Guar Gum Reduces Trichloroethylene Accumulation in the Body by Reducing TCE Absorption and Fat Tissue Mass

Abstract

Two studies were conducted regarding the effects of guar gum on accumulation and metabolism of trichloroethylene (TCE). In study 1, 6- and 14-weeks-old rats were given a single oral dose of 100 mg of trichloroethylene (TCE). Ten hours after administration of TCE, a marked positive correlation was noted between relative fat tissue weights and TCE distribution in fat tissues. Therefore, a small mass of fat tissue apparently limited TCE accumulation. In study 2, each of four groups of rats was fed one of four diets: cellulose-soybean oil, cellulose-docosahexaenoic acid (DHA), guar gum-soybean oil, or guar gum-DHA for 3 weeks and then all were given TCE as in study 1. The rate of decrease of TCE distributed in fat tissues of groups fed guar gum compared with corresponding groups fed cellulose was greater than the rate of decrease in relative weight of these tissues. TCE absorption by groups fed guar gum decreased 12% compared with TCE absorption of corresponding groups fed cellulose. Therefore, guar gum decreased TCE accumulation in the body by reducing TCE absorption and fat tissue mass.

High-Fat Diet Enhances the Accumulation of Hexachlorobenzene (HCB) by Pregnant Rats during Continuous Exposure to HCB

“…In studies 1 and 2, we observed that the total amount of HCB accumulated in the fat tissues and liver of the pregnant rats fed the high-fat diet was higher than that of the rats fed the control diet (Tables 3 and 5). In a previous paper, we have already noted a marked positive correlation between the relative fat tissue weight and the distribution of trichloroethylene in perirenal and epididymal fat tissue (24). In this study, because of the increase of these fat tissue weights of the pregnant rats fed the high-fat diet (Table 5), it was considered that large amounts of HCB had accumulated in these fat tissues of the pregnant rats.…”

“…In previous papers, we observed that dietary fiber, especially viscous indigestible polysaccharides, decreased the accumulation of lipophilic organochlorine chemicals in the body by reducing the absorption of these compounds and the fat tissue mass ( , ). We fed pregnant rats a high-fat diet to which was added a large amount of cellulose to maintain a constant metabolizable energy concentration in this study.…”

Partially hydrolyzed guar gum supplement reduces high-fat diet increased blood lipids and oxidative stress and ameliorates FeCl3-induced acute arterial injury in hamsters

“…Guar gum with viscous hydrocolloids may reduce the rate of gastric emptying and the diffusion of nutrients to the mucosa of the small intestine and increase cecal output [ 18 ]. For example, guar gum changed bile acid pools and intestinal reabsorption to lower cholesterols [ 19 ] and decreased trichloroethylene accumulation in the body by reducing trichloroethylene absorption and fat tissue mass [ 20 ]. In our study, PHGG supplement seems to have a tendency to depress HF increased caloric intake.…”

Dietary Guar Gum Reduces Lymph Flow and Diminishes Lipid Transport in Thoracic Duct‐Cannulated Rats

“…1). Numerous studies suggest that dietary guar gum inhibits absorption of lipid-soluble compounds such as cholesterol [1][2][3], lutein [4], canthaxanthin [4], a-tocopherol [4], 1,1,2-trichloroethylene [5], and 2,3,7,8tetrachlorodibenzo-p-dioxin [6]. One of the characteristics of guar gum is that it is a non-specific absorption inhibitor of any type of lipid-soluble compound.…”