Growth hormone regulates the expression of UCP2 in myocytes

Futawaka, Kumi; Tagami, Tetsuya; Fukuda, Yuki; Koyama, Rie; Nushida, Ayaka; Nezu, Syoko; Imamoto, Miyuki; Kasahara, Masato; Moriyama, Kenji

doi:10.1016/j.ghir.2016.04.005

Cited by 10 publications

(4 citation statements)

References 33 publications

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“…The strong differences in the energy output of GH and Mel treated animals can be explained taking into account that GH increases the metabolism, improves the protein synthesis and the utilization of glucose, and decreases the lipid deposition [106–110]. Further, we saw that exogenous GH improves the motor performance in GH deficient individuals.…”

Section: Discussionmentioning

confidence: 91%

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats

Barceló

Nicolau

Gamundı́

et al. 2016

Oxidative Medicine and Cellular Longevity

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Growth hormone (GH) and melatonin are two hormones with quite different physiological effects. Curiously, their secretion shows parallel and severe age-related reductions. This has promoted many reports for studying the therapeutic supplementation of both hormones in an attempt to avoid or delay the physical, physiological, and psychological decay observed in aged humans and in experimental animals. Interestingly, the effects of the external administration of low doses of GH and of melatonin were surprisingly similar, as both hormones caused significant improvements in the functional capabilities of aged subjects. The present report aims at discerning the eventual difference between cognitive and motor effects of the two hormones when administered to young and aged Wistar rats. The effects were tested in the radial maze, a test highly sensitive to the age-related impairments in working memory and also in the rotarod test, for evaluating the motor coordination. The results showed that both hormones caused clear improvements in both tasks. However, while GH improved the cognitive capacity and, most importantly, the physical stamina, the effects of melatonin should be attributed to its antioxidant, anxiolytic, and neuroprotective properties.

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Section: Discussionmentioning

confidence: 91%

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats

Barceló

Nicolau

Gamundı́

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Moreover, the expression of the UCP2 mRNA is regulated by many factors in vivo, such as miRNAs 56 and growth hormones. 57 In addition, genetic polymorphisms in UCP2 have been reported, which may lead to changes in the structure/function/activity of gene products. 58 At the same time, SMYZD reversed the expression level of the aforementioned indexes.…”

Section: Discussionmentioning

confidence: 99%

ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway

Sun¹,

Liu²,

Liu³

et al. 2021

NDT

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Background ShenmaYizhi decoction (SMYZD) is an effective prescription of traditional Chinese medicine used to treat vascular dementia (VD). Modern research methods have identified its active ingredients clearly as gastrodin, ferulic acid, ginsenosides, and β-sitosterol. Chronic cerebral hypoperfusion is a driving factor or risk factor for VD, which leads to the disturbance of mitochondrial structure and function. Purpose To observe whether SMYZD improves cognitive impairment by improving mitochondrial structure and function. Methods Forty adult rats with vascular cognitive impairment (VCI) caused by the bilateral ligation of common carotid arteries were divided into four groups randomly, including the model group, donepezil group, and low-dose and high-dose SMYZD groups, with 10 rats in each group. Additionally, a sham group was established with 10 rats as the control group. The treatment groups were administered donepezil and two different dosages of SMYZD. The donepezil group was administered 0.45 mg/kg/d donepezil, and the SMYZ-L group was administered 2.97 g/kg/d SMYZ, which were equivalent to the clinical dosage. The SMYZ-H group was administered 11.88 g/kg/d SMYZ, which is 4 times higher than the clinically equivalent dosage. A sham-operated group was used as the control group and administered an equal volume of distilled water. The rats were treated by gavage for 8 consecutive weeks. Morris water maze (MWM) test was performed to evaluate the learning and memory ability. The mitochondria of brain tissue were extracted from brain for further test. Mitochondrial morphology and the signal path of AMPK/PPARα/PGC-1α/UCP2 in mitochondria were detected. Results With the SMYZD intervention, behavioral performance of rats and pathological changes of mitochondria of brain tissue were signiﬁcantly improved. In the serum, SOD, GSH-Px, and GSH activities were increased, and the MDA content was decreased. Moreover, the AMPK, PPARα, PGC-1α, UCP2, and ATP5A mRNA and protein expression levels were also reversed by SMYZD. Conclusion SMYZD may provide a potential therapeutic strategy via activating the AMPK/PPARα/PGC-1α/UCP2 signal pathway to improve mitochondrial structure and energy metabolism thereby alleviate vascular cognitive impairment.

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“…PPARG polymorphisms may be involved in the growth hormone/STAT5B pathway [35], and mice that were deficient in members of this pathway developed craniofacial abnormalities [30]. The growth hormone/STAT5B pathway also plays an important role in regulating energy metabolism in adipose and muscle tissue, suggesting that PPARG may cause craniofacial abnormalities and dysfunction of adipose and muscle tissue metabolism through this pathway [36,37]. In addition, the rs1801282 SNP is located in an exon and is a missense variant that affects the amino acid sequence of the PPARG protein (Pro12Ala).…”

Section: Discussionmentioning

confidence: 99%

Targeted sequencing analysis of PPARG identifies a risk variant associated with obstructive sleep apnea in Chinese Han subjects

Jiao

Yang

et al. 2019

Sleep Breath

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Purpose Obstructive sleep apnea (OSA) is a common disorder characterized by recurrent episodes of partial or complete upper airway obstruction. OSA susceptibility is associated with multiple genetic, environmental, and developmental factors. The PPARG rs1801282 (G/C) polymorphism has been associated with OSA in obese Indian subjects, whereas no such association has been reported in Chinese Han subjects. Potential associations between other PPARG variants and OSA have not been investigated in Chinese Han populations. The aim of this study was to identify genetic variants of PPARG in unrelated Chinese Han patients with OSA and to investigate potential associations between these variants and OSA. Methods We performed a cross-sectional study of 233 individuals with OSA and 93 control individuals. A portable diagnostic device was used to diagnose OSA. Targeted sequencing was conducted to identify PPARG variants. Associations between PPARG variants and OSA were analyzed using multivariate regression.Results Three PPARG single-nucleotide polymorphisms were identified and the genotype frequencies of the rs1801282 polymorphism differed significantly. Subjects with the PPARG rs1801282 CG genotype had decreased risk of having OSA compared with subjects with the CC genotype after adjusting for confounding effects. Conclusions We identified a variant of PPARG associated with the occurrence of OSA in Chinese Han populations.

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Growth hormone regulates the expression of UCP2 in myocytes

Cited by 10 publications

References 33 publications

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats

Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats

ShenmaYizhi Decoction Improves the Mitochondrial Structure in the Brain and Ameliorates Cognitive Impairment in VCI Rats via the AMPK/UCP2 Signaling Pathway

Targeted sequencing analysis of PPARG identifies a risk variant associated with obstructive sleep apnea in Chinese Han subjects

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