Guidance on the assessment of the safety of feed additives for the environment

Bampidis, Vasileios; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Kouba, Maryline; Durjava, Mojca Kos; López‐Alonso, Marta; Puente, Secundino López; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Brock, T.C.M.; Knecht, Joop de; Kolar, Boris; Beelen, Patrick van; Padovani, Laura; Tarrés‐Call, Jordi; Vettori, Maria Vittoria; Azimonti, Giovanna

doi:10.2903/j.efsa.2019.5648

Cited by 292 publications

(290 citation statements)

References 19 publications

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“…Over 50% of the operating costs in an intensive fish aquaculture are related to the fish feeding [46,47]. This led to research, in recent decades, for new sources of aquaculture nutrients, especially on terrestrial plants as legumes and oilseed crops [47][48][49].…”

Section: Fish Farmingmentioning

confidence: 99%

Seaweed Potential in the Animal Feed: A Review

Morais

Inácio

Coutinho

et al. 2020

JMSE

225

121

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Seaweed (known as marine algae) has a tradition of being part of the animal feed in the coastal areas, from ancient times. Seaweeds, are mixed with animal feed, because when consumed alone can have negative impact on animals. Thus, seaweeds are very rich in useful metabolites (pigments, carotenoids, phlorotannins, polyunsaturated fatty acids, agar, alginate and carrageenan) and minerals (iodine, zinc, sodium, calcium, manganese, iron, selenium), being considered as a natural source of additives that can substitute the antibiotic usage in various animals. In this review, we describe the nutritional values of seaweeds and the seaweed effects in the seaweed-based animal feed/supplements.

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Section: Fish Farmingmentioning

confidence: 99%

Seaweed Potential in the Animal Feed: A Review

Morais

Inácio

Coutinho

et al. 2020

JMSE

225

121

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“…The approach followed by the FEEDAP Panel to assess the safety and the efficacy of l ‐tryptophan is in line with the principles laid down in Regulation (EC) No 429/2008 and the relevant guidance documents: Guidance on studies concerning the safety of use of the additive for users/workers (EFSA FEEDAP Panel, ), Guidance on the identity, characterisation and conditions of use of feed additives (EFSA FEEDAP Panel, 2017c), Guidance on the characterisation of microorganisms used as feed additives or as production organisms (EFSA FEEDAP Panel, 2018a), Guidance on the assessment of the safety of feed additives for the target species (EFSA FEEDAP Panel, 2017d), Guidance on the assessment of the safety of feed additives for the consumer (EFSA FEEDAP Panel, 2017e), Guidance on the assessment of the efficacy of feed additives (EFSA FEEDAP Panel, 2018b) and Guidance for assessing the safety of feed additives for the environment (EFSA FEEDAP Panel, 2019f).…”

Section: Data and Methodologiesmentioning

confidence: 99%

Safety and efficacy of l‐tryptophan produced by fermentation using Escherichia coli CGMCC 7.267 for all animal species

Bampidis¹,

Azimonti²,

Bastos³

et al. 2020

EFS2

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with a genetically modified strain of Escherichia coli CGMCC 7.267 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain E. coli CGMCC 7.267 is safe for the production of l‐tryptophan. No viable cells or DNA of the production strain were detected in the additive under assessment. The use of l‐tryptophan produced using E. coli CGMCC 7.267 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non‐ruminant target species. However, excess doses would create amino acid imbalances with negative consequences on animal performance. The use of unprotected l‐tryptophan in feed poses safety concerns for ruminants. The use of l‐tryptophan produced by fermentation with E. coli CGMCC 7.267 in animal nutrition is considered safe for the consumers and for the environment. The endotoxin activity in the product and its dusting potential indicate an inhalation risk for the user. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin and eyes or to be a skin sensitiser. The additive l‐tryptophan produced using E. coli CGMCC 7.267 is regarded as an effective source of the amino acid l‐tryptophan. In order to be as efficacious in ruminants as in non‐ruminants, it should be protected from ruminal degradation.

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“…The efficacy B-Act ® for laying hens was established in the studies described above and that for chickens for fattening and turkeys for fattening was established in previous opinions (EFSA FEEDAP Panel, 2016, 2019a. Since the applicant proposes the use of the same level (1.6 9 10 9 CFU/kg complete feed) for minor poultry species for laying, poultry species for breeding purposes and for ornamental birds, the conclusions reached in laying hens and chickens and turkeys for fattening can be extended/extrapolated to these avian species/categories at the same use level.…”

Section: Efficacy For Laying Hensmentioning

confidence: 99%

Safety and efficacy of the feed additive consisting of Bacillus licheniformis DSM 28710 (B‐Act®) for laying hens, minor poultry species for laying, poultry species for breeding purposes and ornamental birds (HuvePharma N.V.)

Additives¹,

Bampidis²,

Azimonti³

et al. 2021

EFS2

Self Cite

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Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed ( FEEDAP ) was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of Bacillus licheniformis DSM 28710 (trade name: B‐Act ® ) when used in feed for laying hens, minor poultry species for laying and for breeding purposes and ornamental birds. B. licheniformis is considered suitable for the qualified presumption of safety ( QPS ) approach to safety assessment. The identity of the active agent was established, and it does not harbour acquired antimicrobial resistance genes or has toxigenic potential. Following the QPS approach, B. licheniformis DSM 28710 is presumed safe for the target species, consumers and the environment. Since no concerns are expected from the other components of the additive, B‐Act ® is also considered safe for the target species, consumers and the environment. No conclusions can be drawn on the skin/eye irritation or skin sensitisation potential of the additive, but B‐Act ® is considered a respiratory sensitiser. B‐Act ® when supplemented at 1.6 × 10 9 CFU /kg complete feed has the potential to be efficacious in laying hens. Considering also that the efficacy of the product was already shown in chickens and turkeys for fattening, the Panel concludes that the additive has the potential to be efficacious in minor poultry species for laying, poultry species for breeding purposes and for ornamental birds at the same inclusion level. The conclusions on the compatibility of B‐Act ® with coccidiostats previously drawn apply to the current application provided that the maximum authorised concentrations of the coccidiostats for the target species are equal or lower than those for chickens.

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Guidance on the assessment of the safety of feed additives for the environment

Cited by 292 publications

References 19 publications

Seaweed Potential in the Animal Feed: A Review

Seaweed Potential in the Animal Feed: A Review

Safety and efficacy of l‐tryptophan produced by fermentation using Escherichia coli CGMCC 7.267 for all animal species

Safety and efficacy of the feed additive consisting of Bacillus licheniformis DSM 28710 (B‐Act®) for laying hens, minor poultry species for laying, poultry species for breeding purposes and ornamental birds (HuvePharma N.V.)

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