Growth in infancy and bone mass in later life

Cooper, C; Egger, P.; Fall, C.H.D.; Eastell, Richard; Keen, R W; Spector, TD; Barker, Djp

doi:10.1016/8756-3282(95)97366-n

Cited by 66 publications

(100 citation statements)

References 12 publications

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“…A prenatal intake of 36% ethanolderived calories reduced fetal body weight in previous studies (10,11). Some studies found that low birth weight and deficient fetal bone development resulted in lower peak bone mass and an increased risk of future osteoporosis (33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Prenatal alcohol exposure reduces mandibular calcium and phosphorus concentrations in newborn rats

Carvalho

Martinelli

Milhan

et al. 2016

Journal of Oral Science

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Previous studies suggest that prenatal alcohol exposure affects fetal bone development, including bone quality. This study evaluated the chemical composition of mandibles from newborn rats after maternal 20% alcohol consumption before and throughout gestation. Nine rats were initially distributed into three groups: an Alcohol group, Pairfed group, and Control group. The groups were fed prespecified diets for 8 weeks before and the 3 weeks during pregnancy. At age 5 days, eight newborns from each group were euthanized (total, n = 24). Using energy dispersive spectrometry, we evaluated samples of mandibles from newborns to identify changes in bone mineralization, specifically Ca and P concentrations. Ca and P concentrations were lower in the Alcohol group than in the Control and Pair-fed groups (P = 0.003 and P = 0.001, respectively). In summary, alcohol exposure before and throughout gestation reduces mandibular Ca and P concentrations in newborn rats. (J Oral Sci 58, 439-444, 2016)

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Section: Discussionmentioning

confidence: 99%

Prenatal alcohol exposure reduces mandibular calcium and phosphorus concentrations in newborn rats

Carvalho

Martinelli

Milhan

et al. 2016

Journal of Oral Science

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“…With peak bone mass as a key stage in skeletal development prior to the onset of the natural process of age associated bone loss, determination of the relationship between birth weight and bone mass in early adulthood is imperative. Although numerous studies have been performed [18,19,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39], only a limited number involved women around the third decade and these generally employed small sample sizes. Hence the findings of our study enhances current knowledge and supports the idea of invoking preventive measures while parental awareness may be warranted for those with or at risk of lower birth weights.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of birth weight on bone mass at older ages (>60 years) is less clear [19], while studies in younger individuals indicate that birth weight effects are more pronounced for BMC than BMD [13,20].…”

Section: Introductionmentioning

confidence: 96%

Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women

2012

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Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women. Link to publication Citation for published version (APA): Callréus, M., McGuigan, F., & Åkesson, K. (2013). Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women. Osteoporosis International, 24(4), 1347 -1355 . DOI: 10.1007 /s00198-012-2077 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ABSTRACTPurpose: The aim of this study was to evaluate the influence of birth weight on peak bone mass and body composition in a cohort of 25-year-old women.Methods: 1061 women participated in this cross-sectional population-based study, using dual energy X-ray absorptiometry (DXA) to assess BMC, BMD and body composition (total body (TB), femoral neck (FN), total hip (TH), lumbar spine L1-L4 (LS), lean and fat mass). Birth weight data was available for 1047 women and was categorized into tertiles of low (≤3180 g 2.5kg total body lean mass). The strongest correlations between birth weight and BMC occurred in women with the lowest birth weights, although excluding women who weighed <2500 g at birth, the correlation remained significant although slightly weaker.Conclusions: Women with lower birth weight have lower bone mineral content, independent of current body weight, and less lean and fat mass at the age of 25. Lower birth weight has a greater negative influence on bone mass than the positive influence of higher birth weight.

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“…This results in permanent reduction in peak skeletal proportions attained later in life. Thus, several studies have shown that body weight in infancy is positively associated with adult bone mass (Cooper et al, 1997). Low rate of childhood growth has been associated with increased risk of hip fracture later in life .…”

Section: ) Consequences Of Alterations In Growth Hormone and Glucocomentioning

confidence: 99%

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

Liu

Xia

Guo

et al. 2012

J Expo Sci Environ Epidemiol

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The urinary metabolites of phthalates are well-accepted exposure biomarkers for adults and children older than 6 years but are not commonly used for infants owing to non-convenient sampling. In the light of this situation, a novel sampling method based on monitoring the urine expressed from the gel diaper was developed. The urine was expressed from the gel absorbent after mixing the absorbent with CaCl2 and then collected by a laboratory-made device; the urinary phthalate metabolites were extracted and cleaned using a solid-phase extraction (SPE) column and analyzed with high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry / mass spectrometry. To evaluate the method's feasibility, the following factors were investigated: the proportion of CaCl2 to gel absorbent, the urination volume variation and the target compounds' deposition bias in the diaper, the matrix blank of the different diaper brands, the storage stabilities and the recoveries of creatinine and phthalate metabolites in the expressed urine. Mono-methyl phthalate, mono-ethyl phthalate, mono-butyl phthalate, mono-benzyl phthalate, mono-2-ethylhexyl phthalate and mono-2-ethyl-5-oxohexyl phthalate were involved. 70-80% of the urine can be expressed from the diaper, and the expressed spiking recoveries and the limit of detection of mono-phthalates ranged from 88.5-115% and 0.21-0.50 ng/ml. The method was applied to measure phthalate metabolites in 65 gel diaper samples from 15 infants, and the pilot data suggests the infants are commonly exposed to phthalates. In summary, the method for monitoring of infant exposure to phthalates is sound and validated, and the potential health effects from the vulnerable infants' exposure to phthalates should be concerned.39th Scientific Research Foundation for the Returned Overseas Chinese Scholars (SRF for ROCS); Hundred Talent Program of Chinese Academy of Sciences (CAS); CAS/SAFEA International Partnership Program for Creative Research Teams [KZCX2-YW-T08

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Growth in infancy and bone mass in later life

Cited by 66 publications

References 12 publications

Prenatal alcohol exposure reduces mandibular calcium and phosphorus concentrations in newborn rats

Prenatal alcohol exposure reduces mandibular calcium and phosphorus concentrations in newborn rats

Birth weight is more important for peak bone mineral content than for bone density: the PEAK-25 study of 1,061 young adult women

Expressing urine from a gel disposable diaper for biomonitoring using phthalates as an example

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