Groα-mediated recruitment of neutrophils is required for elicitation of contact hypersensitivity

Dilulio, Nancy A.; Engeman, Tara M.; Armstrong, David A.; Tannenbaum, Charles S.; Hamilton, Thomas A.; Fairchild, Robert L.

doi:10.1002/(sici)1521-4141(199911)29:11<3485::aid-immu3485>3.0.co;2-b

Cited by 84 publications

(96 citation statements)

References 35 publications

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“…Recent data obtained in the murine system suggested that Gro␣ expression and subsequent neutrophil infiltration are prerequisites for T cell recruitment and elicitation of the CHS reaction. 26 In the human CHS reaction, we could not only detect exclusive dermal Gro␣ expression but also simultaneous epidermal IL-8 and Gro␣ expression. This may explain why in humans neutrophils also infiltrate the epidermal compartment after 48 hours.…”

Section: Discussionmentioning

confidence: 86%

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Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity

Goebeler¹,

Trautmann²,

Voss³

et al. 2001

The American Journal of Pathology

165

150

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Regulation of chemokine-mediated leukocyte migration within inflammatory tissues is a complex event that cannot be mimicked and analyzed in vitro.Hapten-induced contact hypersensitivity (CHS) is a highly frequent, often occupationally related human skin disorder in industrialized countries with an enormous sociomedical impact. 1 Moreover, CHS is considered as a standard model for an antigen-specific, T-lymphocytemediated immune response. 2 This concept still holds true for the clinically nonapparent sensitization phase of CHS with antigen-processing and presentation by Langerhans cells and a consecutive T cell stimulation in the draining lymph node. However, there is increasing evidence that during the clinically visible and physically disturbing elicitation phase of CHS nonspecific hapten-induced proinflammatory effects precede or parallel the antigen-specific effect and are a conditio sine qua non for the vigorous inflammatory reactions. 2 In a mouse CHS model Grabbe and colleagues 3 demonstrated that nonspecific effects of epicutaneously applied haptens contribute to the elicitation of CHS. Proinflammatory irritative rather than antigen-specific properties of the hapten are furthermore responsible for the strict concentration-dependence of the effector phase of CHS. Therefore, it is tempting to speculate that such irritative properties of haptens promote inflammatory skin reactions via induction of proinflammatory cytokines, adhesion molecules, and chemoattractants. Accordingly, some contact allergens such as urushiol, the relevant hapten in poison ivy, and nickel sulfate have been demonstrated to directly induce inflammatory activation of keratinocytes resulting in expression of ICAM-1, interleukin (IL)-8, and/or tumor necrosis factor (TNF)-␣. 4 -6 In recent years, in particular chemokines have emerged as potent stimulators of effector cell accumulation and activation and are likely candidates to mediate leukocyte recruitment during elicitation of CHS. Since the description of IL-8 more than a decade ago, the supergene Supported by grants from the W. Sander-Stiftung (95.064.2) (to R. G.) and from the Deutsche Forschungsgemeinschaft (811/1-3) to M. G. M. G. and A. Trautmann contributed equally to this work.

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Section: Discussionmentioning

confidence: 86%

“…This may explain why in humans neutrophils also infiltrate the epidermal compartment after 48 hours. Whether neutrophils recruited to the skin are a prerequisite for subsequent T cell trafficking as proposed by Dilulio and colleagues 26 remains to be elucidated for the human system.…”

Section: Discussionmentioning

confidence: 99%

Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity

Goebeler¹,

Trautmann²,

Voss³

et al. 2001

The American Journal of Pathology

165

150

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“…This antiserum reacts with KC and not with other CXC chemokines including IP-10 and Mig in Western blot analyses and inhibits recombinant KC-mediated chemotaxis of thioglycolate-induced peritoneal neutrophils in in vitro chemotaxis assays (Ref. 20 and data not shown). Normal rabbit serum (NRS) was used as control Ig for in vivo Ab treatment experiments.…”

Section: Abs and Antiserummentioning

confidence: 91%

Early Chemokine Cascades in Murine Cardiac Grafts Regulate T Cell Recruitment and Progression of Acute Allograft Rejection

Morita¹,

Miura

Paolone³

et al. 2001

The Journal of Immunology

Self Cite

131

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The identification of early inflammatory events after transplant in solid tissue organ grafts that may direct T cell recruitment and promote acute allograft rejection remain largely unknown. To better understand temporal aspects of early inflammatory events in vascularized organ grafts, we tested the intragraft expression of four different chemokines in heterotopically transplanted A/J (H-2a) and syngeneic heart grafts in C57BL/6 (H-2b) recipient mice from 1.5 to 48 h after transplant. Similar temporal expression patterns and equivalent levels of chemokine expression were observed in both syngeneic and allogeneic cardiac allografts during this time period. Expression of the neutrophil chemoattractant growth-related oncogene α (KC) was observed first and reached peak levels by 6 h after transplant and was followed by the monocyte/macrophage chemoattractant protein-1 (JE) and then macrophage inflammatory proteins 1β and 1α. Administration of rabbit KC antiserum to allograft recipients within 30 min of cardiac transplantation attenuated downstream events including intra-allograft expression of the T cell chemoattractants IFN-γ-inducible protein-10 and monokine induced by IFN-γ, cellular infiltration into the allograft, and graft rejection. Similarly, depletion of recipient neutrophils at the time of transplantation significantly extended allograft survival from day 8 to 10 in control-treated recipients up to day 21 after transplant. These results indicate the induction of highly organized cascades of neutrophil and macrophage chemoattractants in cardiac grafts and support the proposal that early inflammatory events are required for optimal recruitment of T cells into allografts during the progression of acute rejection of cardiac allografts.

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“…After antigen-specific activation and clonal expansion in the lymph nodes, effector T cells migrate to the skin where upon challenge they mediate inflammation and swelling (Gorbachev and Fairchild 2001). At the site of hapten challenge, there is recruitment of neutrophils and the production of proinflammatory cytokines (Dilulio et al 1999;Kish et al 2009). Curiously, there was no evidence of neutrophil infiltration or cytotoxic molecules at the site of hapten challenge in the case of NK cell-mediated contact hypersensitivity (Rouzaire et al 2012).…”

Section: Insights Into the Mechanism Of Nk Cell Memory In Contact Hypmentioning

confidence: 99%

Sweet Is the Memory of Past Troubles: NK Cells Remember

Hendricks

Min‐Oo

Lanier

2015

Natural Killer Cells

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Natural killer (NK) cells are important in host defense against tumors and microbial pathogens. Recent studies indicate that NK cells share many features with the adaptive immune system, and like B cells and T cells, NK cells can acquire immunological memory. Here, we review evidence for NK cell memory and the molecules involved in the generation and maintenance of these self-renewing NK cells that provide enhanced protection of the host.

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Groα-mediated recruitment of neutrophils is required for elicitation of contact hypersensitivity

Cited by 84 publications

References 35 publications

Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity

Differential and Sequential Expression of Multiple Chemokines during Elicitation of Allergic Contact Hypersensitivity

Early Chemokine Cascades in Murine Cardiac Grafts Regulate T Cell Recruitment and Progression of Acute Allograft Rejection

Sweet Is the Memory of Past Troubles: NK Cells Remember

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