Guided Treatment of Helicobacter pylori Infections with Non-Invasive PCR Tests—The Glory Days of Primary Care?

Abstract

Helicobacter pylori, a gram-negative bacterium that specifically colonizes gastric mucosa, is one of the most widespread infectious diseases in the world [...]

How Did We End Up Using a Quadruple Guided Therapy Combining At Least Two Antibiotics with a PPI to Eradicate Helicobacter pylori?

“…Coupled with recent discoveries in molecular microbiology in case of the validation of the genotypic-phenotypic linkage, this information should lead to a re-evaluation of the antibiotic therapy administered to patients according to the bacteriological diagnosis [ 12 ]. New technologies which assess the presence of subpopulations resistant to first-line antibiotics at a distance from the site of infection, without a need to multiply the number of associations deleterious to the microbial ecology, could also be of interest to, and entrusted by, general practitioners in order to optimize the management of this infection, which can lead to a lethal outcome if not managed effectively [ 13 , 14 , 15 ].…”