Guar gum and sesame oil based novel bigels for controlled drug delivery

Singh, Vinay Kumar; Banerjee, Indranil; Agarwal, Tarun; Pramanik, Krishna; Bhattacharya, Mrinal; Pal, Kunal

doi:10.1016/j.colsurfb.2014.09.056

Cited by 136 publications

(80 citation statements)

References 61 publications

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“…In contrast to the results of our study, Singh et al [4] found that bigels with a higher proportion of organogel remained stable at high temperatures and maintained their structural organization. According to the authors, the long alkyl hydrocarbon chain of SMS may be the stabilizing factor in this formulation.…”

Section: Discussioncontrasting

confidence: 99%

“…The stable state of organogels depends on: (i) hydrogen bonding; (ii) van der Waals forces as transient forces; (iii) and the mechanism of fiber growth, which is influenced by the nature of the liquid portion of the gel [30]. The presence of almond oil used in the current study may explain the difference in the physical stability of BG40 and the bigel obtained by Singh et al [4], along with some technological differences in the preparation and storage of bigels. Rogers et al [30] found that differences in the physicomechanical characteristics of the examined organogels can be explained by the fiber growth model, as well as the storage temperature.…”

Section: Discussionmentioning

confidence: 69%

“…Olive oil [2], sesame oil [4,5], sunflower oil [6], soybean oil [1,7] and fish oil [8,9] are the most commonly used oils for bigel preparation. Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…Oleogels prepared from these oils are combined with hydrogels of natural and synthetic polymers: guar gum [4], gelatine [1], sodium alginate, hydroxypropyl methylcellulose [8], and carbopol [5,9].…”

Section: Introductionmentioning

confidence: 99%

“…Sorbitan monostearate (Span® 60, SMS, hydrophilic-lipophilic balance value 4.7) is a hydrophobic nonionic surfactant used in pharmaceutical formulations as a water-in-oil emulsifying agent. This compound gels several organic solvents, as well as a range of vegetable oils [4,5,12]. The aim of this study was to obtain and evaluate carbopol hydrogel/SMS-almond oil based organogel biphasic formulations (bigels) as a vehicle for semi-solid drug formulations with a topical application.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Andonova¹,

Peneva²,

Apostolova³

et al. 2017

Trop. J. Pharm Res

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Andonova¹,

Peneva²,

Apostolova³

et al. 2017

Trop. J. Pharm Res

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Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Gosecka

Gosecki

Jaworska‐Krych

2023

Adv Funct Materials

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Hydrogels, as 3D networks containing huge amount of water, display similarity to soft tissues, and thus they are of wide interest in tissue engineering. Hydrogels, due to biocompatibility and porous structure, are valuable therapeutic platforms for hydrophilic drugs. Over the last decade, there has been a strong emphasis on the development of hydrogel platforms with the ability to increase the solubility of hydrophobic drugs. However, the pronounced discrepancy between the hydrophilic character of hydrogels and the hydrophobic nature of numerous pharmacologically active compounds is problematic. In recent years, different strategies are applied using special polymer constructs or composite materials exploiting the advanced scientific knowledge in the area of polymer and lipid‐based nano‐ and microcarriers hydrophobization of the hydrogel turns out to be not only valuable in terms of achieving the ability to dissolve poorly soluble drugs in water, but also proves to be crucial in obtaining bioadhesion in wet conditions, but also, unexpected abnormal water swelling behavior, as well as in mechanical properties such as the dissipation mechanism and self‐healable hydrogel properties. This review is mainly focused on recent advances in the usage of hydrophobized hydrogels in biomedical applications.

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Influence of Aqueous Matrices into Candelilla Wax Organogels Emulsions for Topical Applications

Botega

Nogueira

Moura

et al. 2020

J Americ Oil Chem Soc

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Emulgels and bigels are, respectively, partial and total gelified forms of emulsions that can increase stability and bring different permeation and diffusion properties for traditional oil and water mixtures. This work investigated the stability, rheological behavior, and microstructure of bigels and emulgels through a topical application perspective. Candelilla wax (CW)/sunflower oil (5/95) organogels or pure sunflower oil was used to obtain dilute (5% oily phase) and concentrated (40% oily phase) emulsions. It was used three different aqueous phases with each oily phase and oil load: water, sodium polyacrylate hydrogel, and modified starch hydrogel. Dilute emulsions showed better stability with sodium polyacrylate hydrogel forming oil‐in‐water bigels and emulgels while concentrated emulsions were stable only in water‐in‐oil emulgels. Thixotropy, network strength, and thermal stability were modulated by the oily phase and concentration used. Concentrated emulgels showed higher spreadability, but strong temperature‐dependency. Diluted emulgels and bigels showed high hydrogel influence on stability and rheological properties observed. The results showed the potential of CW organogels to stabilize and modify sensory attributes in bigels and emulgels for topical applications.

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Guar gum and sesame oil based novel bigels for controlled drug delivery

Cited by 136 publications

References 61 publications

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Carbopol hydrogel/sorbitan monostearate-almond oil based organogel biphasic formulations: Preparation and characterization of the bigels

Hydrophobized Hydrogels: Construction Strategies, Properties, and Biomedical Applications

Influence of Aqueous Matrices into Candelilla Wax Organogels Emulsions for Topical Applications

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