Guaraná (Paullinia cupana Kunth) effects on LDL oxidation in elderly people: an in vitro and in vivo study

Portella, Rafael de Lima; Barcelos, Raquel Cristine Silva; Rosa, Edovando José Flores da; Ribeiro, Euler Esteves; Cruz, Ivana Beatrice Mânica da; Suleiman, Leila; Soares, Félix Alexandre Antunes

doi:10.1186/1476-511x-12-12

Cited by 58 publications

(46 citation statements)

References 33 publications

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“…The segregation pattern of two of these blocks combined explained 15% of the variability of this phenotypic characteristic when the plants were evaluated under short days. One of the loci-HVM40-is a complex repeat block consisting of (GA) 6 (GT) 4 (GA) 7 , while the other is composed of ATs [49] [50], such as GRN07 and part of GRN13 from the guarana plants. Combinations among other of those loci in barley explained more than 30% of the variability in the time necessary for flowering [49] [50].…”

Section: Resultsmentioning

confidence: 99%

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Microsatellites and the Polyploid Guarana Plant: Diversity under a Sea of Alleles

Angelo

Lira²,

Amado³

et al. 2014

OJGen

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Repeat blocks, microsatellites or simple sequence repeats (SSRs) can produce good co-dominant molecular markers for genetic diversity analysis and the determination of self-pollination rates in progenies originating from open pollination of selected genotypes. The enrichment of guarana genomic libraries was underway when it was confirmed that we are working with a complex polyploid species with 210 chromosomes. The probes (CA) 12 , (CT) 12 and (TC) 14 were used to finish the enrichment of four libraries for repeat blocks and the screening of a databank of expressed sequence tags (ESTs) from guarana seeded-fruits was accomplished as well. Fifteen clonal cultivars were genotyped with three replicas at 10 out of 27 identified loci using the 59 alleles that passed the reproducibility criterion. A large number of short repeat blocks were identified and this was considered to be a consequence of the recent polyploidization event. However, blocks with eight or more repeats ideal for genotyping were scarce. Annealing of most probes to short blocks by partial complementarity could explain the scarcity of longer blocks in genomic libraries but cannot explain why they were rare in the ESTs. Due to the complexity of the genotypes, alleles were treated as dominant traits. ESTs harboring repeat blocks had the functional annotation renewed. Locus GRN07 is inserted in a homologue of the MOTHER OF FLOWERING LOCUS T AND TFL1 (MFT), in which 3'-UTR displays clear post-transcriptional regulatory features. MFT and its variants are probably involved in the determination of seed germination and embryo growth characteristics. Other accessed loci can be involved in plant architecture and defense reactions. It was concluded that the alleles described in the present work can be used to distinguish guarana culti-* Corresponding author. P. C. S. Angelo et al. 191 vars and possibly to analyze segregation using the progenies of controlled pollinations between divergent genitors. Also, the fingerprints obtained can be added to the morphological and agronomic descriptors of the cultivars.

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Section: Resultsmentioning

confidence: 99%

“…This and the other biological properties of guarana, e.g. anti-tumorigenic activity, have been the targets for recent investigation [4]- [6].…”

Section: Introductionmentioning

confidence: 99%

Microsatellites and the Polyploid Guarana Plant: Diversity under a Sea of Alleles

Angelo

Lira²,

Amado³

et al. 2014

OJGen

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“…Moreover, it possesses free radical-scavenging and antioxidant activities, as analyzed by the diphenylpicrylhydrazyl (DPPH) assay, the β-carotene-linoleic acid system, and the relative antioxidant capacity (RAC) assay (Portella et al, 2013;Dalonso et al, 2012;Majhenic et al, 2007;Yamaguti-Sasaki et al, 2007), and it protects against cadmium-induced damage (Leite et al, 2011). Guaraná extract has an antioxidant effect on nitric oxide (NO) metabolism in situations with higher cellular NO levels (Bittencourt et al, 2013).…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Low toxicity Vermaak (2011), Mello (2010a, , Santa Maria (1998), Mattei (1998), andFonseca (1994) Antioxidant activity Bittencourt (2013), Portella (2013), Dalonso (2012), Majhenic (2007), Mendes and Carlini (2007), Yamaguti-Sasaki (2007), Basile (2005), and Mattei (1998) Antibacterial and antifungal activities Basile (2013Basile ( , 2005, Majhenic (2007), Yamaguti-Sasaki (2007) Antidepressive, anxiolytic and antiamnesic effects Roncon (2011), Shahwar (2010, Antonelli (2007), Majhenic (2007), Otobone (2005Otobone ( , 2007, , Basile (2005), Espinola (1997), and Mattei (1998) Chemoprophylactic in carcinogenesis and antigenotoxic activity Fukumasu (2011Fukumasu ( , 2008Fukumasu ( , 2006a, Oliveira ( , 2011, Leite (2011);Cragg (2006), and Espinola (1997) Inhibition of platelet aggregation Bydlowski (1991Bydlowski ( , 1988) Protection against gastric lesions Campos (2003) Lower risk of obesity, hypertension and metabolic syndrome Krewer (2011) Antifatigue effects Campos (2011) The seeds of Guaraná also contain acylglycerols and cyanolipids (Figure 3), an unusual class of plant lipids restricted to only a few families, such as Sapindaceae, Hippocastanacaeae and Boraginaceae (Moller and Seigler, 1999). The study of the oil from P. cupana Kunth var.…”

Section: Activity Referencementioning

confidence: 99%

Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

Hamerski¹,

Somner²,

Tamaio³

2013

J. Med. Plants Res.

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In Western markets, the extract from the seeds of Paullinia cupana Kunth, Sapindaceae, popularly known as Guaraná, is most commonly used in high-energy foods and drinks and dietary supplements. However, a broad spectrum of medicinal activities is reported for P. cupana, ranging from stimulation of the central nervous system, in cases of physical or mental stress, to appetite suppression. It can also be used as an aphrodisiac and a treatment for impotence, as well as a medication to reduce fever, stimulate metabolism, induce antiplatelet, antioxidant and antibacterial activites. In addtition, P. cupana has been used in cosmetic preparations, and it has become a popular soft drink in Brazil. In the last two decades, Guaraná has emerged as a key ingredient in various sports and high-energy drinks. Methylxanthines, including caffeine, cathechins, theophylline and theobromine, and tannins are compounds which are reported for this plant. This article reviews the most up-to-date information on the botanical, chemical and pharmacological aspects of P. cupana extract, as well as its miscellaneous uses.

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“…sorbilis (Mart.) Ducke, is a rainforest vine that is widely used in traditional (Mendes and Carlini, 2007) and clinical medicine (de Oliveira Campos et al, 2011;Rodrigues et al, 2012b;Portella et al, 2013). Besides, the extracts from roasted guarana seeds are used for the production of non-alcoholic energy drinks (McLellan and Lieberman, 2012).…”

Section: Introductionmentioning

confidence: 99%

Method for obtaining high-resolution proteomic analysis from pericarps of guarana

Souza¹,

Angelo²,

Nogueira³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Guarana has great agricultural potential and is largely used therapeutically and in the production of non-alcoholic energy drinks. Genomic and proteomic studies are crucial to identify proteins that play central roles in the maintenance and viability of fruits, as well as to identify proteins related to the main metabolic pathways. However, the success of any protein analysis starts with the protein extract preparation, which needs to offer an extract that is free of contaminants. This study aimed to evaluate different extraction methods to obtain high-quantity and high-quality extracts that are compatible with analysis by 2-dimensional electrophoresis and tandem mass spectrometry protein identification. Three different methods were tested: trichloroacetic acid (TCA)/acetone, sodium dodecyl sulfate (SDS)/phenol, and polyvinylpolypyrrolidone (PVPP)/SDS/phenol. The extract obtained from the TCA/acetone precipitation presented low solubility and contamination with lipids and carbohydrates. On the Protein extraction from Paullinia cupana other hand, the quality of the extract gradually improved after using phenol and PVPP/phenol, enabling a yield up to 2 mg/g macerated tissues and the detection of 457 spots by 2-dimensional electrophoresis. The effectiveness of the procedure used was validated by identification of 10 randomly selected proteins by mass spectrometry. The procedure described here can be a starting point for applications using tissues of other organs of guarana or tissues of species that are similar to guarana.

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Guaraná (Paullinia cupana Kunth) effects on LDL oxidation in elderly people: an in vitro and in vivo study

Cited by 58 publications

References 33 publications

Microsatellites and the Polyploid Guarana Plant: Diversity under a Sea of Alleles

Microsatellites and the Polyploid Guarana Plant: Diversity under a Sea of Alleles

Paullinia cupana Kunth (Sapindaceae): A review of its ethnopharmacology, phytochemistry and pharmacology

Method for obtaining high-resolution proteomic analysis from pericarps of guarana

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