Guideline for diagnosis, prophylaxis and treatment of invasive fungal infection post burn injury in China 2013

Luo, Gaoxing; Tan, Jianglin; Peng, Yizhi; Wu, Jun; Huang, Yuesheng; Peng, Dan; Wang, Xu; Hu, Dahai; Xie, Songtao; Zhang, Guoan; Han, Chunmao; Huang, Xiaoyuan; Jia, Ciyu; Chai, Jiake; Huan, Jingning; Guo, Guang-hua; Zhan, Jie; Xie, Weiguo; Cen, Ying; Yu, Rong; Chen, Huade; Niu, Xihua; Wang, Yibing; Fu, Jinfeng; Xue, Baosheng

doi:10.4103/2321-3868.130182

Cited by 18 publications

(11 citation statements)

References 78 publications

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“…Furthermore, the treatment guidelines include infectious source control, rational use of antibiotics, continuous blood purification, application of glucocorticoids, immunomodulation, symptomatic and supportive treatment, and prevention of hospital-acquired infection. For burn invasive fungal infections, experts from the IBR and other 18 burn centers all over China composed the “Guideline for diagnosis, prophylaxis and treatment of invasive fungal infection post burn injury in China 2013” [ 32 ]. Host susceptibility, clinical manifestation, standardization of diagnosis, prevention, and treatment of fungal infection including surgical intervention are embodied.…”

Section: Reviewmentioning

confidence: 99%

The progress of Chinese burn medicine from the Third Military Medical University—in memory of its pioneer, Professor Li Ao

Zhou

Peng

et al. 2017

Burns &Amp; Trauma

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Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. The epidemiology and outcomes of admitted burn patients since 1958 were reviewed. Furthermore, main achievements of basic and clinical research for the past roughly 60 years were presented. These achievements mainly included the Chinese Rule of Nine, fluid resuscitation protocol, experience in inhalation injury, wound treatment strategies, prevention and treatment of burn infections, nutrition therapy, organ support therapies, and rehabilitation. The progress shaped and enriched modern Chinese burn medicine and promoted the development of world burn medicine.

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Section: Reviewmentioning

confidence: 99%

The progress of Chinese burn medicine from the Third Military Medical University—in memory of its pioneer, Professor Li Ao

Zhou

Peng

et al. 2017

Burns &Amp; Trauma

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“…This increase has been attributed to the human immunodeficiency virus (HIV) pandemic, medical and oncological therapeutic advances and the presence of better diagnostics for IFIs [ 2 ]. Other identified risk factors for IFI include malnutrition, severe burns, systemic corticosteroids for > 7 days, diabetes mellitus and multiple major surgery [ 3 , 4 ]. However the high morbidity and mortality from IFIs has been linked to delayed diagnosis and treatment, the development of resistance and the severity of illness [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of knowledge and awareness of invasive fungal infections amongst resident doctors in Nigeria

Oladele¹,

Otu²,

Olubamwo³

et al. 2020

Pan Afr Med J

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“…A recent Chinese large-scale, observational study of antifungal therapy in hematological diseases revealed that in 1401 patients undergoing hematopoietic stem cell transplantation (HSCT), the most common medications for invasive fungal diseases were triazoles (mainly fluconazole) and echinocandins [ 16 ] and a Chinese guideline for treatment of invasive fungal infection after burn injury recommends azoles and candins as first-line treatment for empirical therapies and excludes polyenes for prophylaxis [ 17 ]. Another guideline for the management of candidiasis from the Infectious Diseases Society of America (IDSA) recommends caspofungin and azoles as first-line treatments when azole resistance is unlikely [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Caspofungin in Unclassified Invasive Fungal Infection Cases: A Retrospective Analysis of Patients with Hematological Malignancies in China

Zhang

et al. 2018

Med Sci Monit

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BackgroundThe management of invasive fungal infection (IFI) is challenging in immunocompromised patients who do not fully satisfy the EORTC/MSG diagnostic criteria of proven or probable IFI. Our study assessed caspofungin efficacy in 582 Chinese patients with hematological malignancies exhibiting unclassified signs or symptoms of IFI.Material/MethodsThis retrospective study included caspofungin treatment outcomes of an unclassified group A (n=401) of patients without microbiological or biomarker results and group B (n=181) patients with positive microbiological or biomarker results. Factors that correlated with clinical outcomes were determined using univariate and multivariate analyses.ResultsCough (41.8%), expectoration (29.6%), and chest tightness (14.6%) were the most common clinical features, and changes in CT images (88.1%) were more frequently detected than in X-ray images (19.6%) in all patients. Favorable response rates for caspofungin as first-line treatment were 58.2% for group A and 56.3% for group B. Eastern Cooperative Oncology Group (ECOG) score, cardiovascular disease, hemoptysis, and absolute neutrophil count (ANC) <1000/mm3 before antifungal treatment without recovery were associated with unfavorable clinical outcome (P<0.05 for all). Cough and ANC recovery >1000/mm3 were significantly associated with favorable (complete or partial resolution) outcome.ConclusionsCaspofungin was effective for treating unclassified IFIs of immunocompromised patients. Cardiovascular disease, ECOG score, cough, and/or hemoptysis, as well as ANC count, represent a potential index for estimating response of unclassified IFI patients to caspofungin treatments.

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Guideline for diagnosis, prophylaxis and treatment of invasive fungal infection post burn injury in China 2013

Cited by 18 publications

References 78 publications

The progress of Chinese burn medicine from the Third Military Medical University—in memory of its pioneer, Professor Li Ao

The progress of Chinese burn medicine from the Third Military Medical University—in memory of its pioneer, Professor Li Ao

Evaluation of knowledge and awareness of invasive fungal infections amongst resident doctors in Nigeria

Efficacy of Caspofungin in Unclassified Invasive Fungal Infection Cases: A Retrospective Analysis of Patients with Hematological Malignancies in China

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