Guanidine hydrochloride polymer additive to undertake ultraconservative resin infiltrant against Streptococcus mutans

Collares, Fabrício Mezzomo; García, Isadora Martini; Bohns, Fabio Rocha; Motta, Amanda de Souza da; Melo, Mary Anne Sampaio de; Leitune, Vicente Castelo Branco

doi:10.1016/j.eurpolymj.2020.109746

Cited by 11 publications

(10 citation statements)

References 41 publications

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“…A small sample of literature reports on the subject of cytotoxicity in the area of infiltrants prompted the authors to undertake research in this field [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Study of Cytotoxic Properties of an Experimental Preparation with Features of a Dental Infiltrant

et al. 2021

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Microinvasive dentistry is based on the treatment of early carious lesions with the use of dental infiltrants. The commercially available Icon dental infiltrant does not contain any bacteriostatic component. An experimental preparation enriched with the missing component was synthesised. The aim of this study was to evaluate the cytotoxicity of the experimental preparation. Mouse fibroblasts of the L-929 lineage were used for the in vitro study. Cell morphology and viability were assessed. In the cytotoxicity analysis, it was shown that the experimental preparation (42.8 ± 10.3) after 24 h at two-fold dilution showed similar cytotoxicity to Icon (42.7 ± 8.8) (p > 0.05), while at four-fold dilution experimental preparation (46.7 ± 3.1), it was less toxic than Icon (34.2 ± 3.1) (p < 0.05). The experimental preparation has the potential to provide an alternative to the Icon commercial preparation. Further research is needed to evaluate the cytotoxicity of the experimental preparation over a longer period of time.

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“…A small sample of literature reports on the subject of cytotoxicity in the area of infiltrants prompted the authors to undertake research in this field [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Study of Cytotoxic Properties of an Experimental Preparation with Features of a Dental Infiltrant

et al. 2021

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“…The resin infiltrants were formulated by mixing 90 wt% of triethylene glycol dimethacrylates (TEGDMA) with 10 wt% of bisphenol A-glycidyl methacrylate (Bis-GMA) according to the previous study of resin infiltrant formulation [ 17 ]. A photoinitiator system composed of camphorquinone and ethyl 4-dimethylaminobenzoate were added at 1 mol%.…”

Section: Methodsmentioning

confidence: 99%

“…Antimicrobial agents have been added to resin infiltrants to improve their biological properties and increase their protective effect. Previous studies incorporated silver nanoparticles (AgNP) [ 15 ], quaternary ammonium methacrylate [ 16 ], cationic molecules [ 17 ], and chlorhexidine into resin infiltrants formulation. AgNP were incorporated into a commercial infiltrant at 5.5 wt% and tested regarding enamel's penetrability [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Ionic liquid-loaded microcapsules doped into dental resin infiltrants

Cuppini

García

Souza

et al. 2021

Bioactive Materials

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Resin infiltrants have been effectively applied in dentistry to manage non-cavitated carious lesions in proximal dental surfaces. However, the common formulations are composed of inert methacrylate monomers. In this study, we developed a novel resin infiltrant with microcapsules loaded with an ionic liquid (MC-IL), and analyzed the physical properties and cytotoxicity of the dental resin. First, the ionic liquid 1- n -butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (BMI.NTf 2 ) was synthesized. BMI.NTf 2 has previously shown antibacterial activity in a dental resin. Then, MC-IL were synthesized by the deposition of a preformed polymer. The MC-IL were analyzed for particle size and de-agglomeration effect via laser diffraction analysis and shape via scanning electron microscopy (SEM). The infiltrants were formulated, and the MC-IL were incorporated at 2.5%, 5%, and 10 wt%. A group without MC-IL was used as a control. The infiltrants were evaluated for ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity. The MC-IL showed a mean particle size of 1.64 (±0.08) μm, shriveled aspect, and a de-agglomeration profile suggestive of nanoparticles' presence in the synthesized powder. There were no differences in UTS among groups (p > 0.05). The incorporation of 10 wt% of MC-IL increased the contact angle (p < 0.05), while the addition from 5 wt% reduced the SFE in comparison to the control group (p < 0.05). The human cell viability was above 90% for all groups (p > 0.05). The incorporation of microcapsules as a drug-delivery system for ionic liquids may be a promising strategy to improve dental restorative materials.

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“…This molecule has a high solubility in water, and the benefit of been colorless and odorless [20][21][22] . In dentistry, PHMGH was added into different blends to formulate restorative materials such as dental sealants 23 and resin infiltrants 24 . In both studies, the resins with PHMGH showed antibacterial activity against other important microorganisms involved in an oral disease (caries): Streptococcus mutans.…”

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confidence: 99%

Avaliação de soluções antifúngicas de guanidina para resina base de dentadura: um estudo in vitro

Gama

Leitune

García

et al. 2020

R. Fac. Odontol. Porto Alegre

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Background: The purposes of this study were: (1) to formulate polyhexamethylene guanidine hydrochloride (PHMGH) solutions at different concentrations; (2) to evaluate their antifungal activity against a mature biofilm of Candida albicans on acrylic resins; (3) to evaluate possible effects on acrylic resins flexural strength and surface roughness. Methods: PHMGH solutions were formulated with distilled water and 0.125, 0.250, or 0.5 wt.% of PHMGH. One group without PHMGH was used as control. For antifungal activity analysis, acrylic resin specimens were contaminated with C. albicans. Specimens were immersed in PHMGH solutions or distilled water for 5 or 10 min. Ultimate flexural strength and surface roughness of acrylic resins were evaluated. Results: All PHMGH solutions at 5 or 10 min showed antifungal activity compared to the control group (p

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Guanidine hydrochloride polymer additive to undertake ultraconservative resin infiltrant against Streptococcus mutans

Cited by 11 publications

References 41 publications

Study of Cytotoxic Properties of an Experimental Preparation with Features of a Dental Infiltrant

Study of Cytotoxic Properties of an Experimental Preparation with Features of a Dental Infiltrant

Ionic liquid-loaded microcapsules doped into dental resin infiltrants

Avaliação de soluções antifúngicas de guanidina para resina base de dentadura: um estudo in vitro

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