Growth Hormone and Ghrelin Secretion in Severely Obese Women Before and After Bariatric Surgery

Mora, Maria Elena Valera; Manco, Melania; Capristo, Esmeralda; Iaconelli, Amerigo; Gniuli, Donatella; Rosa, G. De; Calvani, Menotti; Mingrone, Geltrude

doi:10.1038/oby.2007.240

Cited by 18 publications

(5 citation statements)

References 31 publications

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“…This finding supports the hypothesis that although the primary source of ghrelin is the gastric mucosa, small intestinal nutrient exposure is sufficient for food-induced plasma ghrelin suppression in humans and gastric nutrient exposure is not necessary for this suppression [42]. However, different studies have shown an increase [43–46] or no change [36, 41, 47] in ghrelin levels after BPD.…”

Section: Ghrelin and Biliopancreatic Diversionsupporting

confidence: 82%

Ghrelin and Metabolic Surgery

Pournaras

Roux

2010

International Journal of Peptides

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Section: Ghrelin and Biliopancreatic Diversionsupporting

confidence: 82%

Ghrelin and Metabolic Surgery

Pournaras

Roux

2010

International Journal of Peptides

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“…However, a number of researchers have found no significant change in ghrelin levels following gastric bypass 31,35,41,57 and BPD, 50,58 and higher ghrelin concentrations have also been reported following both RYGB 4,48–50 and BPD. 25,59,60 …”

Section: Search/inclusion Criteria For Studies Of Gut Hormones Followmentioning

confidence: 99%

Changes in neurohormonal gut peptides following bariatric surgery

et al. 2010

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The rising prevalence of obesity has reached pandemic proportions, with an associated cost estimated at up to 7% of health expenditures worldwide. Bariatric surgery is currently the only effective long-term treatment for obesity and obesity-related co-morbidities in clinically severely obese patients. However, the precise physiological mechanisms underlying the postsurgical reductions in caloric intake and body weight are poorly comprehended. It has been suggested that changes in hormones involved in hunger, food intake and satiety via the neurohormonal network may contribute to the efficacy of bariatric procedures. In this review, we consider how gastrointestinal hormone concentrations, involved in appetite and body weight regulation via the gut–brain axis, are altered by different bariatric procedures. Special emphasis is placed on neurohormonal changes following Roux-en-Y gastric bypass surgery, which is the most common and effective procedure used today.

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“…A post-surgical reduction of ghrelin may contribute to the persistent weight loss reported in obese patients following gastric bypass and mixed malabsorptive procedures. However, a number of studies demonstrated no significant change in ghrelin levels following gastric bypass [97,107] and BPD [108], or even higher ghrelin concentrations following both RYGB [109–111] and BPD [112–114]. …”

Section: Interactions Between Gut Peptides and Brain Systems Relevmentioning

confidence: 99%

The neurohormonal regulation of energy intake in relation to bariatric surgery for obesity

Ochner

Gibson

Carnell

et al. 2010

Physiology & Behavior

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Obesity has reached pandemic proportions, with bariatric surgery representing the only currently available treatment demonstrating long-term effectiveness. Over 200,000 bariatric procedures are performed each year in the US alone. Given the reliable and singular success of bariatric procedures, increased attention is being paid to identifying the accompanying neurohormonal changes that may contribute to the resulting decrease in energy intake. Numerous investigations of postsurgical changes in gut peptides have been conducted, suggesting greater alterations in endocrine function in combination restrictive and malabsorptive procedures (e.g., Roux-en-Y gastric bypass) as compared to purely restrictive procedures (e.g., gastric banding), which may contribute to the increased effectiveness of combination procedures. However, very few studies have been performed and relatively little is known about changes in neural activation that may result from bariatric procedures, which likely interact with changes in gut peptides to influence postsurgical caloric intake. This review provides a background in the neurohormonal regulation of energy intake and discusses how differing forms of bariatric surgery may affect the neurohormonal network, with emphasis on Roux-en-Y gastric bypass, the most commonly performed procedure worldwide. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.

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Growth Hormone and Ghrelin Secretion in Severely Obese Women Before and After Bariatric Surgery

Cited by 18 publications

References 31 publications

Ghrelin and Metabolic Surgery

Ghrelin and Metabolic Surgery

Changes in neurohormonal gut peptides following bariatric surgery

The neurohormonal regulation of energy intake in relation to bariatric surgery for obesity

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