Guidelines for the management of Helicobacter pylori infection

Hunt, Claire L.

doi:10.1016/s0002-9270(98)00565-6

Cited by 37 publications

(16 citation statements)

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“…The relationship between peptic ulcers (both gastric and duodenal) and HP infection has been firmly established, while the exact relationship between HP infection and non-ulcer dyspepsia has not yet been clarified. A wide range of different national and international guidelines exists on how and when to diagnose and treat HP infections and different strategies have been proposed [1, 2, 3, 4, 5, 6]. The Maastricht consensus report, for example, recommends the testing and treating of HP infection based on age and symptoms, while other reports on dyspepsia management suggest testing and treating HP infection based on endoscopy [3, 7, 8].…”

Section: Introductionmentioning

confidence: 99%

Dyspepsia Management in Primary Care in The Netherlands: To What Extent Is Helicobacter pylori Diagnosis and Treatment Incorporated?

Weijnen

Wit²,

Numans³

et al. 2001

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Background: Many guidelines on the management of Helicobacter pylori (HP)-related dyspepsia have been launched over the past decade. The suggested policies in these guidelines are often more consensus- than evidence-based (test-and-treat policy, test and endoscope), which may cause confusion among primary-care physicians. Aim: To determine the current management of HP-related dyspepsia by Dutch general practitioners (GPs). Methods: A random sample of 5% of all Dutch GPs (n = 355) were sent a questionnaire on the diagnosis and treatment of HP infections in dyspepsia management. Results: The response rate was 66.2% (n = 235). Almost 80% of the responding GPs stated they had conducted HP testing (via endoscopy or serology) during the previous 12 months. In the same time period, more than 94% had actually prescribed a HP eradication therapy. A total of 70% of the GPs stated that they used endoscopy to test for HP infection, 54% used serology (ELISA); whole-blood tests and carbon urea breath tests were not used. Patients with a history of peptic ulcer disease, those on chronic acid-suppressive drugs and patients with recurrent ulcer-like complaints were most frequently tested for HP infection. Conclusions: Given the frequency of consultations for dyspepsia in primary care in the Netherlands (150 new dyspeptic patients per average practice per year), and the reported average number of HP tests perfomed (1–5 per GP per year), HP diagnosis plays a modest role in the management of dyspepsia in Dutch general practices. Neither the ‘test-and-treat’ policy recommended in the Maastricht guidelines, nor its advice regarding the choice of diagnostic tests (carbon urea breath test or serology), is being followed. The majority of GPs uses endoscopy for the detection of HP infection.

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Section: Introductionmentioning

confidence: 99%

Dyspepsia Management in Primary Care in The Netherlands: To What Extent Is Helicobacter pylori Diagnosis and Treatment Incorporated?

Weijnen

Wit²,

Numans³

et al. 2001

Digestion

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“…In fact, both UBT and stool antigen test are acceptable noninvasive test [16]. UBT has better performance, with a sensitivity of 88–95% and a specificity of 95%–100% [17]. It has also been proven that both 13C- (nonradioactive) and 14C-UBT (radioactive) are harmless in the pregnant female [18], with the possibility of the fetal radiation dose in the latter being much lower than the dose considered teratogenic [19].…”

Section: Discussionmentioning

confidence: 99%

The Utilization of a New Immunochromatographic Test in Detection ofHelicobacter pyloriAntibody from Maternal and Umbilical Cord Serum

Kuo

et al. 2014

BioMed Research International

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Background. Helicobacter pylori (H. pylori) was linked with several extragastrointestinal diseases, including preeclampsia and intrauterine growth restriction of fetus. One of the signals which can be transferred from mother to fetus is the H. pylori IgG antibody. Aims. We utilized a commercial immunochromatographic kit to detect the antibody in maternal and cord serum. Methods. Three hundred and forty-six females were enrolled and the blood samples were collected on antenatal examination and on delivery. The maternal H. pylori infection was determined by stool H. pylori antigen test. Results. One hundred and five females (30.3%) were H. pylori-infected, and the prevalence was higher in immigrants (43.5%) than in Taiwanese (28.7%, P = 0.058). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the kit were 77.1%, 88.0%, 73.6%, 89.8%, and 84.7%, respectively. This kit also had similar performance in cord serum. Comparing to the maternal result on delivery, this kit offered a consistent performance in antenatal maternal serum (kappa coefficient 0.92) and in cord serum (kappa coefficient 0.88). Conclusions. H. pylori IgG antibody can be transferred through the placenta into the fetal circulation. However, accuracy of the test kit needs to be evaluated before utilization in screening.

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“…Amoxicillin distributes to the liver, lungs, gallbladder, and prostate, where it can mildly elevate liver enzyme levels and produce jaundice and abnormalities of bile secretion. Liver injury is a rare side effect of amoxicillin treatment 10,11. Pathology evaluation is helpful for the diagnosis of drug-induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage

et al. 2011

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Amoxicillin, an antibiotic that is widely prescribed for various infections, is associated with a very low rate of drug-induced liver injury; hepatitis and cholestasis are rare complications. Here we present a case of a 39-year-old woman who was diagnosed with abdominal actinomycosis and received amoxicillin treatment. The patient displayed hepatocellular and bile-duct injury, in addition to elevated levels of liver enzymes. The patient was diagnosed with amoxicillin-induced cholestatic hepatitis. When amoxicillin was discontinued, the patient's symptoms improved and her liver enzyme levels reduced to near to the normal range.

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Guidelines for the management of Helicobacter pylori infection

Cited by 37 publications

References 0 publications

Dyspepsia Management in Primary Care in The Netherlands: To What Extent Is Helicobacter pylori Diagnosis and Treatment Incorporated?

Dyspepsia Management in Primary Care in The Netherlands: To What Extent Is Helicobacter pylori Diagnosis and Treatment Incorporated?

The Utilization of a New Immunochromatographic Test in Detection ofHelicobacter pyloriAntibody from Maternal and Umbilical Cord Serum

A case of amoxicillin-induced hepatocellular liver injury with bile-duct damage

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