton, Stuart A.

doi:10.1001/archneur.1989.00520470113038

Cited by 23 publications

(7 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Defined media also contain several hormones, including insulin, triiodothyronine, corticosterone, progesterone, angiotensin-11, and vasopressin (Iwasaki et al, 1991;Romijn et al, 19881, that would be present in crude serum. There are in addition several tissue-derived growth factors with specific trophic actions on cultured neurons (Hughes et al, 1993;Lipton, 1989;Reynolds and Weiss, 1992). These substances are not components of blood, but their trophic actions may be enhanced by the inclusion of serum in the culture medium (Juurlink et al, 1991).…”

Section: Possible Harmful Effects Of Plasma Proteinsmentioning

confidence: 99%

Vascular permeability in the peripheral autonomic and somatic nervous systems: Controversial aspects and comparisons with the blood-brain barrier

Kiernan

1996

Microsc. Res. Tech.

View full text Add to dashboard Cite

Endothelium, choroidal epithelium, and arachnoid exclude plasma proteins from most parts of the mammalian central nervous system (CNS). Nerve roots, in contrast, have permeable capillaries and permeable pia‐arachnoid sheaths. Diffusion of plasma proteins into the cerebrospinal fluid is probably prevented by slow bulk flow along a pressure gradient from the subarachnoid space into the veins of the roots. In nerves, the perineurium prevents diffusion of proteins from the epineurium into the endoneurium. Capillaries within fascicles are permeable to macromolecules, though less so than the microvessels of roots and ganglia. Endoneurial vascular permeability is lowest in rats and mice, but even in these species albumin is normally present in the extracellular spaces around the nerve fibers. The so‐called blood‐nerve barrier is not equivalent to the blood‐brain barrier. Capillaries in sensory and sympathetic ganglia are fully permeable to macromolecules, and extravasated protein is in contact with neuronal cell bodies and neurites. An impenetrable perineurium surrounds each ganglion, but serves no obvious purpose when the vessels inside are as permeable as those outside. The enteric nervous system lacks a perineurium, and the neurons in its avascular ganglia and tracts are exposed to extracellular fluid formed by permeable vessels in adjacent tissues of the gut. The reasons for excluding macromolecules from some parts of the nervous system are obscure. Carrier‐mediated transport, which maintains a constant supply of ions, glucose, and other metabolites to cells in the CNS, would be impossible if larger molecules could diffuse freely. Presumably the metabolic needs of ganglia are adequately met by exchange vessels similar to those of nonnervous tissues. Most of the CNS is protected from exogenous toxic substances that bind to plasma proteins. Peripheral neurons and glial cells are damaged by some such substances because of the lack of blood‐tissue barriers. © 1996 Wiley‐Liss, Inc.

show abstract

Section: Possible Harmful Effects Of Plasma Proteinsmentioning

confidence: 99%

Vascular permeability in the peripheral autonomic and somatic nervous systems: Controversial aspects and comparisons with the blood-brain barrier

Kiernan

1996

Microsc. Res. Tech.

View full text Add to dashboard Cite

show abstract

“…Neurotrophic factors are signaling proteins that enhance neuronal survival, maintenance, and differentiation, but they also can increase neurite growth and neurotransmitter production. 188 Developed on the basis of extensive analysis of NGF, criteria to define neurotrophic factors as "targetderived" factors have been proposed (Table 1). 23 However, as much remains to be learned about neurotrophic factors, these criteria are, at best, tentative.…”

mentioning

confidence: 99%

Neurotrophic factors and neuro-muscular disease: II. GDNF, other neurotrophic factors, and future directions

Mitsumoto

Tsuzaka

1999

Muscle Nerve

View full text Add to dashboard Cite

“…Várias são as substâncias potencializadoras da regeneração neural e, muitas delas, já usadas em testes clínicos (Levi-Montalcini et al, 1953;Stelmack et al, 1977;Strand et al, 1980;Levi-Montalcini, 1982;Sparrow et al 1982;Hurst et al, 1984;Leeden, 1984;Danielsen et al, 1986;Edwards et al, 1986;Lipton et al, 1986;Badalamente et al, 1987;Bansberg et al, 1987;Mengs et al, 1987;Kaupilla et al, 1988;Zinder, 1988;Badalamente et al, 1989;Chen et al, 1989;Cuello et al, 1989;Kujawa et al, 1989;Klein et al, 1989;Lipton, 1989;Snider et al, 1989;Santos et al, 1991;Lainetti et al, 1993;Costa et al, 1997;Costa et al, 2006).…”

Section: Os Animais Dosunclassified

“…Dentre os fármacos mais conhecidos podemos citar: poliaminas e aminoguanidinas (Kaupilla et al, 1988;Gilad et al, 1996), ativadores da adenil-ciclase (Klein et al, 1989;Urbina et al, 1996;Walikonis et al, 1998), fator de crescimento neural (Levi-Montalcini et al, 1953;Levi-Montalcini,1982;Lipton, 1989;Snider et al, 1989;Chen et al, 1989;Santos et al, 1991;Jubran et al, 2003), triancinolonas (Lipton et al, 1986;Bansberg et al, 1987) , alfa-MSH (Edwards et al, 1986), ACTH (Strand et al, 1980), leupeptina (Hurst et al, 1984;Badalamente et al, 1987;Badalamente et al, 1989;), apoliproteínas (Badalamente et al, 1987), T3 (Stelmack et al, 1977), T4 (Danielsen et al, 1986), testosterona (Kujawa et al, 1989, gangliosídeos (Sparrow et al. 1982;Leeden, 1984;Mengs et al, 1987;Cuello et al, 1989;Laineti et al, 1993) e imunossupressores (Gold, 1997;Costa e al., 2006 (Ferreira et al, 1974;Ehrart et al, 1975;Ferreira et al, 1975;Zumiotti et al, 1988;Mattar et al, 1990;Costa, 1998;Costa, 2001 (Ferreira et al, 1985), de paralisias dos membros superiores e inferiores (Ferreira et al, 1974;…”

unclassified

Reconstrução de defeito de nervo fibular em ratos com veia glicerolada: análise histológica e funcional

Cunha¹

View full text Add to dashboard Cite

pela amizade desde meus dias de faculdade, residência e pós-graduação. Aos meus irmãos, Regina e Sílvio, pelo apoio, amor, amizade e convívio durante toda a minha vida. A João Fábio e Brigite, pelo carinho e por estarem sempre presentes em minha vida no convívio familiar. À minha sogra D. Otacília Vidal, pelo exemplo de humildade e perseverança. A Agner, Jéfferson, Luciana, Roberta, Rodolfo e Marlon, pelo convívio, auxílio, amizade e bons momentos de confraternização. À Marília e Rômulo Terra, pela amizade e apoio em todas situações. À Daniela Renata Crippa pela amizade e convívio nestes últimos anos. Ao Prof. Ciro Ferreira Da-Silva, pelo ensino e incentivo e determinação desde o terceiro ano da faculdade. Por ser um exemplo de pesquisador e professor, tornando-se participante e pessoa fundamental para a realização desta pesquisa. Ao meu colega e amigo Dr. Roberto Albuquerque Ribeiro, que aprendi a admirar e confiar. Agradeço seus conselhos, apoio e incentivo. Ao Dr. Paulo Tuma Jr., pelo exemplo de ética profissional, pelo convívio e conselhos em minha formação de cirurgião plástico. Ao Dr. José Carlos Marques de Faria, que sempre tive como exemplo de cirurgião plástico. Ao Dr. Edgard Cardenas pelo convívio dos últimos anos e sua amizade. Ao Dr. Amir Salomão Gebrin, pela amizade e convívio. Pelas pesquisas realizadas anteriormente que foram base de nosso conhecimento. Aos assistentes da Disciplina de Cirurgia Plástica da Faculdade de Medicina da Universidade de São Paulo, pelos momentos compartilhados e pelos ensinamentos, importantes na minha formação de cirurgião plástico. À Eliane Gazetto da Pós-Graduação da Clínica Cirúrgica pelo auxílio durante o período da pós-graduação. Ao Sr. Fábio Tadeu Montesano, pela realização da estatística deste trabalho através da empresa Domus Numeri. Ao Sr. Márcio Xavier Nascimento, pelas figuras e desenhos deste trabalho através da empresa 3 em 1 Design. À Sra. Fernanda Rizzo Sanchez, pela revisão desta tese. EPÍGRAFE o homem que adquire ente (Provérbios 3:13) Esta tese está de acordo com as seguintes normas, em vigor no momento desta publicação: Referências: adaptado de International Committee

show abstract

Growth Factors for Neuronal Survival and Process Regeneration

Cited by 23 publications

References 97 publications

Vascular permeability in the peripheral autonomic and somatic nervous systems: Controversial aspects and comparisons with the blood-brain barrier

Vascular permeability in the peripheral autonomic and somatic nervous systems: Controversial aspects and comparisons with the blood-brain barrier

Neurotrophic factors and neuro-muscular disease: II. GDNF, other neurotrophic factors, and future directions

Reconstrução de defeito de nervo fibular em ratos com veia glicerolada: análise histológica e funcional

Contact Info

Product

Resources

About