Digital transformation, which significantly impacts our personal, social, and economic spheres of life, is regarded by many as the most significant development of recent decades. In an industrial context, based on a systematic literature review of 262 papers selected from the ProQuest database, using the methodology of David and Han, this paper discusses Industry 4.0 technologies as the key drivers and/or enablers of digital transformation for business practices, models, processes, and routines in the current digital age. After carrying out a systematic literature review considering key Industry 4.0 technologies, we discuss the individual and collective ways in which competitiveness in contemporary organizations and institutions is enhanced. Specifically, we discuss how these technologies contribute as antecedents, drivers, and enablers of environmental and social sustainability, corporate growth and diversification, reshoring, mass customization, B2B cooperation, supply chain integration, Lean Six Sigma, quality of governance, innovations, and knowledge related to dealing with challenges arising from global pandemics such as COVID-19. A few challenges related to the effective adoption and implementation of Industry 4.0 are also highlighted, along with some suggestions to overcome them.