GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

Plátenı́k, Jan; Fišar, Zdeněk; Buchal, Richard; Jirák, Roman; Kitzlerová, Eva; Zvěřová, Martina; Raboch, Jiří

doi:10.1016/j.pnpbp.2013.12.001

Cited by 146 publications

(103 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results suggest the involvement of BDNF with cognitive dysfunction in AD patients [31]. Another studies have shown BDNF levels diminished in AD patients as compared to controls [32][33][34][35][36][37]. Lee (2009) also observed a BDNF levels decrease in both AD and MCI patients [38].…”

Section: Bdnf and Alzheimer's Diseasementioning

confidence: 75%

“…Increased GSK3B and CREB activity was found in AD patients with depressive symptoms. This increase in CREB can be explained by the presence of depressive symptoms in these patients or because of low BDNF levels in patients suffering with depression [33]. These changes in the levels of BDNF may be well related to the several stages of AD pathology.…”

Section: Bdnf and Alzheimer's Diseasementioning

confidence: 97%

See 1 more Smart Citation

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Budni¹,

Bellettini-Santos²,

Mina³

et al. 2015

Aging and disease

339

188

View full text Add to dashboard Cite

Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cellderived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event. Considering that aging and AD are related to cognitive impairment, here we discuss the involving these neurotrophic factors in the aging process and AD.

show abstract

Section: Bdnf and Alzheimer's Diseasementioning

confidence: 75%

Section: Bdnf and Alzheimer's Diseasementioning

confidence: 97%

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Budni¹,

Bellettini-Santos²,

Mina³

et al. 2015

Aging and disease

339

188

View full text Add to dashboard Cite

show abstract

“…Increase in GSK-3β activity results from up-regulation of GSK-3β gene expression or down-regulation of GSK-3β phosphorylation and hence decrease in the ratio between phosphorylated GSK-3β and total GSK-3β. Evidence for the involvement of GSK-3β in major depression is obtained from both animal models (Szymańska et al 2009) and depressed patients (Pláteník et al 2014). Increase in GSK-3β activity in depressed animals can be reversed by treatment with SSRIs.…”

Section: Discussionmentioning

confidence: 99%

“…In postmortem prefrontal cortex of patients with MDD and MDD with suicide, the level of phosphorylated GSK-3β was decreased (Karege et al 2012). In elderly depressed patients and Alzheimer's disease patients with depression, a lower level of phosphorylated GSK-3β in platelets correlated with severity of depression (Diniz et al 2011;Pláteník et al 2014). …”

Section: Discussionmentioning

confidence: 99%

Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine

Bai

Song

et al. 2017

Psychopharmacology

View full text Add to dashboard Cite

Here we present the data indicating that chronic treatment with fluoxetine regulates Cav-1/PTEN/PI3K/AKT/GSK-3β signalling pathway and glycogen content in primary cultures of astrocytes with bi-phasic concentration dependence. At lower concentrations fluoxetine down-regulates gene expression of Cav-1, decreases membrane content of PTEN, increases activity of PI3K/AKT, and elevates GSK-3β phosphorylation thus suppressing its activity. At higher concentrations fluoxetine acts in an inverse fashion. As expected, fluoxetine at lower concentrations increased while at higher concentrations decreased glycogen content in astrocytes. Our findings indicate that bi-phasic regulation of glycogen content via Cav-1/PTEN/AKT/GSK-3β pathway by fluoxetine may be responsible for both therapeutic and side effects of the drug.

show abstract

“…Na área da saúde mental, as doenças neuropsiquiátricas, como as demências e a depressão assumem um papel de grande destaque, com o avançar da idade (Pláteník et al, 2014;Pocinho, 2007;Williams & Kemper, 2010), ameaçando a independência e a qualidade de vida dos idosos (Colasanti, Marianetti, Micacchi, Amabile, & Mina, 2010;Williams & Kemper, 2010).…”

Section: Introductionunclassified

Interação entre a idade, escolaridade, tempo de institucionalização e exercício físico na função cognitiva e depressão em idosos

2016

View full text Add to dashboard Cite

RESUMOO objetivo deste estudo foi verificar o efeito e interação entre a idade, escolaridade, institucionalização e exercício físico na função cognitiva e depressão em Idosos. Foi utilizada uma amostra constituída por 39 idosos institucionalizados (33 mulheres e 6 homens), com idades compreendidas entre os 64-96 anos (82.13±6.66). Os instrumentos de avaliação utilizados foram: Mini Mental State Examination, Escala de Depressão Geriátrica, Matrizes Progressivas Coloridas de Raven e um questionário sociodemográfico. Para verificar o efeito e a interação entre variáveis, foi aplicado o modelo geral linear, introduzindo como covariável o tempo de institucionalização, e como variáveis fator a idade (<85 anos; ≥85 anos), a escolaridade (analfabetos; 1ºciclo) e a prática de exercício. Os resultados demonstraram um efeito significativo do tempo de institucionalização (p= 0.003) na depressão; e da escolaridade na função cognitiva (p= 0.030). Os resultados da interação escolaridade x idade foram significativos na função cognitiva (p= 0.010) e na capacidade intelectual (p= 0.032). Os indivíduos mais velhos e com nível de escolaridade superior apresentaram resultados mais elevados na função cognitiva e na capacidade intelectual. Podemos concluir que em idosos mais velhos, a escolaridade é a variável mais determinante da função cognitiva, enquanto a depressão depende do tempo de institucionalização.Palavras-chaves: idosos, função cognitiva, depressão, escolaridade, institucionalização, exercício físico ABSTRACT The purpose of this study was verifying the effect and interaction between age, schooling, institutionalisation and physical exercise in the cognitive function and depression in the elderly. The study comprised 39 institutionalized senior citizens (33 females and 6 males) aged between 64 and 96 (82.13±6.66). We used as evaluation tools: Mini Mental State Examination, Geriatric Depression Scale, Raven's Coloured Progressive Matrices and a socio-demographic questionnaire. In order to understand the effect and interaction between variables we used the General Linear Model, introducing the time of institutionalization as a co-variable, and age (<85 years; ≥85 years), schooling (illiterate; 1st cycle of basic education) and physical exercise as variables. The results revealed a statistically significant difference regarding the time of institutionalization when dealing with depression (p= 0.003); and regarding schooling in the cognitive function (p= 0.030). Also, results concerning schooling versus age were significantly different in the cognitive function (p= 0.010) and intellectual ability (p= 0.032). Older individuals with higher levels of education presented superior results regarding the cognitive function and intellectual ability. We can thus infer that when it comes to older seniors schooling is the most decisive variable of the cognitive function, while depression depends on the time of institutionalization.

show abstract

GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

Cited by 146 publications

References 92 publications

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

Bi-phasic regulation of glycogen content in astrocytes via Cav-1/PTEN/PI3K/AKT/GSK-3β pathway by fluoxetine

Interação entre a idade, escolaridade, tempo de institucionalização e exercício físico na função cognitiva e depressão em idosos

Contact Info

Product

Resources

About