2011
DOI: 10.1021/cr100423x
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Guanylated Diamines, Triamines, and Polyamines: Chemistry and Biological Properties

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Cited by 105 publications
(56 citation statements)
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“…Please note that, depending on the substituents R, R′, and R′′, several isomers (tautomers) are conceivable. Mono‐ (R=R′=R′′=H) and persubstituted (R or R′ or R′′≠H) bis(guanidine)s are beyond the scope of this review, but have been discussed elsewhere, wherefore compounds with one to three hydrogen atoms per guanidine unit are discussed in the following.…”
Section: Bis(guanidine)smentioning
confidence: 99%
See 1 more Smart Citation
“…Please note that, depending on the substituents R, R′, and R′′, several isomers (tautomers) are conceivable. Mono‐ (R=R′=R′′=H) and persubstituted (R or R′ or R′′≠H) bis(guanidine)s are beyond the scope of this review, but have been discussed elsewhere, wherefore compounds with one to three hydrogen atoms per guanidine unit are discussed in the following.…”
Section: Bis(guanidine)smentioning
confidence: 99%
“…[59, 60a] In the second approach (ix), ab is(carbodiimide), which is either generated from the bis(thiourea) or from bis(iminophosphorane), is reacted with an excess of amine yieldingt he related macrocyclic bis(guanidine)si nv ery good yields. [75] Compared with bis(amidine)s, bis(guanidine)s found multifarious applicationsa sc atalysts, [59,76] ions ensors, [60] pharmaceuticals, [63] or superbases. [61] To some extent, bis(guanidine) complexes (Figure 15) resemble the coordination patterns observed for bis(amidinate)s. Mononuclear complexes of type A are known for Eu, [77] Nd, [78] Sm, [79] Ta, [80] Ti, [68b] Y, [78,81] Yb, [78,81,82] Zr, [68b] and have been either directly derived from the bis(guanidine) [68b] or from in situ generated dinuclearalkali-metal complexes, [77][78][79][80][81] which are readily accessible from the reactiono f metallated secondary diamines with two equivalents of ac ar- Review bodiimide.…”
Section: Bis(guanidine)smentioning
confidence: 99%
“…[9][10] We recently discovered both macrocyclic and linear amidinurea derivatives endowed with antifungal 11 and antiviral activity. 12 Some amidinurea derivatives also showed anti-proliferative properties 13 probably due to their ability to mimicking the natural nucleobases and thus to interact with DNA.…”
Section: D (N-[n-[8-[[n-(morpholine-4-carbonyl)carbamimidoyl] Amino]mentioning
confidence: 99%
“…The guanidine group is a common key unit in various natural and synthetic compounds demonstrating antimicrobial, antiviral, and antitumor activities [11]. Furthermore, because of high basicity (pKa 13.5), the guanidinium group is important for selective delivery of cytotoxic molecules to tumor cells [12].…”
Section: Introductionmentioning
confidence: 99%