A large number of metallic glasses (MGs) with high mechanical and functional performance that cannot be achieved by traditional metals in various alloy systems have been developed. At the same time, people realized that micro-and nanoscale wires can improve properties and extend functionality of bulk materials. Therefore, intensive effort has been made to fabricate micro-and nanoscale MG wires, and study their mechanical and physical behavior to achieve high performance. This article reviews fabrication, properties and applications of the wires, and presents technical and theoretical challenges, which must be tackled to achieve high-performance MG wire devices and understand physical mechanisms of mechanical and functional behaviors of the wires.