Guillain-Barre Syndrome and Antibodies to Arboviruses (Dengue, Chikungunya and Japanese Encephalitis)

Abstract

Objective: The aim of this study was to detect the presence of IgM antibodies against dengue (DEN), chikungunya (CHIK) and Japanese encephalitis (JE) in the serum and CSF of patients with Guillaine-Barre syndrome (GBS). Methods: GBS patients (>12 years of age) were included after informed consent. Data on history, clinical manifestations, treatment details, and outcome were collected. Serum and CSF were tested for IgM antibodies against DEN, CHIK, and JE. Results: From April 2018 to December 2019, 95 patients were included in this study. Anti-arboviral IgM antibodies were detected in 30 patients (31.5%) (CSF 11, serum 13, both CSF and serum 6). Serum IgM antibody was present in 19 patients (JE 8, DEN 5, CHIK 2, more than 1 virus 4). Of the 66 patients who underwent CSF studies, antibodies were present in 17 (CHIK 14, DEN 1, more than 1 virus 2). Antibody positivity did not affect the outcome of GBS. Conclusion: One-third of the GBS patients had evidence of recent infection by arboviruses. This suggests that DEN, CHIK, and JE could be the inciting event for GBS in endemic regions.

Pulmonary Cavitation as a Complication of COVID-19: Case Series and a Brief Review of the Literature

“…The bacterial culture showed the presence of Klebsiella pneumoniae, which was resistant to all antibiotics except for fosfomycin, while the fungal culture did not yield any results. A retrospective study by Amalnath et al [30] showed that 22 patients developed large cavities 2 to 4 weeks after experiencing symptoms. None of these patients were on mechanical ventilation, but 18 of them died within a few days of discovering the cavities.…”

Peripheral Nerve Injury Induced by Japanese Encephalitis Virus in C57BL/6 Mouse

“…GBS is the most frequent cause of acute flaccid paralysis worldwide and is often preceded by an infectious disease. Flavivirus infections are also responsible for a significant number of GBS patients, especially in highly endemic countries ( 36 – 38 ). However, GBS is rarely reported after JEV infection and is limited to case reports.…”

Associação Da Síndrome De Guillain-Barré Com Arboviroses

“…A Síndrome de Guillain-Barré (SGB) define-se como uma polirradiculopatia imunomediada caracterizada por um quadro de paralisia ascendente arreflexa podendo evoluir, com pior prognóstico, para fraqueza muscular respiratória. (Pari et al, 2022). Nesse contexto, um extenso conjunto de evidências inferidas respalda a natureza autoimune da síndrome.…”