Growth hormone and the risk of atherosclerosis in growth hormone-deficient children

Binay, Çiğdem; Şimşek, Enver; Yıldırım, Atilla; Köşger, Pelin; Demiral, Meliha; Kılıç, Zübeyir

doi:10.1016/j.ghir.2015.08.005

Cited by 15 publications

(13 citation statements)

References 37 publications

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“…Childhood exposure to O3 may be a novel risk factor for CIMT in a healthy population of college students [ 143 ]. Additionally, higher CIMT was associated with the development of chronic kidney disease [ 144 ], growth hormone deficiency [ 145 ], beta-thalassemia minor [ 146 ], preeclampsia [ 142 ] and menopause transition [ 147 ]. However, recent studies could not show associations of elevated parathyroid hormone (PTH) concentrations [ 136 ] and normal-tension glaucoma [ 48 ] with altered CIMT.…”

Section: The Associations Between Cimt and Novel Risk Factorsmentioning

confidence: 99%

Causes of changes in carotid intima-media thickness: a literature review

2015

Cardiovasc Ultrasound

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Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) predicts future cardiovascular and ischaemic stroke incidence. CIMT, a measure of atherosclerotic disease, can be reliably determined in vivo by carotid ultrasound. In this review, we determined that CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking, alcohol consumption, habitual endurance exercise, blood pressure, dyslipidemia, dietary patterns, risk-lowering drug therapy, glycemia, hyperuricemia, obesity-related anthropometric parameters, obesity and obesity-related diseases. We also found that CIMT is associated with novel risk factors, including heredity, certain genotypic indices, anthropometric cardiovascular parameters, rheumatoid arthritis, immunological diseases, inflammatory cytokines, lipid peroxidation, anthropometric hemocyte parameters, infectious diseases, vitamin D, matrix metalloproteinases, and other novel factors and diseases. However, the conclusions are inconsonant; the underlying causes of these associations remain to be further explored.

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Section: The Associations Between Cimt and Novel Risk Factorsmentioning

confidence: 99%

Causes of changes in carotid intima-media thickness: a literature review

2015

Cardiovasc Ultrasound

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“…The CAVI data are presented as mean±SD (standard deviation). that sleep induces growth hormone release, which, in turn, protects against atherosclerosis and carotid intima-media thickness in children 32) . Therefore, long sleep may reduce CAVI in children.…”

Section: Resultsmentioning

confidence: 97%

Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults

Masumitsu

Kubozono

Miyata

et al. 2022

JAT

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Aim: This study aims to investigate the association of the Cardio-Ankle Vascular Index (CAVI) with self-reported sleep duration and sleep quality in community-dwelling older adults aged ≥ 65 years. Methods:The Tarumizu Study was a cohort of community-based health checkups conducted in the Tarumizu City, Japan, in 2018 and 2019. In total, 997 participants aged ≥ 65 years (median age, 74 years) were examined. We obtained the average sleep duration and sleep quality using self-reported questionnaires and classified them into three separate groups according to sleep duration (＜6 h, 6-8 h, and ≥ 8 h) and sleep quality (good, medium, and poor). The arterial stiffness was measured using the CAVI.Results: As per our findings, the CAVI was significantly higher in the ≥ 8 h sleep group (CAVI=9.6±1.3) than in the ＜6 h (CAVI=9.1±1.1) or 6-8 h (CAVI=9.1±1.2) groups (p＜0.001). After adjustment for age, sex, systolic blood pressure, current smoking status, body mass index, frequency of exercise, educational background, frailty, sleep medication, sleep quality, and nap duration, multivariable regression analysis demonstrated that the CAVI was significantly higher in the ≥ 8 h group than in the 6-8 h group (p=0.016). In contrast, multivariable regression analysis showed that there was no significant association between sleep quality and CAVI.Conclusions: A significant association was noted between long sleep duration (≥ 8 h) and elevated CAVI in community-dwelling older adults aged ≥ 65 years. We, therefore, suggest that long sleep duration, not sleep quality, is correlated with arterial stiffness in older adults.

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“…Un aumento de las cifras de triglicéridos y disminución de las LDL tras un año de tratamiento fue notificado por Witkouska-Sedek et al 34 Algunos estudios no encontraron cambios significativos en el perfil lipídico después de 12 meses de tratamiento. 6,17,36,46 La mayoría de los estudios 8,18,28,37,47,43 al comparar los niños con DGH con niños sanos señalan un perfil lipídico desfavorable en los primeros. En algunas investigaciones 17,36 no se detectan diferencias.…”

Section: Discussionunclassified

Alteraciones metabólicas en niños con deficiencia de hormona de crecimiento

Martínez¹,

Ramos²,

Alonso

2021

cysa

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El déficit de hormona del crecimiento (DGH) en la infancia se asocia a factores que aceleran la aterosclerosis. Objetivo: describir las alteraciones metabólicas en niños con deficiencia de hormona de crecimiento. Método: se realizó un estudio observacional, descriptivo y transversal que incluyó 53 pacientes con DGH a los cuales se les realizó un interrogatorio, examen físico y los estudios complementarios: prueba de tolerancia a la glucosa oral (PTG-O), lipidograma e insulinemia en ayunas. Resultados: predominó la hipertrigliceridemia en el sexo femenino, mientras las elevaciones de las LDL fueron más frecuentes en los menores de 5 años. Los valores de tensión arterial (TA), circunferencia de la cintura (CC) y el índice de masa corporal (IMC) se incrementan significativamente con la edad. Conclusiones: en los niños predominaron las alteraciones corporales, mientras que en las niñas fueron las alteraciones del lipidograma.

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Growth hormone and the risk of atherosclerosis in growth hormone-deficient children

Cited by 15 publications

References 37 publications

Causes of changes in carotid intima-media thickness: a literature review

Causes of changes in carotid intima-media thickness: a literature review

Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults

Alteraciones metabólicas en niños con deficiencia de hormona de crecimiento

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