Growth-promoting effect of bisphenol A on neuroblastoma in vitro and in vivo

Zhu, Haitao; Xiao, Xianmin; Zheng, Jicui; Zheng, Shan; Dong, Kuiran; Yu, Yong

doi:10.1016/j.jpedsurg.2008.10.067

Cited by 33 publications

(23 citation statements)

References 23 publications

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“…BPA, although less potent than -estradiol (E2), increases heat shock protein (hsp90 ) in the uteri of mice, and ICI 182,780 attenuates BPAand E2-induced increases in uterine hps90 levels 37) . Similar to E2, BPA promotes the growth of several types of cancer cells, and ICI 182,780 effectively abolishes the promoting effect 38,39) . As shown in Fig.…”

Section: Discussionmentioning

confidence: 97%

Bisphenol A Downregulates Akt Signaling and Inhibits Adiponectin Production and Secretion in 3T3-L1 Adipocytes

Kidani

Kamei

Miyawaki

et al. 2010

JAT

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Section: Discussionmentioning

confidence: 97%

Bisphenol A Downregulates Akt Signaling and Inhibits Adiponectin Production and Secretion in 3T3-L1 Adipocytes

Kidani

Kamei

Miyawaki

et al. 2010

JAT

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“…These observations are consistent with the present observation of a decreased proliferation potential of BPA-treated human ESF, which, together with the enhanced decidualized phenotype observed herein, suggests a progestational effect of BPA in the endometrium. In neuroblastoma and breast cancer cell lines, BPA promotes cell proliferation (Fernandez and Russo, 2010;Zhu et al, 2009Zhu et al, , 2010, indicating a complex and tissue specific effect of BPA.…”

Section: Serum Bpa and Tissue Proliferative Potentialmentioning

confidence: 99%

Effect of bisphenol A on human endometrial stromal fibroblasts in vitro

Aghajanova

Giudice

2008

Fertility and Sterility

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Francisco. Being a clinician with particular interest in reproduction, she has focused her research on human implantation and several factors affecting that process, particularly environmental, and biomarkers of uterine receptivity, as well as endometrial dysfunction in women with unexplained infertility and endometriosis.Abstract This study evaluated the effects of bisphenol A (BPA) on human endometrial stromal fibroblast (ESF) differentiation and expression of genes involved in oestrogen metabolism. Human ESF from eight hysterectomy specimens were cultured and treated with 5-100 lmol/l of BPA ± oestradiol or 8-br-cAMP for 48 h. mRNA expression was analysed by real-time reverse-transcription PCR. 8-br-cAMP-induced human ESF decidualization was confirmed by expression of insulin-like growth factor binding protein-1 (IGFBP1) and prolactin secretion. Short-term exposure (48 h) decreased human ESF proliferation (P < 0.04) not due to apoptosis. High doses of BPA significantly induced IGFBP1 mRNA and protein, decreased P450scc mRNA, reversed the 8-br-cAMP-induced increase in HSD17B2 (oestradiol to oestrone conversion) in a dose-dependent manner and down-regulated HSD17B1 expression (oestrone to oestradiol conversion; P 0.03). 8-br-cAMP significantly potentiated this effect (P = 0.028). BPA had no significant effect on aromatase and PPAR c expression. The oestrogen-receptor antagonist ICI had no effect on gene expression in BPA-treated cells, and oestrogen receptor a, but not oestrogen receptor b, was significantly down-regulated by high doses of BPA (P = 0.028). BPA has an endocrine-disrupting effect on human ESF function and gene expression but the underlying mechanisms appear not to involve oestrogen-mediated pathways.RBMOnline

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“…Our previous studies showed that SK-N-SH cells express b-estrogen receptor (ER), and BPA mimics the function of the endogenous estrogen to promote their growth, improves their invasion and metastasis by an ER-dependent pathway (Zheng et al, 2007;Zhu et al, 2009Zhu et al, , 2010. To efficiently analyze the effects of BPA on SP cells, we used E 2 , one of the most important estrogens, as a control in our experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, studies on the risk factors and mechanisms involved in the development of NB are urgently required to improve the treatment for this poorly understood cancer. In our previous studies, we showed that BPA promotes the proliferation of SK-N-SH NB cells and improves their invasion and metastasis (Zheng et al, 2007;Zhu et al, 2009Zhu et al, , 2010. Thus, we expect that BPA may play a role in the development of NB.…”

Section: Introductionmentioning

confidence: 95%

Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells

Zheng¹,

Qi²,

Yang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Bisphenol A (BPA) is an industrial contaminant and is reported to be a risk factor associated with the development of tumors. In our previous studies, we have shown that BPA promoted the growth of SK-N-SH human neuroblastoma cells and increased their invasion and metastasis. In this study, we further investigated the effects of BPA and 17b-estradiol (E 2 ) on the stem cell-like cells from SK-N-SH cells. Detection of stem cell markers, proliferation assay, and clonogenic analysis showed that the side-population (SP) of SK-N-SH cells had properties similar to those of stem cells. BPA or E 2 exposure decreased the percentage of SP cells and the expression of stem cell-marker proteins. BPA and E 2 promoted the growth of non-SP cells to a greater extent than of SP cells; in addition, they significantly increased the 2987 BPA promotes the growth of cancer stem cell-like SP cells ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 2986-2993 (2015 growth of SP cells. Thus, BPA has effects on stem cell-like cells, which induce tumor formation, and thus, BPA is an environmental factor that plays an important role in the development of neuroblastoma.

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Growth-promoting effect of bisphenol A on neuroblastoma in vitro and in vivo

Cited by 33 publications

References 23 publications

Bisphenol A Downregulates Akt Signaling and Inhibits Adiponectin Production and Secretion in 3T3-L1 Adipocytes

Bisphenol A Downregulates Akt Signaling and Inhibits Adiponectin Production and Secretion in 3T3-L1 Adipocytes

Effect of bisphenol A on human endometrial stromal fibroblasts in vitro

Effects of bisphenol A on decreasing the percentage and promoting the growth of stem cell-like cells from SK-N-SH human neuroblastoma cells

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