Guiding Global Best Practice in Personalized Nutrition Based on Genetics: The Development of a Nutrigenomics Care Map

Horne, Justine; Nielsen, Daiva E.; Madill, Janet; Robitaille, Julie; Vohl, Marie‐Claude; Mutch, David M.

doi:10.1016/j.jand.2021.02.008

Cited by 22 publications

(24 citation statements)

References 77 publications

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“…However, the current nutrition and dietetics curricula do not include courses related to advanced human genetics, such as discussions on omics technologies, interpretation of genetic variation information, and legal, ethical, and social aspects of genetic information (Kaufman-Shriqui et al 2020). Education and training for nutritionists and dietitians are relevant because the basic science and evidence surrounding nutritional genomics continue to progress, because clinical practice guidelines do not yet exist for gene-based nutrition advice (Horne et al 2021) and because the expectations for nutrition professionals are increasing as a response to the growing demand for genetic testing (Araujo Almeida et al 2019). Such training and continuing education in nutritional genomics will provide appropriate interpretation and clinical action based on the results of genetic testing (De et al 2019) and ensure confidence and competence among nutrition professionals (Horne et al 2021).…”

Section: Introductionmentioning

confidence: 99%

“Right diet for the right person”: a focus group study of nutritionist-dietitians’ perspectives on nutritional genomics and gene-based nutrition advice

et al. 2021

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Advances in nutritional genomics are intended to revolutionize nutrition practice. A basic understanding of nutritional genomics among nutritionist-dietitians is critical for such advancements to occur. As a precedent to the development and integration of gene-based nutrition advice, this study aimed to assess hospital-based nutritionist-dietitians’ perceptions of nutritional genomics. A total of ten focus group discussions (FGDs) with sixty-one registered nutritionist-dietitians (RNDs) from hospitals in the National Capital Region (NCR), Philippines, were conducted from October to November 2019. Data were collected using a pretested semistructured discussion guide, and thematic analysis was subsequently performed. Diverging perceptions about nutritional genomics were noted among the FGD participants. Five themes emerged relating to the enablers and barriers of gene-based nutrition advice: training and capacity building, the extent of information to be disclosed, cost, ethical considerations, and government support. Themes related to the desired features of the gene-based nutrition advice included being consent-driven, cost-effective, technology-oriented, and guided by standards. The results of this study suggest that training and continued learning will equip RNDs to provide nutrition advice based on genetic information. However, other factors, such as cost and ethical considerations, are critical dimensions that need to be acknowledged and addressed before integrating gene-based advice into nutrition practice.

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Section: Introductionmentioning

confidence: 99%

“Right diet for the right person”: a focus group study of nutritionist-dietitians’ perspectives on nutritional genomics and gene-based nutrition advice

et al. 2021

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“…Furthermore, if a genetic test lacks clinical (including scientific) validity, there is typically little need to proceed with assessing other aspects of utility/validity as there is insufficient evidence to support the particular test for clinical use ( 44 ). In addition, a care map, which outlines step-by-step directions for the appropriate integration of nutrigenetic testing into clinical practice, has been developed ( 3 ). This provides a broad overview of factors to consider to promote ethical and evidence-based practice in the field ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a care map, which outlines step-by-step directions for the appropriate integration of nutrigenetic testing into clinical practice, has been developed ( 3 ). This provides a broad overview of factors to consider to promote ethical and evidence-based practice in the field ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…This is a field that explores the interplay between genetics and nutrition, and their subsequent impact on health-related outcomes ( 2 ). While this science is applied to clinical practice and more broad guidance for clinicians has been published ( 3 , 4 ), there is considerable debate about whether the use of nutrigenetic tests have sufficient scientific validity to be supported ( 5 , 6 ). In order to resolve this debate, there is a clear need to determine the quality of evidence (scientific validity) of the various nutrigenetic tests and their clinical claims.…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics

et al. 2021

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Background: There is a significant lack of consistency used to determine the scientific validity of nutrigenetic research. The aims of this study were to examine existing frameworks used for determining scientific validity in nutrition and/or genetics and to determine which framework would be most appropriate to evaluate scientific validity in nutrigenetics in the future.Methods: A systematic review (PROSPERO registration: CRD42021261948) was conducted up until July 2021 using Medline, Embase, and Web of Science, with articles screened in duplicate. Gray literature searches were also conducted (June-July 2021), and reference lists of two relevant review articles were screened. Included articles provided the complete methods for a framework that has been used to evaluate scientific validity in nutrition and/or genetics. Articles were excluded if they provided a framework for evaluating health services/systems more broadly. Citing articles of the included articles were then screened in Google Scholar to determine if the framework had been used in nutrition or genetics, or both; frameworks that had not were excluded. Summary tables were piloted in duplicate and revised accordingly prior to synthesizing all included articles. Frameworks were critically appraised for their applicability to nutrigenetic scientific validity assessment using a predetermined categorization matrix, which included key factors deemed important by an expert panel for assessing scientific validity in nutrigenetics.Results: Upon screening 3,931 articles, a total of 49 articles representing 41 total frameworks, were included in the final analysis (19 used in genetics, 9 used in nutrition, and 13 used in both). Factors deemed important for evaluating nutrigenetic evidence related to study design and quality, generalizability, directness, consistency, precision, confounding, effect size, biological plausibility, publication/funding bias, allele and nutrient dose-response, and summary levels of evidence. Frameworks varied in the components of their scientific validity assessment, with most assessing study quality. Consideration of biological plausibility was more common in frameworks used in genetics. Dose-response effects were rarely considered. Two included frameworks incorporated all but one predetermined key factor important for nutrigenetic scientific validity assessment.Discussion/Conclusions: A single existing framework was highlighted as optimal for the rigorous evaluation of scientific validity in nutritional genomics, and minor modifications are proposed to strengthen it further.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=261948, PROSPERO [CRD42021261948].

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“…Regulation of nutrition is capable to change the state of health of the body [2]. Personal nutrition takes into account the entirety of the individual consumer's characteristics, helps prevent the development of a range of chronic diseases, and therefore it features prophylactic function [3,4]. The general goal of the authors' research is to form an integrated approach to nutrition, including the selection of personal dietary recommendations and the development of individual functional food products (FFP) and biologically active additives (BAA) to prevent diseases [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The methodology of food design. Part 2. Digital nutritiology in personal food

Prosekov

Vesnina

Kozlova

2022

Teor. prakt. pererab. mâsa (Print)

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Atherosclerosis (the main cause of a wide range of cardiovascular diseases) and other multifactorial diseases depend on several nutrition factors, defined in general by lifestyle that directly and constantly affects the human body. The modern level of science and technology development is able to form a diet, taking into account all personal characteristics in such a way that makes nutrition an effective preventive measure against diseases in order to keep a person healthy. The purpose of this article is to define and study all the limitations (the scope of its coverage in the scientific literature) that arose in the process of research aimed to formation of an integrated personal approach to designing of nutrition to prevent atherosclerosis. The object of the study was scientific literature, which is available in open source and free access databases: PubMed, ScienceDirect, eLIBRARY.RU, www.fips.ru, Patentscope. The language of search is Russian and English, search depth is 12 years. In the course of the research two food design concepts were found that affect process of digitalization in the food sector: the concept “FoodTech” (food technology) and digital nutritiology. It was established that in Russia only one company — LLC “City Supermarket” (Moscow), that works with the brand “Azbuka Vkusa” — acts in the sphere of “FoodTech” on the Russian market. This company selects personalized food, taking into account the results of personal nutrigenetic tests, in cooperation with LLC “Genotech” (Moscow). There is a need to use biological information, statistical information processing (nutrigenetic studies, nutrigenomic research) and machine-aided data processing (machine learning) for further generation of automatic algorithm that compiles personal recommendations. The relevance of generation of a national domestic database on chemical composition of food products (presented in the market) to simplify the preparation of individual personal diets is observed. We underline the necessity to use the test-organisms, i. e. dorio fish / zebrafish (Danio rerio) and nematodes (Caenorhabditis elegans)), which were used to determine the activity of candidate substances — the biologically active substances that feature antiatherosclerotic properties. In the future the authors plan to conduct a nutrigenomic and nutrigenetic study, using digital achievements. To collect information about consumers, it is necessary to apply digital devices, and use biological informatics to process the results; after that it is necessary to generate the algorithm for automatic selection of personalized dietary recommendations.

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Guiding Global Best Practice in Personalized Nutrition Based on Genetics: The Development of a Nutrigenomics Care Map

Cited by 22 publications

References 77 publications

“Right diet for the right person”: a focus group study of nutritionist-dietitians’ perspectives on nutritional genomics and gene-based nutrition advice

“Right diet for the right person”: a focus group study of nutritionist-dietitians’ perspectives on nutritional genomics and gene-based nutrition advice

A Systematic Review and Recommendations Around Frameworks for Evaluating Scientific Validity in Nutritional Genomics

The methodology of food design. Part 2. Digital nutritiology in personal food

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