As an emerging lead-free packaging interconnect material, Nano-Ag paste exhibits superior high-temperature mechanical, electrical, and thermal properties. It can meet the stringent high-temperature and high-density packaging requirements of future high-power semiconductor devices and is garnering widespread attention. However, research on the high-temperature reliability of sintered joints remains rather limited. In this study, we fabricated high-strength hot-press sintered nano-Ag joints using a hot-press sintering process. These joints underwent aging at high temperatures of 200°C and 300°C, yielding insights into the variations in mechanical properties at different temperatures. The reasons behind joint failure were analyzed by investigating the evolution of joint microstructures and fracture surfaces. The results indicate that even after extended aging at 200°C, the joint strength can still be maintained at 176 MPa. However, after aging for over 100 hours at 300°C, the joint fails. The growth of Cu oxides was observed within the joint microstructure, which constitutes the primary cause of joint failure at 300°C.