Guidelines for Imaging and Staging of Neuroblastic Tumors: Consensus Report from the International Neuroblastoma Risk Group Project

Brisse, H.; McCarville, M. Beth; Granata, Claudio; Krug, Kathrin Barbara; Wootton‐Gorges, Sandra L.; Kanegawa, Kimio; Giammarile, Francesco; Schmidt, Matthias; Shulkin, Barry L.; Matthay, Katherine K.; Lewington, Val; Sarnacki, Sabine; Hero, Barbara; Kaneko, Michio; London, Wendy B.; Pearson, Andrew D.J.; Cohn, Susan L.; Monclair, Tom

doi:10.1148/radiol.11101352

Cited by 433 publications

(354 citation statements)

References 60 publications

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“…Since then survival in LNESG1 related to INSS have been reported [6]. In 2005 the International Neuroblastoma Risk Group (INRG) Task Force, representing all major co-operative paediatric cancer groups, adopted the principle of surgical risk factors and incorporated it in the INRG Staging System [7,8]. The INRG Task Force preferred the term Image-Defined Risk Factors (IDRF) to surgical risk factors, and agreed upon a list of IDRF that was similar to the list used in this study (Table I) [5,7,8].…”

Section: Introductionmentioning

confidence: 99%

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Monclair

Mosseri

Cecchetto

et al. 2015

Pediatric Blood & Cancer

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BackgroundThe European multicenter study LNESG1 was designed to evaluate the safety and efficacy of surgical treatment alone in patients with localised neuroblastoma. In a retrospective, observational study we examined the impact of image‐defined risk factors (IDRF) on operative complications and survival (EFS and OS).Procedure534 patients with localised, non‐MYCN amplified neuroblastoma were recruited between 1995 and 1999. Group 1 consisted of 291 patients without IDRF (Stage L1 in the International Neuroblastoma Risk Group (INRG) staging system), all treated with primary surgery. Group 2: 118 patients with IDRF (INRG Stage L2), also treated with primary surgery. Group 3: 125 patients in whom primary surgery was not attempted, 106 receiving neo‐adjuvant chemotherapy.ResultsIn L1 patients (Group 1) 5‐year EFS was 92% and OS 98%. In L2 patients (Group 2 and 3) EFS was 79% and OS 89%. The differences in both EFS and OS were significant. EFS and OS in Group 2 (86% and 95%) were significantly better than 73% and 83% in Group 3. In INSS stage 1, 2 and 3, EFS were respectively 94%, 81% and 76%. Except between stage 2 and 3 the differences were significant. OS were respectively 99%, 93% and 83%, all significantly different. The 17% operative complication rate in L2 patients was significantly higher than 5% in L1 patients.ConclusionsIn localised neuroblastoma, IDRF at diagnosis are associated with worse survival rates and higher rates of operative complications. The impact of IDRF should become an integrated part of therapy planning. Pediatr Blood Cancer 2015;62:1536–1542. © 2015 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Monclair

Mosseri

Cecchetto

et al. 2015

Pediatric Blood & Cancer

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“…При выполнении визуализационных методов исследования врач-рентгенолог должен описать первичную опухоль, ее топографию и взаимосвязь с окружающими анатомическими структурами, а так-же указать в протоколе исследования факторы риска при визуализации (Image Defined Risk Factors, IDRF), наличие которых важно для выработки тактики веде-ния пациента [11].…”

Section: рис 6 визуализация 4s стадии нб с метастатическим поражениunclassified

“…Сцинтиграфия с МЙБГ обладает очень высокой чувствительностью и специфичностью (больше 90 % и 98 % соответственно) в диагностике метастатиче-ского поражения при НБ и поэтому рекомендована для использования в протоколах ведения пациентов с данным видом опухоли [11][12][13]. Однако из-за физио-логического накопления радиофармпрепарата (РФП) в паренхиме печени (рис.…”

Section: рис 6 визуализация 4s стадии нб с метастатическим поражениunclassified

Heterogeneity of neuroblastoma stage 4S: a multidisciplinary view

Шаманская¹,

Качанов²,

Feoktistova³

et al. 2017

Ross. ž. det. gematol. onkol.

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“…Following diagnosis, patients with neuroblastoma are stratified into low-, intermediate-, and high-risk groups, according to age, stage, and molecular pathology including amplification of the MYCN oncogene and the presence of segmental chromosomal abnormalities [3]. Staging and accurate assignment to a risk group is essential for predicting prognosis, and more importantly as a guide to the best available treatment [4,5].…”

mentioning

confidence: 99%

Semi-quantitative scoring of skeletal metastases by 123I-mIBG scintigraphy in high-risk neuroblastoma

Gaze

2017

Eur J Nucl Med Mol Imaging

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Guidelines for Imaging and Staging of Neuroblastic Tumors: Consensus Report from the International Neuroblastoma Risk Group Project

Cited by 433 publications

References 60 publications

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group

Heterogeneity of neuroblastoma stage 4S: a multidisciplinary view

Semi-quantitative scoring of skeletal metastases by 123I-mIBG scintigraphy in high-risk neuroblastoma

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