Growth hormone receptor gene is related to root length and tooth length in human teeth

Yu, Hong‐Ren; Yamaguchi, Tetsutaro; Tomita, Daisuke; Abdelkéfi, Mohamed; Nakawaki, Takatoshi; Katayama, Kunihiro; Maki, Koutaro; Kimura, Ryosuke

doi:10.2319/092917-659.1

Cited by 13 publications

(11 citation statements)

References 42 publications

(48 reference statements)

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“…Some studies have reported that the length from the root to the top of the crown was about 20.7 mm and 21.1 mm in the maxillary and mandibular first molars respectively (Verhoeven et al 1979;Viecilli et al 2013;Hikita et al 2018). In our study, the maximum lengths were 20.6 mm and 21.4 mm in the maxillary and mandibular first molars respectively (Fig.…”

Section: Discussionsupporting

confidence: 57%

Estimation of three-dimensional long axes of the maxillary and mandibular first molars with regression analysis

et al. 2019

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The purpose of this study was to determine the long axes of molars with multiple roots through ordinary least squares regression (LSR) and to compare them with the axes defined by principal component analysis (PCA). Three-dimensional radiological images of 20 dry skulls were obtained by cone-beam computed tomography (CBCT). Data from maxillary and mandibular first molars were extracted from the CBCT DICOM data with a three-dimensional image visualization system. The obtained data were reconstructed, converted to STL files, and three-dimensional coordinate values were extracted. The long axes were estimated by an algorithm to synchronize the LSR line with the horizontal axis which was translated to the vertical axis. The axes of the molars defined by LSR were compared with the axes of the molars defined by PCA. The coordinate point number of each molar was 5400-5800. The algorithm for determining the tooth axes in this study consisted of four stages containing three steps each. The distance between the two axes calculated by the two methods (LSR and PCA) on the horizontal plane through the origin was less than 10 −12 mm and the deviations between them were less than 0.003°. The long axes of the molars estimated by LSR agree almost exactly with the axes estimated by PCA, and the accuracy is sufficient for clinical usage; however, the distance between them would shorten with a more severe convergence condition of the α value at each stage of this LSR system.

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Section: Discussionsupporting

confidence: 57%

Estimation of three-dimensional long axes of the maxillary and mandibular first molars with regression analysis

et al. 2019

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“…In this context, the association between variants of the GHR coding gene and craniofacial tissue phenotypes has been exhaustively addressed [ 4 ]. However, since 2013, new GHR variants, such as P561T, rs6184 SNP and rs6180, have been identified as associated, in one hand, with the face mandibular morphology and tooth dimensions [ 2 , 9 , 86 ] and, in the other hand, with developmental defects of enamel [ 12 ]. Recently Marañón-Vásquez et al showed that genetic polymorphisms in GHR (rs2973015) and IGF2R (rs2277071) have been associated with variations in craniofacial dimensions [ 87 ].…”

Section: Gh/igf Axis Modulates the Morphology Of The Dento-alveolar Complex And Cranio-facial Bonesmentioning

confidence: 99%

“…Among the various hormones and growth factors investigated, GH appears to be one of the most closely associated with dental maturity [ 8 ]. Recent studies have shown that GHR variants (rs6184 and rs6180) are associated with specific tooth and root dimensions [ 9 , 10 ], as well as with mandibular morphology [ 11 ]. Genetic polymorphisms in GHR (rs1509460) are also associated with developmental defects of enamel arguing for the GHR contribution to dental enamel synthesis and structure [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

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The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.

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“…This is in agreement with the results of the study by Hikita et al . [15] The authors found relationship of GHR variant rs6184 with RLs and tooth length for the upper and lower lateral incisors and upper canines.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Hikita et al . [15] found 46.6% and 8.1% allele frequencies of GHR variants for rs6180 and rs6184.…”

Section: Discussionmentioning

confidence: 99%

Assessment of correlation of growth hormone receptor gene with tooth dimensions: A CBCT and genotyping study

Shinde¹,

Mhaisekar²,

Chaube³

et al. 2019

J Pharm Bioall Sci

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Aim: Assessment of root morphology, size, and amount of bone around tooth is essential before starting the orthodontic treatment. The present study aimed to assess the relationship between tooth dimensions with two gene variants of growth hormone (GH), namely rs6184 and rs6180. Materials and Methods: This study was conducted on 218 subjects (males: 104, females: 114) requiring orthodontic treatment. All underwent cone beam computed tomography (CBCT) scan for orthodontic treatment planning with Kodak CBCT machine. In all teeth, crown height (CH), root length (RL), and crown–root ratio were evaluated. Two growth hormone receptor (GHR) variants (rs6184 and rs6180) were genotyped using the TaqMan genotyping assay. Results: The mean CH and RL of all teeth, that is, maxillary and mandibular central incisors, lateral incisor, canine, first premolar, second premolar, first molar, and second molar, were measured. There was no significant difference in males and females ( P > 0.05). Allele frequencies of GHR variants for rs6180 and rs6184 were 48.1% and 8.92%, respectively. Multiple regression analysis showed GHR rs6184 association with maxillary central incisor CH, maxillary canine RL, mandibular canine CH, and mandibular first premolar RL ( P < 0.05). Conclusion: There was correlation of CH of maxillary and mandibular canine and RL of maxillary canine and mandibular first premolar with GHR rs6184.

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Growth hormone receptor gene is related to root length and tooth length in human teeth

Abstract: The results indicate that the GHR rs6184 variant is associated with tooth length and ratio dimensions in a Japanese cohort. Further studies utilizing a larger sample size are needed to confirm this finding.

Cited by 13 publications

References 42 publications

Estimation of three-dimensional long axes of the maxillary and mandibular first molars with regression analysis

Estimation of three-dimensional long axes of the maxillary and mandibular first molars with regression analysis

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Assessment of correlation of growth hormone receptor gene with tooth dimensions: A CBCT and genotyping study

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