Growth, Growth Velocity and Adult Height in Mexican Girls with Turner's Syndrome

Abstract

This was a prospective, longitudinal and descriptive study of 117 Mexican girls with Turner's syndrome (TS) followed from diagnosis to 18 years old. Height, weight and growth velocity were evaluated every 4-6 months, and bone age was assessed annually. Adult height was reached in 87 girls. All the girls were treated during 1 year with conjugated estrogens at bone age of 12 years, and subsequently with mixed estrogen/progestogen. Growth retardation in girls with TS is apparent at birth (2.7 +/- 0.9 kg and 46.3 +/- 5.0 cm) and in childhood, but becomes most marked when puberty would normally occur. Mean growth velocity was less than 25th percentile from birth to 2 years, less than 10th percentile between 3-9 years, and less than 3rd percentile from 10 to 18 years of age. Final adult height was 136.9 +/- 5.5 cm, but it is affected by the particular karyotype: 46,Xi(Xq): 134.5 cm, 45,XO: 137.3 cm, and 45XO/46,XX: 139 cm.

Composição e proporções corporais em pacientes com sindrome de turner com e sem tratamento com hormonio de crescimento em relação a um grupo de mulheres normais

“…Tabela 1-Altura final de pacientes com ST de acordo com a população estudada. Por essas razões, o acompanhamento do crescimento na ST deve ser verificado em curvas específicas para essa população, criadas a partir dos dados das médias e desvios-padrão de altura de meninas com ST em diferentes idades (ROSENBERG e TELL, 1972;LENKO et al, 1979;PELZ et al, 1982;RANKE et al, 1983).…”