Growth Inhibition of Staphylococcus Aureus by Propofol/Lidocaine Admixture

Driver, Richard P.; Granus, Valerie; Yassa, Y.J.

doi:10.1097/00000539-199802001-00165

Cited by 7 publications

(1 citation statement)

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“…For P. aeruginosa , this reduction was more pronounced with reductions higher than 95% for LID concentrations of 0.5, 1, and 2 wt.%. These results emphasized the antimicrobial activity of LID [ 62 , 63 , 64 ], particularly against the most common bacteria found in infected wounds [ 10 ].…”

Section: Resultsmentioning

confidence: 88%

Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

et al. 2020

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The delivery of bioactive agents using active wound dressings for the management of pain and infections offers improved performances in the treatment of wound complications. In this work, solid lipid microparticles (SLMPs) loaded with lidocaine hydrochloride (LID) were processed and the formulation was evaluated regarding its ability to deliver the drug at the wound site and through the skin barrier. The SLMPs of glyceryl monostearate (GMS) were prepared with different LID contents (0, 1, 2, 4, and 10 wt.%) using the solvent-free and one-step PGSS (Particles from Gas-Saturated Solutions) technique. PGSS exploits the use of supercritical CO2 (scCO2) as a plasticizer for lipids and as pressurizing agent for the atomization of particles. The SLMPs were characterized in terms of shape, size, and morphology (SEM), physicochemical properties (ATR-IR, XRD), and drug content and release behavior. An in vitro test for the evaluation of the influence of the wound environment on the LID release rate from SLMPs was studied using different bioengineered human skin substitutes obtained by 3D-bioprinting. Finally, the antimicrobial activity of the SLMPs was evaluated against three relevant bacteria in wound infections (Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa). SLMPs processed with 10 wt.% of LID showed a remarkable performance to provide effective doses for pain relief and preventive infection effects.

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Section: Resultsmentioning

confidence: 88%

Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

et al. 2020

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A review and new insights to antimicrobial action of local anesthetics

Razavi

Bazzaz

2019

Eur J Clin Microbiol Infect Dis

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Local Anesthetics as Antimicrobial Agents: A Review

Johnson¹,

John²,

Dine³

2008

Surgical Infections

195

122

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Local anesthetics not only serve as agents for pain control, but possess antimicrobial activity as well. In such a capacity, local anesthetics can be considered as an adjunct to traditional antimicrobial use in the clinical or laboratory setting. Additionally, caution should be exercised when administering local anesthetics prior to diagnostic procedures in which culture specimens are to be obtained, as the antimicrobial activity of the local anesthetic could lead to false-negative results or suboptimal culture yields.

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Growth Inhibition of Staphylococcus Aureus by Propofol/Lidocaine Admixture

Cited by 7 publications

References 0 publications

Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

Lidocaine-Loaded Solid Lipid Microparticles (SLMPs) Produced from Gas-Saturated Solutions for Wound Applications

A review and new insights to antimicrobial action of local anesthetics

Local Anesthetics as Antimicrobial Agents: A Review

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