Guanase activity in endemic balkan nephropathy

Prodanov, K; Astrug, A

doi:10.1016/0009-8981(71)90219-1

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…We identified 1251 AAN-related records. The first article relating to AAN was published in 1971 by Prodanov and Astrug [15] . Since then, the number of publications on AAN has gradually increased each year until 2000, after which there was an exponential growth in the past 2 decades (Fig.…”

Section: Resultsmentioning

confidence: 99%

Aristolochic acid nephropathy

Zhang

et al. 2021

Medicine

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Section: Resultsmentioning

confidence: 99%

Aristolochic acid nephropathy

Zhang

et al. 2021

Medicine

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“…Increased serum guanase activities in hepatic disorders have al ready been demonstrated in a number of publi cations (1,3,12,19). Furthermore, it was reported that guanase determinations are of diagnostic value in patients with renal diseases (7,14). It could, however, not be elucidated whether the renal lesions or dystrophy of liver cells were responsible for the increased serum guanase activities.…”

Section: Resultsmentioning

confidence: 99%

“…An increase of serum guanase activity in cases with acute viral hepatitis (1,12,19), renal diseases (7,14) and myo cardial infarction (5) could also be demon strated.…”

Section: Introductionmentioning

confidence: 96%

Evaluation of Serum Guanase in Hepatic Diseases

Kuzmits¹,

Seyfried²,

Wolf³

et al. 1980

Enzyme

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Serum guanase activity was measured in 20 healthy adults and in 62 patients with acute viral hepatitis, chronic active hepatitis, chronic persistent hepatitis, liver cirrhosis and fatty liver. Guanase and γ-GT in patients were elevated in 87 and 64%, respectively. Elevated guanase activities were found in most cases of acute viral hepatitis, as well as in chronic hepatopathies. In patients with acute viral hepatitis pathologic activities of guanase were found following partial or total normalization of other liver function tests.

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“…To date, most studies relating to GDA function have focused on its role in maintenance of homeostasis of triphosphate nucleotides, its role as a nitrogen source, its signal transduction pathway, and, lately, on its role in neuronal development. Although serum GDA function is often altered in kidney diseases (Caraway, 1966; Prodanov and Astrug, 1971; Kebejian and al-Khalidi, 1973; Kuzmits et al, 1980), whether GDA functions during kidney development or maintenance had not been addressed. Xenopus begin developing a primitive kidney called pronephroi by stage 12.5, which becomes fully functional by stage 38, approximately 2 days post-fertilization.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney

Slater

Cammarata

Monahan

et al. 2019

Developmental Dynamics

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The mammalian guanine deaminase (GDA), called cypin, is important for proper neural development, by regulating dendritic arborization through modulation of microtubule (MT) dynamics. Additionally, cypin can promote MT assembly in vitro. However, it has never been tested whether cypin (or other GDA orthologs) binds to MTs or modulates MT dynamics. Here, we address these questions and characterize Xenopus laevis GDA (Gda) for the first time during embryonic development. We find that exogenously-expressed human cypin and Gda both display a cytosolic distribution in primary embryonic cells. Furthermore, while expression of human cypin can promote MT polymerization, Xenopus Gda has no effect. Additionally, we find that the tubulin-binding CRMP homology domain is only partially conserved between cypin and Gda. This likely explains the divergence in function, as we discovered that the cypin region containing the CRMP homology and PDZ-binding domain is necessary for regulating MT dynamics. Finally, we observed that gda is strongly expressed in the kidneys during late embryonic development, although it does not appear to be critical for kidney development. Together, these results suggest that GDA has diverged in function between mammals and amphibians, and that mammalian GDA plays an indirect role in regulating MT dynamics.

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Guanase activity in endemic balkan nephropathy

Cited by 9 publications

References 7 publications

Aristolochic acid nephropathy

Aristolochic acid nephropathy

Evaluation of Serum Guanase in Hepatic Diseases

Characterization of Xenopus laevis guanine deaminase reveals new insights for its expression and function in the embryonic kidney

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