Growth Hormone, Skin and Wound Healing—experimental studies in the rat

Abstract

Cop y r i g h t0 A P M I S 199 7 &PMUS I S S N 0 9 0 3 -4 6 5 x I S B N 8 7-16-156 78-1 ACKNOWLEDGEMENTS This thesis is based on experimental works performed at the Department of Connective Tissue Biology, Institute of Anatomy, University of Aarhus, Denmark during my employment as a research fellow. It was a fascinating and most inspiring time and I wish to convey my heartiest thanks to all members of the staff at the institute.Some specific people, however must be mentioned here. Above all special thoughts go to my two friends Associate Professor Troels Torp Andreassen and Associate Professor Hans Oxlund, D.M.Sc.,who introduced me into the fields of collagen and wound healing. With enormous knowledge, patience and perseverance they were ready to discuss and give advice at any time of the day. And they were both able to look far beyond the limited walls of a scientific institute and consider the world in a broader sense. Dr. Bue Bak, D.M.Sc., withwhom I was lucky to share my office was an example to any scientist as he always sticked to the line in the search for his goals. Professor Hans Orskov, D.M.Sc., Hospital has been a great inspirator due to his enormous knowledge on growth hormone and engagement in any aspect of the exploration of this fascinating molecule.

Rat models of skin wound healing: A review

“…htm. The purpose of wound healing is to restore tissue continuity and resistance to externally applied forces 62 . In animal models, the progress of healing can be assessed by measuring the development of the mechanical strength of the wound 62 .…”

“…The purpose of wound healing is to restore tissue continuity and resistance to externally applied forces 62 . In animal models, the progress of healing can be assessed by measuring the development of the mechanical strength of the wound 62 . In the majority of the studies reviewed, evaluation of the skin models was accomplished by testing both the tensile and breaking strength of the wounded area with a tensiometer.…”

Effect of sildenafil citrate on secondary healing in full thickness skin defects in experiment

“…There are number of studies of electrostimulation and ultrasound therapy being benefi cial on secondary wound healing (22)(23)(24)(25)(26)(27)(28). Hydrotherapy, hyperbaric oxygen therapy, lasers, negative pressure therapy and a number of growth factors are reported to be useful in multiple studies.…”

Is growth hormone a radioprotective agent?

“…It has been reported that GH therapy in burn patients resulted in improved wound healing, delayed separation of eschars, increase in haemoglobin, serum albumin, calcium, phosphorus and glomerular filtration rate, and also a reduction in weight loss, nitrogen production rate, catabolic index, duration of sepsis and hospital stay 9 . A review clearly demonstrated that GH has advantageous effects on intact skin and wound healing 30 . To further assess this drug's potential radiation injury‐preventive effects, we studied the protective effect of GH in rats by using this radiation‐induced skin injury model.…”

“…9 A review clearly demonstrated that GH has advantageous effects on intact skin and wound healing. 30 To further assess this drug's potential radiation injury-preventive effects, we studied the protective effect of GH in rats by using this radiation-induced skin injury model.…”