Growth hormone (GH) treatment acts on the endocrine and autocrine/paracrine GH/IGF-axis and on TNF-α expression in bony fish pituitary and immune organs

Shved, Natallia; Berishvili, Giorgi; Mazel, Peter; Baroiller, Jean‐François; Eppler, Elisabeth

doi:10.1016/j.fsi.2011.08.012

Cited by 36 publications

(27 citation statements)

References 92 publications

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“…Following similar patterns reported in rainbow trout, coho salmon, common carp ( Cyprinus carpio), channel catfish, gilthead sea bream and Japanese eel ( Anguilla japonica ) (Shamblott et al, 1995; Tse et al, 2002; Vong et al, 2003; Carnevali et al, 2005; Petersen et al, 2005; Moriyama et al, 2008; Pierce et al, 2010), animals in this study showed markedly elevated hepatic igf2 expression following Gh treatment (Fig. 4E), similar to responses in intact animals (Eppler et al, 2010; Pierce et al, 2011; Shved et al, 2011). While multiple lines of evidence support the operation of Igf1, as opposed to Igf2, as the primary somatomedin in post-embryonic mammals (Le Roith et al, 2001), in light of the demonstrated bioactivity of native recombinant Igf2 to stimulate growth in tilapia (Chen et al, 2000) our data linking Gh with igf2 in hypophysectomized animals suggest that Igf2 should be further investigated as a possible somatomedin in tilapia.…”

Section: Discussionsupporting

confidence: 85%

Nutritional status and growth hormone regulate insulin-like growth factor binding protein (igfbp) transcripts in Mozambique tilapia

Breves

Tipsmark

Stough

et al. 2014

General and Comparative Endocrinology

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Growth in teleosts is controlled in large part by the activities of the growth hormone (Gh)/insulin-like growth factor (Igf) system. In this study, we initially identified igf-binding protein (bp)1b, -2b, -4, -5a and -6b transcripts in a tilapia EST library. In Mozambique tilapia (Oreochromis mossambicus), tissue expression profiling of igfbps revealed that igfbp1b and -2b had the highest levels of expression in liver while igfbp4, -5a and -6b were expressed at comparable levels in most other tissues. We compared changes in hepatic igfbp1b, -2b and -5a expression during catabolic conditions (28 days of fasting) along with key components of the Gh/Igf system, including plasma Gh and Igf1 and hepatic gh receptor (ghr2), igf1 and igf2 expression. In parallel with elevated plasma Gh and decreased Igf1 levels, we found that hepatic igfbp1b increased substantially in fasted animals. We then tested whether systemic Gh could direct the expression of igfbps in liver. A single intraperitoneal injection of ovine Gh into hypophysectomized tilapia specifically stimulated liver igfbp2b expression along with plasma Igf1 and hepatic ghr2 levels. Our collective data suggest that hepatic endocrine signaling during fasting may involve post-translational regulation of plasma Igf1 via a shift towards the expression of igfbp1b. Thus, Igfbp1b may operate as a molecular switch to restrict Igf1 signaling in tilapia; furthermore, we provide new details regarding isoform-specific regulation of igfbp expression by Gh.

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Section: Discussionsupporting

confidence: 85%

Nutritional status and growth hormone regulate insulin-like growth factor binding protein (igfbp) transcripts in Mozambique tilapia

Breves

Tipsmark

Stough

et al. 2014

General and Comparative Endocrinology

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“…The current results showed that there is a concordant relation between growth, igf1 and ghrs expression levels after 4 week treatment with exogenous Gh. Similar results were observed in other Gh‐treated fishes (Biga et al ., 2004; Gahr et al ., ; Biga & Meyer, ; Shved et al ., ). Interestingly, after the first 2 weeks of r‐pjGh administration, O .…”

Section: Discussionmentioning

confidence: 97%

“…On the other hand, few studies have analysed hepatic ghr transcription levels under Gh administration. Furthermore, conflicting results have been reported in ghr mRNA levels under Gh treatment (Gahr et al, 2008;Shved et al, 2011;Breves et al, 2014) possibly due to the presence of truncated Ghr (Ghrt) variants that result in opposite physiological effects (Fuentes et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Growth hormone receptors in the atherinid Odontesthes bonariensis: characterization and expression profile after fasting–refeeding and growth hormone administration

Botta

Simo

Sciara

et al. 2016

Journal of Fish Biology

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In order to improve the understanding of pejerrey Odontesthes bonariensis, growth hormone (Gh)-insulin-like growth factor-1(Igf1) axis, O. bonariensis growth hormone receptor type 1 (ghr1) and type 2 (ghr2) mRNA sequences were obtained. Both transcripts were ubiquitously expressed except in kidney, encephalon and anterior intestine. Alternative transcripts of both receptors were found in muscle. Interestingly, two different ghr2 transcripts with alternative polyadenylation (APA) sites located in the long 3' untranslated region (UTR-APA) were also found in liver. Hepatic ghr1, ghr2 and insulin-like growth factor type 1 (igf1) transcript levels were examined under two different metabolic conditions. In the first experimental condition, fish were fasted for 2 weeks and then re-fed for another 2 weeks. Despite igf1 mRNA relative expression did not show significant differences under the experimental period of time examined, both ghr transcripts decreased their expression levels after the fasting period and returned to their control levels after re-feeding. In the second treatment, recombinant O. bonariensis growth hormone (r-pjGh) was orally administered once a week. After 4 weeks of treatment, liver igf1, ghr1 and ghr2 mRNA relative expression increased (13, 4·5 and 2·1 fold, P < 0·05) compared to control values. These results add novel information to the growth hormone-insulin-like growth factor system in teleosts.

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“…Therefore, it was interesting to study the effect of GM-CSF on experimentally induced hypothyroidism in rat neonates through assessment of THs, TSH, GH, IGF, TNF-α and cerebellar oxidative stress & AchE activity. THs, TSH and IGF, GH, TNFα and AchE activity were found to be vital in the development [41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of GM-CSF in experimental neonatal hypothyroidism

Ahmed

Abdel‐Latif

Ahmed

2015

International Immunopharmacology

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Growth hormone (GH) treatment acts on the endocrine and autocrine/paracrine GH/IGF-axis and on TNF-α expression in bony fish pituitary and immune organs

Cited by 36 publications

References 92 publications

Nutritional status and growth hormone regulate insulin-like growth factor binding protein (igfbp) transcripts in Mozambique tilapia

Nutritional status and growth hormone regulate insulin-like growth factor binding protein (igfbp) transcripts in Mozambique tilapia

Growth hormone receptors in the atherinid Odontesthes bonariensis: characterization and expression profile after fasting–refeeding and growth hormone administration

Protective effects of GM-CSF in experimental neonatal hypothyroidism

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