Guanidine Alkaloids from Marine Invertebrates

Berlinck, Roberto G. S.; Kossuga, M. H.

doi:10.1002/9783527621071.ch11

Cited by 8 publications

(6 citation statements)

References 231 publications

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“…The extracts analysed here showed strong antibacterial, antimycobacterial and cytotoxic activities, probably due to the presence of guanidine alkaloids tipically isolated from Monanchora spp. and other Poescilosclerida sponges (reviewed in Berlinck and Kossuga, 2005;Berlinck and Kossuga, 2007). Up to the present, only isoptilocaulin (22) has been isolated from Monanchora sp.…”

Section: Marine Spongesmentioning

confidence: 99%

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Seleghim¹,

Lira²,

Kossuga³

et al. 2007

Rev. bras. farmacogn.

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Section: Marine Spongesmentioning

confidence: 99%

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Seleghim¹,

Lira²,

Kossuga³

et al. 2007

Rev. bras. farmacogn.

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“…Lupa potentiates glucose-stimulated insulin release by directly affecting KATP channels [19 Overall, sparteine and lupanine are the most studied QAs, while cytisine is well e lished in Eastern Europe and Canada for smoking cessation [21]. Moreover, all alka occurring in Lupinus have both biological and ecological significance and also consid to be taxonomical markers [22]. Another relevant function of QAs is their use as fertil for some crops.…”

Section: Introductionmentioning

confidence: 99%

Quantitation of Lupinus spp. Quinolizidine Alkaloids by qNMR and Accelerated Debittering with a Resin-Based Protocol

Madelou,

Melliou,

Magiatis

2024

Molecules

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Quinolizidine alkaloids (QAs) are toxic secondary metabolites of the Lupinus species, the presence of which limits the expansion of lupin beans consumption, despite their high protein content. Evaluation of the level of alkaloids in edible Lupinus species is crucial from a food safety point of view. However, quantitation of QAs is complicated by the fact that not all important alkaloids used for quantitation are commercially available. In this context, we developed a method for the simultaneous quantitation of eight major lupin alkaloids using quantitative NMR spectroscopy (qNMR). Quantitation and analysis were performed in 15 different seed extracts of 11 Lupinus spp. some of which belonged to the same species, with different geographical origins and time of harvest, as well as in all aerial parts of L. pilosus. The mature seeds of L. pilosus were found to be a uniquely rich source of multiflorine. Additionally, we developed a protocol using adsorption or ionic resins for easy, fast, and efficient debittering of the lupine seeds. The protocol was applied to L. albus, leading to a decrease of the time required for alkaloids removal as well as water consumption and to a method for QA isolation from the debittering wastewater.

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“…N -Arylated heterocyclic compounds are significant organic structural frameworks in various natural products 1 and drugs 2 and they also serve as precursors in aromatic heterocyclic synthesis. 3 2-Aminobenzothiazole derivatives have extensive applications in pharmaceutical chemistry due to their beneficial medicinal properties like anticancer, 4 antidiabetic, 5 antitubercular 6 etc.…”

Section: Introductionmentioning

confidence: 99%

Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature

Radhika,

Chandravarkar,

Anilkumar

2023

RSC Adv.

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Guanidine Alkaloids from Marine Invertebrates

Cited by 8 publications

References 231 publications

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Antibiotic, cytotoxic and enzyme inhibitory activity of crude extracts from Brazilian marine invertebrates

Quantitation of Lupinus spp. Quinolizidine Alkaloids by qNMR and Accelerated Debittering with a Resin-Based Protocol

Cu(ii)-catalyzed C–N coupling of 2-aminobenzothiazoles with boronic acids at room temperature

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