Growth hormone secretion in cachexia

Conte, F.A.; Kaplan, Selna L.; Abrams, Cyril A. L.; Grumbach, M.M.

doi:10.1016/s0022-3476(66)80556-5

The Journal of Pediatrics

1966

DOI: 10.1016/s0022-3476(66)80556-5

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Growth hormone secretion in cachexia

F.A. Conte¹,

Selna L. Kaplan²,

Cyril A. L. Abrams³

et al.

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1971

1983

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Cited by 4 publications

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“…(2) What are the fasting plasma GH levels in cases of chronic hydrocephalus? (3) What is the pos¬ sible role of the emaciation itself, or of semistarvation, on fasting plasma GH levels? (4) How is longitudinal growth affected by persistently ele¬ vated GH levels in the presence of chronic and progressive emaciation in the diencephalic syndrome?…”

mentioning

confidence: 99%

Growth Hormone in Marasmus Due to Cerebral Disease

Kerpel-Fronius¹,

Gács²,

Hervei³

1973

Arch Pediatr Adolesc Med

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In two cases of diencephalic syndrome with emaciation, very high fasting levels of plasma growth hormone (GH) were consistently found. Insulin injection and arginine hydrochloride stimulation did not always raise the hormone levels, and glucose loading resulted in incomplete suppression. Plasma insulin response to arginine stimulation and to glucose loading was blunted. Despite the presence of acromegalic levels of GH in the blood, longitudinal growth became as stunted as in other forms of malnutrition.To study the relative roles of cerebral damage and malnutrition, the same investigations were carried out in other groups of patients. High plasma GH levels were only found during manifest hypoglycemia or hypoproteinemia, and in one case of cerebral damage complicated by malnutrition and hypertonic dehydration. In 1951, Rüssel1 described a pe¬ culiar syndrome of intractable emaciation associated with initial growth acceleration, overactivity, and conspicuous pallor. In all five of his patients, a tumor was found in the diencephalic region. During the past 20 years, some 50 cases were recorded.

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mentioning

confidence: 99%

Growth Hormone in Marasmus Due to Cerebral Disease

Kerpel-Fronius¹,

Gács²,

Hervei³

1973

Arch Pediatr Adolesc Med

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“…Despite this overall evidence for an estrogen-induced prethrombotic state, Conte and Grumbach (1978) were unable to ascertain the actual occurrence of thromboembolic disease in almost 1000 tall girls treated with high doses of estrogens. The only convincing laboratory evidence for a prethrombotic state is deficiency of antithrombin III, and this has been claimed by Howie, Prentice and McNicol (1973) to be reduced by estrogens.…”

mentioning

confidence: 99%

High-Dose Conjugated Estrogens do not Reduce Antithrombin III Activity in Tall Girls

W¹,

Schmidt²

1983

Horm Metab Res

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Growth hormone in infant malnutrition: the arginine test in marasmus and kwashiorkor

et al. 1971

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I. Experiments in children and in animals seem to demonstrate that in marasmic malnutrition there is a reduction in the secretion of growth hormone. T o study this problem the fasting, resting plasma concentrations of growth hormone were determined, before, and 45 and 60 min after, stimulation with an intravenous dose of arginine, in six infants with marasmus, in six infants with kwashiorkor and in five normal infants. 2.The values of plasma growth hormone (4.1 k 0 . 9 7 ng/ml) in marasmic infants were significantly (P < o.001) lower than those of the controls (7.8 k 2.6 nglml), and responded little to stimulation with arginine (5.1 and 5.8 ng/ml at 45 and 60 min respectively), in contrast to those in the control group, which rose to 16.4 and 14.6 ng/ml. In children with kwashiorkor the values were very variable, but generally high, and showed little response (25.6 13.3 before and 25.0 f 17.6 and 14.2 f 5.3 ng/ml at 45 and 60 min after stimulation respectively).3. These results demonstrate that the responses of the hypophysis to deprivation of calories and protein (marasmus) and to protein deprivation (kwashiorkor) are different: in marasmus there is a progressive adaptation, with low secretion and poor reaction to stimulation, whereas in kwashiorkor the process is acute with high basal values of plasma growth hormone.

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Growth hormone secretion in cachexia

Cited by 4 publications

References 0 publications

Growth Hormone in Marasmus Due to Cerebral Disease

Growth Hormone in Marasmus Due to Cerebral Disease

High-Dose Conjugated Estrogens do not Reduce Antithrombin III Activity in Tall Girls

Growth hormone in infant malnutrition: the arginine test in marasmus and kwashiorkor

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