Growth Hormone, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 Are Regulated Differently in Small-for-Gestational-Age and Appropriate-for-Gestational-Age Neonates

Cance-Rouzaud, A.; Laborie, Sophie; Bieth, Éric; Tricoire, J; Rolland, M; Grandjean, Hélène; Rochiccioli, P; Tauber, M T

doi:10.1159/000013996

Cited by 43 publications

(26 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study of normal children found that lower birth weight and IGF1 concentrations were associated with poor compensatory insulin secretion, suggesting a link between early somatotropic axis regulation and later metabolic derangement; these effects were independent of postnatal growth (22). Growth-restricted infants are also reported to have perturbed somatotropic axis regulation in the postnatal period independent of current nutritional status and have a higher rate of later metabolic disease (23). LBW followed by rapid growth in childhood is associated with the worst health outcomes in later life (24), including glucose intolerance, cardiovascular disease, and obesity (25,26).…”

Section: Discussionmentioning

confidence: 99%

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

et al. 2011

View full text Add to dashboard Cite

Periconceptional undernutrition and twin conception alter intrauterine growth and metabolism and are associated with later adverse metabolic outcomes. The contribution of postnatal growth to these outcomes is less well defined. We investigated whether maternal periconceptional undernutrition or twin conception altered postnatal growth regulation in ways that could lead to metabolic disease. Single and twin offspring of ewes undernourished (UN) from 61 d before until 30 d after mating, fed to achieve and maintain 10 -15% weight loss (UN), were compared with offspring of maintenance-fed controls (N). At 2 h and 1, 6, and 12 wk after birth, lambs were weighed and plasma hormone and metabolite concentrations analyzed. Milk intake, measured by deuterium oxide dilution, was inversely related to birth weight only in N singles, although twins had the greatest postnatal growth velocity. Positive associations were seen between milk intake, growth velocity, and leptin concentrations in N, but not UN, offspring. We conclude that periconceptional undernutrition alters the relationships between regulators of postnatal growth, including nutrient intake and key hormonal axes, in both singles and twins without affecting size at birth or postnatal growth velocity. Dissociation of growth from its key regulators is one possible mechanism underlying adverse metabolic outcomes after periconceptional undernutrition. (Pediatr Res 70: 261-266, 2011)

show abstract

Section: Discussionmentioning

confidence: 99%

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Fasting stimulates GH release in humans and infants with IUGR who characteristically show elevated basal levels of GH (Leger et al 1996, Cance-Rouzaud et al 1998. It has been unclear, however, what factors specifically activate this system in undernutrition.…”

Section: Discussionmentioning

confidence: 99%

Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers

Önal¹,

Cınaz²,

Atalay³

et al. 2004

Journal of Endocrinology

View full text Add to dashboard Cite

Ghrelin is a newly discovered orexigenic peptide originating from the stomach. Circulating ghrelin levels reflect acute and chronic energy balance in humans. However, it is not known whether ghrelin also plays a role in energy homeostasis during fetal life. Forty-one small-forgestational age (SGA) and 34 appropriate-for-gestational age (AGA) infants were studied in order to determine whether cord blood ghrelin concentrations were different in SGA infants compared with AGA infants and the relationship to anthropometric measurements at delivery. The cord blood ghrelin concentrations of SGA infants (means S.E.M.; 15·20 3·08 ng/ml) were significantly greater than of AGA infants (2·19 0·24 ng/ml) (P,0·0001). They were negatively correlated with the infants' birth weights (r= 0·481, P,0·0001) and with body mass index values (r= 0·363, P,0·001). The higher ghrelin concentrations were found in female infants (20·42 4·55 ng/ml) than in males (7·05 2·27 ng/ml) in the SGA group (P=0·042). These data provide the first evidence that cord ghrelin levels of SGA infants are greater than those of AGA infants and it is suggested that ghrelin is also affected by nutritional status in the intrauterine period.

show abstract

“…This finding was attributed to the state of undernutrition of these fetuses and a role for ghrelin in fetal adaptation to intrauterine malnutrition has been proposed (125,126). Furthermore, fasting is known to stimulate GH release in infants with IUGR, who characteristically show elevated basal levels of GH (127). Therefore, the augmented ghrelin concentrations in IUGR may consequently lead to elevated GH concentrations, as ghrelin has a potent GH-releasing activity (122).…”

Section: Ghrelin In Iugrmentioning

confidence: 99%

Intrauterine growth restriction and adult disease: the role of adipocytokines

Briana¹,

Malamitsi‐Puchner²

2009

European Journal of Endocrinology

126

View full text Add to dashboard Cite

Intrauterine growth restriction (IUGR) is the failure of the fetus to achieve his/her intrinsic growth potential, due to anatomical and/or functional disorders and diseases in the feto-placental-maternal unit. IUGR results in significant perinatal and long-term complications, including the development of insulin resistance/metabolic syndrome in adulthood.The thrifty phenotype hypothesis holds that intrauterine malnutrition leads to an adaptive response that alters the fetal metabolic and hormonal milieu designed for intrauterine survival. This fetal programming predisposes to an increased susceptibility for chronic diseases. Although the mechanisms controlling intrauterine growth are poorly understood, adipose tissue may play an important role in linking poor fetal growth to the subsequent development of adult diseases. Adipose tissue secretes a number of hormones, called adipocytokines, important in modulating metabolism and recently involved in intrauterine growth.This review aims to summarize reported findings concerning the role of adipocytokines (leptin, adiponectin, ghrelin, tumor necrosis factor (TNF), interleukin-6 (IL6), visfatin, resistin, apelin) in early life, while attempting to speculate mechanisms through which differential regulation of adipocytokines in IUGR may influence the risk for development of chronic diseases in later life.

show abstract

Growth Hormone, Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 Are Regulated Differently in Small-for-Gestational-Age and Appropriate-for-Gestational-Age Neonates

Cited by 43 publications

References 20 publications

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

Periconceptional Events Perturb Postnatal Growth Regulation in Sheep

Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers

Intrauterine growth restriction and adult disease: the role of adipocytokines

Contact Info

Product

Resources

About