Guías clínicas de la enfermedad de Chagas: Parte II. Enfermedad de Chagas en el adulto, la infancia y adolescencia

B, Werner Apt; G, Ingrid Heitmann; M, Leonor Jofré; V, Patricia Muñoz C. del; H, Isabel Noemí; V, Ana M San Martín; P, Jorge Sapunar; H, Marisa Torres; A, Inés Zulantay

doi:10.4067/s0716-10182008000300009

Cited by 8 publications

(14 citation statements)

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“…Infection with T . cruzi is globally recognized as the most common cause of acquired megacolon [ 51 ] and is the most frequent in Chile [ 52 ]. Consequently, when megacolon is detected, the probability of it being accurately reported as CD is better.…”

Section: Discussionmentioning

confidence: 99%

Spatio-temporal distribution of hospitalizations for chronic Chagas disease and risk factors associated with in-hospital mortality and surgical intervention in Chile

Atero,

Torres,

Domínguez

et al. 2024

PLoS Negl Trop Dis

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Chagas disease (CD) is a neglected parasitic zoonotic disease that affects over 6 million people worldwide. We conducted a retrospective study to analyze the spatiotemporal trends and risk factors for hospitalization rates of CD with cardiac and digestive diagnoses in Chile. We used the Mann-Kendall analysis for temporal trends, Global Moran’s Index, and Local Indicators of Spatial Association to identify spatial autocorrelation, and regression models to determine the risk factors associated with in-hospital mortality and surgical intervention. Between 2010 and 2020, a total of 654 hospitalizations were reported, corresponding to 527 individuals. The hospitalization rate steadily decreased over the years (t = -0.636; p = 0.009). The Global Moran’s I for the study period showed a positive spatial autocorrelation for hospitalization municipality and for residence municipality of CD patients (I = 0.25, p<0.001 and I = 0.45, p<0.001 respectively), indicating a clustering of hospitalizations in northern municipalities. The most frequent diagnosis was a chronic CD with digestive system involvement (55.8%) followed by a chronic CD with heart involvement (44.2%). The highest percentage of hospital discharges was observed among males (56.9%) and in the 60–79 age group (52.7%). In-hospital mortality risk was higher with increasing age (OR = 1.04), and in patients with cardiac involvement (OR = 2.3), whereas factors associated with the risk of undergoing a surgical intervention were sex (OR = 1.6) and diagnosis of CD with digestive involvement (OR = 4.4). The findings of this study indicate that CD is still a significant public health burden in Chile. Efforts should focus on improving access to timely diagnoses and treatment, reducing disease progression and hospitalization burden, and supporting clinicians in preventing complications and deaths.

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Section: Discussionmentioning

confidence: 99%

Spatio-temporal distribution of hospitalizations for chronic Chagas disease and risk factors associated with in-hospital mortality and surgical intervention in Chile

Atero,

Torres,

Domínguez

et al. 2024

PLoS Negl Trop Dis

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“…As manifestações sistêmicas que podem ocorrer incluem: febre, astenia, adinamia, mialgia, artralgia, cefaleia, miocardite e hepatoesplenomegalia. A miocardite pode ocorrer com ou sem manifestações de comprometimento cardíaco, como taquicardia, ritmo de galope, prolongamento do intervalo PR e/ou QT, diminuição da voltagem do QRS, contrações ventriculares prematuras, bloqueio de ramo direito, alterações da onda T, pericardite, tamponamento cardíaco e insuficiência cardíaca [70][71][72][73] .…”

Section: Fase Agudaunclassified

Avanços Na Compreensão Da Patogênese Da Doença De Chagas: Uma Abordagem Do Risco Cardiovascular

Freire Neto,

Barrera,

Castro

et al. 2024

Saúde Cardiovascular: Conhecimento, Prevenção E Cuidado

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“…La transmisión vectorial de la infección por T. cruzi ocurre cuando grandes cantidades del parásito presentes en las heces del vector infectado entran al cuerpo humano a través del sitio de la picadura, de la conjuntiva o de las membranas mucosas después de que este defeca mientras se alimenta o inmediatamente después (7,8). La transmisión también puede darse por transfusión, por trasplante de órganos, por infección de madre a hijo y por la vía oral debido a la ingestión de comida o de bebidas contaminadas, situación que recientemente ha cobrado relevancia en brotes de casos agudos (9)(10)(11).…”

Section: Detection Of Trypanosoma Cruzi Antibodies In Multitransfused Patients In Colombiaunclassified

Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia

et al. 2017

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Guías clínicas de la enfermedad de Chagas: Parte II. Enfermedad de Chagas en el adulto, la infancia y adolescencia

Cited by 8 publications

References 0 publications

Spatio-temporal distribution of hospitalizations for chronic Chagas disease and risk factors associated with in-hospital mortality and surgical intervention in Chile

Spatio-temporal distribution of hospitalizations for chronic Chagas disease and risk factors associated with in-hospital mortality and surgical intervention in Chile

Avanços Na Compreensão Da Patogênese Da Doença De Chagas: Uma Abordagem Do Risco Cardiovascular

Detection of Trypanosoma cruzi antibodies in multitransfused patients in Colombia

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