Guidelines for the diagnosis and management of recurrent urinary tract infection in women

Dason, Shawn; Dason, Jeyapandy T.; Kapoor, Anil

doi:10.5489/cuaj.11214

Cited by 137 publications

(136 citation statements)

References 62 publications

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“…A certain subset of individuals are affected by recurrent urinary tract infection, defined as ≥ 3 UTIs/year or ≥ 2 UTIs/6 months. 3 The relationship between nephrolithiasis and UTI is unclear. Traditionally, infectious stones were believed to be caused by urease-producing bacteria leading to the formation of struvite stones 3,4 .…”

Section: Introductionmentioning

confidence: 99%

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Does Stone Removal Help Patients with Recurrent Urinary Tract Infections?

et al. 2015

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Section: Introductionmentioning

confidence: 99%

“…3 The relationship between nephrolithiasis and UTI is unclear. Traditionally, infectious stones were believed to be caused by urease-producing bacteria leading to the formation of struvite stones 3,4 . However, recent studies demonstrate that 35% of stones associated with infection are calcium stones 4,5 .…”

Section: Introductionmentioning

confidence: 99%

Does Stone Removal Help Patients with Recurrent Urinary Tract Infections?

et al. 2015

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“…Antibiotic treatment is effective for managing an acute episode, but they do not prevent reinfection [5]. Similarly, continuous low-dose antibiotic prophylaxis is effective at preventing UTIs, but patients were found to revert to their previous frequency of UTI recurrence after discontinuing prophylaxis [23]. The worldwide rise of microbial resistance to first-line antibiotic therapies has led to treatment failure, forcing physicians to shift to new classes of antimicrobial agents [5,8,24].…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind, Parallel-Group, Multicenter Clinical Study of <b><i>Escherichia coli</i></b>-Lyophilized Lysate for the Prophylaxis of Recurrent Uncomplicated Urinary Tract Infections

Wagenlehner

Ballarini²,

Pilatz³

et al. 2015

Urol Int

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Background: One strategy for managing recurrent uncomplicated urinary tract infections (UTIs) is prevention. This study tested OM-89S, a lyophilized lysate of 18 Escherichia coli strains manufactured using a modified lytic process. Methods: This was a randomized, double-blind trial in 451 female subjects with recurrent uncomplicated UTIs. Period 1 of the study tested 6 mg of OM-89S versus placebo (3 months), plus a 3-month observation. Period 2 of the study was a 3-month treatment period (each monthly cycle consisted of 6 mg of OM-89S daily for 10 days and placebo for 20 days, vs. 50 mg nitrofurantoin daily for 30 days), plus a 3-month observation. Results: There was no difference in the mean rate of UTI episodes between the OM-89S (0.66 ± 0.93) and placebo groups (0.63 ± 0.86; p = 0.95) in period 1. Similar findings were obtained for period 2. OM-89S was well-tolerated. Conclusions: Our results did not demonstrate a preventive effect of OM-89S compared to placebo. This may be due to the low number of UTIs that occurred during the study, the high number of protocol violations, and/or the modified manufacturing process used for OM-89S.

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“…Recurrent UTIs are a major source of morbidity leading to repeated outpatient visits, antibiotic use, time lost from work, urological evaluations, and health care costs [4-7]. Factors that predispose to recurrent uncomplicated UTI include sexual activity, use of spermicidal agents, and a history of previous UTI [4-7].…”

Section: Introductionmentioning

confidence: 99%

“…Factors that predispose to recurrent uncomplicated UTI include sexual activity, use of spermicidal agents, and a history of previous UTI [4-7]. Due to an increased use of antibiotics, bacterial spectrum and antibiotic-resistance patterns in premenopausal women with recurrent UTIs are changing toward unfavorable resistance profiles [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Behavioral and Susceptibility Patterns in Premenopausal Women with Recurrent Urinary Tract Infections: A Case Control Study

Demour

Ababneh

2017

Urol Int

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Recurrent urinary tract infections (UTI) are a major source of morbidity and healthcare costs. Risk factors associated with recurrence rates in premenopausal women can be attributed to patient lifestyle behavior. The aim of this study was to assess hygienic risk factors, determine pathogen distribution, and susceptibility patterns in premenopausal women with recurrent UTI. This was case-control study in which a face-to-face interview was conducted to obtain information from premenopausal women with recurrent UTI. Microbiology cultures and susceptibility results were obtained to analyze pathogen distribution and resistance. In this study, 214 cases and 230 controls were compared and the following practices were associated with increased risk of recurrent UTI in multivariable analysis: washing genitals from back to front (OR 1.64 [95% CI 1.05–2.56]), not voiding within 15 min after intercourse (OR 2.81 [95% CI 1.72–4.66]), not drinking water after intercourse (OR 1.69 [95% CI 1.12–2.58]), using any soap to clean after urination (OR 2.11 [95% CI 1.42–3.17]). Escherichia coli were the most prevalent pathogens isolated (66.4%), followed by Klebsiella spp. (12.6%), Pseudomonas aeruginosa (12.1%), and Proteus spp., (6.6%). This study identified several modifiable sexual and hygienic practices associated with recurrent UTI in premenopausal women. Continuous surveillance of antimicrobial susceptibility patterns is important to overcome resistance.

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Guidelines for the diagnosis and management of recurrent urinary tract infection in women

Cited by 137 publications

References 62 publications

Does Stone Removal Help Patients with Recurrent Urinary Tract Infections?

Does Stone Removal Help Patients with Recurrent Urinary Tract Infections?

A Randomized, Double-Blind, Parallel-Group, Multicenter Clinical Study of <b><i>Escherichia coli</i></b>-Lyophilized Lysate for the Prophylaxis of Recurrent Uncomplicated Urinary Tract Infections

Evaluation of Behavioral and Susceptibility Patterns in Premenopausal Women with Recurrent Urinary Tract Infections: A Case Control Study

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