Growth Pattern of Postnatally Developing Rat Parotid Gland

Ca, Schneyer; Hd, Hall

doi:10.3181/00379727-130-33617

Cited by 42 publications

(17 citation statements)

References 4 publications

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“…It is of interest that other tissues such as Brunner's glands of the duodenum [Obuoforibo and Martin, 1977] and the parotid gland [Schneyer and Hall, 1969;Redman and Sreebney, 1970], which have a very low mitotic activity in the adult show a high mitotic rate during the first 3 postnatal weeks, and by the end of that time the epithelial cells acquire adult characteristics.…”

Section: Discussionmentioning

confidence: 99%

Development and Maturation of the Bladder Epithelium of the Guinea Pig

Martin

Wong²

1981

Cells Tissues Organs

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In the fetal guinea pig, transitional epithelium develops at a little beyond midterm of gestation from a single layer of columnar cells. Some of the cells elongate and overlap their neighbors, but remain attached to the basement membrane by fine cytoplasmic stalks. The fetal epithelial cells do not markedly vary in size. Within the basal layer, which is the site of mitotic activity, many cells are large and binucleate, which suggests that basal cell fusions occur. It is believed that these cells eventually become surface cells. The luminal membrane develops its asymmetric structure (asymmetric unit membrane; AUM) following the appearance of AUM-bound vesicles in the apical cytoplasm, indicating that they are the source of the luminal AUM. The vesicles originate in the Golgi cisternae and are initially cup-shaped. The immature surface cells are characterized by microvilli of varying density on the luminal surface. The characteristic mature surface ridges appear to develop from rows of microvilli which fuse and link with other rows to form a reticular pattern. The process commences shortly after mid-gestation. By –15 to -10 days, the majority of cells have a well-developed surface pattern. Microvilli, however, remain prevalent in some small surface cells. These are believed to be the younger surface cells derived from pyriform intermediate cells, with the surface not fully differentiated. During the first 3 postnatal weeks, the basal cell population reaches the adult level and mitotic activity declines. The epithelium also acquires its adult morphology, whilst its functional maturity is indicated by the adult distribution and content of both glycogen, which is reduced, and alkaline phosphatase, which is increased. Rejection of cells occurs both antenatally and postnatally, and is probably a consequence of excess cell production.

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Section: Discussionmentioning

confidence: 99%

Development and Maturation of the Bladder Epithelium of the Guinea Pig

Martin

Wong²

1981

Cells Tissues Organs

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“…Offspring not sampled a t younger ages were weaned at 7 a.m. at age 21 days. Six ages were selected to represent significant developmental stages, as previously described (Ball, 1971;Lawson, 1970;Redman, 1987;Redman and Sreebny, 1970Schneyer and Hall, 1969). These were as follows: 20 days in utero (prenatal); 7 days (early postnatal); 14 days (initial solid food consumption); 21 days (weaning, with onset of strong circadian rhythms in feeding activity and secretion/storage of secretory proteins); 25 days (acinar maturation); and 40 days (mature gland).…”

Section: Materials and Methods Animalsmentioning

confidence: 99%

“…In addition, Dardick and Burford-Mason (1993) have immunohistochemically localized proliferating cell nuclear antigen (PCNA) to identify cycling cells in mature human and rat salivary glands. However, previous systematic investigations of proliferative activity in the developing rat parotid gland have been limited to the acinar cells (Klein, 1979(Klein, , 1982Klein and Whitney, 1980;Schneyer and Hall, 1969).…”

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confidence: 99%

Proliferative activity by cell type in the developing rat parotid gland

Redman

1995

Anat. Rec.

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Current theories on the histogenesis of salivary glands and their neoplasms are based on the renewing population model, in which both normal differentiated cells and neoplastic cells arise from undifferentiated stem cells in the ducts. However, these results suggest that most of the migration and redifferentiation in the developing rat parotid gland must be in the opposite direction, i.e., the acinar cells redifferentiate into ductal cells. They also indicate that until there are precise data on the rates of cell death among the several cell types, it remains more appropriate for salivary glands to be categorized as an expanding, rather than renewing, population.

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“…Volumes were calculated using density relationships determined in preliminary studies (parotid and submandibular saliva were found both to have a density of 1 mg/,ll, independent of flow rate). Saliva was not collected from rats younger than 49 days of age, as the parotid gland is not fully matured morphologically (Winick & Noble, 1965;Schneyer & Hall, 1969) or functionally (Schneyer & Hall, 1968) before this time in rats.…”

Section: Vitamin D and Parotid Gland Functionmentioning

confidence: 99%

Vitamin D and parotid gland function in the rat.

Peterfy

Tenenhouse

1988

The Journal of Physiology

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SUMMARY1. We previously reported that parotid gland secretion is decreased in rats deprived of vitamin D (Glijer, Peterfy & Tenenhouse, 1985). In the present study we examine whether this effect is a direct result of the absence of vitamin D or due to the secondary systemic effects of vitamin D deficiency.2. Offspring of rats maintained on a calcium-supplemented (1-2%), vitamin-Ddeficient diet were weaned onto the same diet and examined after 8 weeks. Using this method it was possible to maintain serum calcium and parathyroid hormone concentrations within normal limits. Serum 25-hydroxyvitamin D (25(OH)D3) was not detectable, but 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations were normal.3. Pilocarpine-stimulated flow of parotid saliva was reduced 57 % in vitamin-Ddeprived animals, but amylase secretion was unchanged. Treatment with vitamin D3 returned flow rates to normal.4. The concentration of calcium in parotid saliva was normal in vitamin-Ddeprived rats, although total parotid calcium output was reduced 57 %.5. Pilocarpine-stimulated salivary flow from submandibular gland, a tissue which does not possess 1,25(OH)2D3 receptors, was normal in vitamin-D-deprived rats.6. Heart rate and arterial blood pressure changes in response to i.v. pilocarpine administration were identical in normal and vitamin-D-deficient rats.7. Auriculotemporal nerve-stimulated flow of parotid saliva was also reduced by 50% and administration of vitamin D3 to these rats corrected this abnormality.8. It is concluded that fluid and electrolyte secretion from parotid gland is directly dependent on vitamin D; abnormal parotid gland function seen in vitamin-Ddeficient rats is not due to secondary hypocalcaemia or hyperparathyroidism, nor can it be explained by haemodynamic changes evoked during systemic administration of pilocarpine. We further conclude that the metabolite of vitamin D responsible for this effect is not 1,25(OH)2D3.

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Growth Pattern of Postnatally Developing Rat Parotid Gland

Cited by 42 publications

References 4 publications

Development and Maturation of the Bladder Epithelium of the Guinea Pig

Development and Maturation of the Bladder Epithelium of the Guinea Pig

Proliferative activity by cell type in the developing rat parotid gland

Vitamin D and parotid gland function in the rat.

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