Growth in utero and serum cholesterol concentrations in adult life.

Barker, David J.; Martyn, Christopher; Osmond, Clive; Hales, C. N.; Fall, C. H. D.

doi:10.1136/bmj.307.6918.1524

Cited by 561 publications

(384 citation statements)

References 27 publications

Supporting

Mentioning

344

Contrasting

Unclassified

Order By: Relevance

“…The current study has revealed that the LDL levels were raised at birth for neonates having smaller AC. These results are in agreement with reports made earlier [10]. The possible explanation of association between body disproportion at birth and LDL profile may be due to abnormal intrauterine growth.…”

Section: Discussionsupporting

confidence: 93%

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

2012

View full text Add to dashboard Cite

Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score [7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient. Results: Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates' lipid profile. Conclusion: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.

show abstract

Section: Discussionsupporting

confidence: 93%

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

2012

View full text Add to dashboard Cite

show abstract

“…We observed only one significant effect of declining growth velocity in the third trimester (IUGR), which was a raised total cholesterol: HDL-cholesterol ratio. A similar observation was made by Barker et al, who found raised total and LDL-cholesterol in association with low abdominal circumference at birth [24]. A disproportionate effect of growth restriction during the third trimester upon liver growth was proposed as the cause of this association.…”

Section: Discussionsupporting

confidence: 76%

The effect of birthweight upon insulin resistance and associated cardiovascular risk factors in adolescence is not explained by fetal growth velocity in the third trimester as measured by repeated ultrasound fetometry

et al. 2008

View full text Add to dashboard Cite

Aims/hypothesis Smallness for gestational age (SGA) is associated with increased risk of developing components of the metabolic syndrome. Although SGA can imply intrauterine growth restriction (IUGR), more information is required to link specific fetal growth patterns to adult outcomes. Methods We examined the impact of fetal growth velocity during the third trimester (FGV) vs birthweight for gestational age on early markers of the metabolic syndrome in 123 healthy men and women (mean age 17.5 years) born at term. FGV was determined by ultrasound measurements. Results After correction for confounders including current BMI, SGA was significantly associated with raised basal plasma insulin (+19% above appropriate for gestational age), homeostasis model assessment of insulin resistance (+21%), cholesterol:HDL-cholesterol ratio (+13%) and systolic BP (+4.8%) (all p<0.05). Furthermore SGA was associated with increased fat mass (+9.6%) and trunk-fat per cent (+6.8%) and with reduced lean body mass as determined by dual-energy X-ray absorptiometry scans (−4.1% below appropriate for gestational age) (all p<0.05). In contrast, IUGR in the third trimester was associated only with an elevated cholesterol:HDL-cholesterol ratio (+11% above not-IUGR). Conclusions/interpretation In the present study, FGV did not explain the impact of birthweight upon the metabolic phenotype in adolescence. This suggests that fetal growth prior to the third trimester or postnatal catch-up growth plays a more important role.

show abstract

“…Support for this comes from Hertfordshire were low weight at 1 year was associated with an atherogenic lipid profile in adult life. 25,26 Similar associations between infant growth and adult lipid profiles have been observed in the Helsinki Birth Cohort Study.…”

Section: Underlying Mechanismssupporting

confidence: 61%

Early growth, and coronary heart disease and type 2 diabetes: experiences from the Helsinki Birth Cohort Studies

Eriksson¹

2006

Int J Obes

View full text Add to dashboard Cite

Experiences during critical periods of development through the mechanisms of programming have consequences on later health outcomes. Observations worldwide linking a small body size at birth with adult health outcomes have greatly added to our understanding of the early origins of several non-communicable diseases like coronary heart disease (CHD) and type 2 diabetes. The pattern of growth predisposing to CHD is characterized by a small body size at birth and thinness through infancy up to 2 years of age, followed by accelerated gain in weight and body mass index (BMI) later in childhood. The early growth patterns of individuals who later develop type 2 diabetes very much resemble the growth patterns of CHD, that is, a small body size at birth and thinness at 1 year of age followed by higher body mass indices later in childhood. Numerous studies support the importance of events during critical periods of growth in the pathogenesis of many non-communicable diseases like CHD and type 2 diabetes. There are several possible mechanisms through which a non-optimal early growth associated with accelerated weight gain in childhood could lead to these diseases. To get a better understanding of the patterns of growth affecting adult health outcomes, a life-course approach to the development of chronic diseases needs to be taken.

show abstract

Growth in utero and serum cholesterol concentrations in adult life.

Cited by 561 publications

References 27 publications

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

The effect of birthweight upon insulin resistance and associated cardiovascular risk factors in adolescence is not explained by fetal growth velocity in the third trimester as measured by repeated ultrasound fetometry

Early growth, and coronary heart disease and type 2 diabetes: experiences from the Helsinki Birth Cohort Studies

Contact Info

Product

Resources

About