?-gulonolactone oxidase activity and vitamin C status in riboflavin-deficient rats

Kiuchi, Kazutoshi; Nishikimi, Morimitsu; Yagi, Kunio

doi:10.1016/0304-4165(80)90281-0

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…In addition, the in ovo injection of 12 mg of L-AA resulted in the highest eye L-AA concentrations in the current study. The production of L-AA has been shown to be limited by decreased levels of L-gulonolactone oxidase activity [ 53 ]. Therefore, Kuo et al [ 52 ] concluded that the noted differences could be due to differences in the level of expression of gulonolactone oxidase in various tissues of the organism.…”

Section: Discussionmentioning

confidence: 99%

Effects of the In Ovo and Dietary Supplementation of L-Ascorbic Acid on the Growth Performance, Inflammatory Response, and Eye L-Ascorbic Acid Concentrations in Ross 708 Broiler Chickens

Mousstaaid

Fatemi

Elliott

et al. 2022

Animals

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Effects of the dietary and in ovo administration of L-ascorbic acid (L-AA) on the performance, plasma nitric oxide, and eye L-AA concentrations of Ross 708 broilers were investigated. At 17 days of incubation, live embryonated hatching eggs were randomly assigned to a non-injected or sham-injected (100 μL of saline) control group, or a group injected with either 12 or 25 mg of L-AA suspended in 100 μL of saline. Chicks received a commercial diet with or without 200 mg/kg of supplemental L-AA and were randomly assigned to each of 6 replicate floor pens in each in ovo injection-dietary treatment combination. Weekly live performance variables through 14 days of post hatch age (doa) and the eye weights in both sexes at 0, 7, and 14 doa were determined. At 0 and 14 doa, plasma nitric oxide levels and eye L-AA concentrations of one bird of each sex in each pen were determined. Dietary supplemental L-AA decreased feed intake and growth between 0 and 7 doa, but from 8 to 14 doa; all birds fed supplemental L-AA had a lower feed conversion ratio. At 14 doa, male chicks had higher eye L-AA concentrations and lower plasma nitric oxide levels when treated in ovo with 12 mg of L-AA. In conclusion, dietary L-AA may be used to improve feed conversion in the second week of broiler post hatch growth. However, the in ovo administration of 12 mg of L-AA can increase male eye L-AA concentrations and is effective in reducing their general inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Effects of the In Ovo and Dietary Supplementation of L-Ascorbic Acid on the Growth Performance, Inflammatory Response, and Eye L-Ascorbic Acid Concentrations in Ross 708 Broiler Chickens

Mousstaaid

Fatemi

Elliott

et al. 2022

Animals

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“…Once transferred, electrons can migrate within the heterocyclic isoalloxazine ring. 3 Abbreviations used: ABCG2, ATP-binding cassette transporter G2; ALS, amyotrophic lateral sclerosis; CNS, central nervous system; CPR, NAD(P)H-cytochrome P450 reductase; CTX, cerebrotendinous xanthomatosis; CYP, cytochrome P450; DHCR7, 7-dehydrocholesterol reductase; DHCR24, 24-dehydrocholesterol reductase; ETF, electron transferring flavoprotein; FGF-23, fibroblast growth factor-23; FLX1, flavin exchange protein; HMG-CoA, 3-hydroxy-3-methylglutaryl-coenzyme A; K m , Michaelis constant; LSS, lanosterol synthase (squalene-2,3-oxide lanosterol cyclase); MFT, mitochondrial folate transporter; 1a,25(OH) 2 D, 1a,25-dihydroxyvitamin D; 25(OH)D, 25-hydroxyvitamin D.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

“…Flavins also assist in the catalytic activation and degradation of other vitamins. For example, flavoenzymes affect de novo biosynthesis of ascorbic acid (2,3), control the conversion of pyridoxine and vitamin K to their physiologically active forms (4-7), protect vitamins from oxidative degradation (8)(9)(10), and function conjointly with other vitamin-dependent enzymes, e.g., pyruvate dehydrogenase complex and respiratory chain complexes (11). Such interactions are the basis for the interdependency among vitamins and an underlying cause of secondary vitamin deficiencies.…”

Section: Introductionmentioning

confidence: 99%

“…This results in conversion of provitamin D 3 (7-dehydrocholesterol) to a previtamin D 3 (6-s-cis form), which undergoes a thermally induced E/Z isomerization to form 6-s-trans, cholecalciferol (12). Both ergocalciferol and cholecalciferol must be converted into physiologically active vitamin D metabolites through 2 separate ring hydroxylations with subsequent formation of 1a,25dihydroxyvitamin D [1a,25(OH) 2 D] 3 . Current investigations in healthy individuals with negligible UV-B exposure suggest that ergocalciferol and cholecalciferol are equipotent in their capacity to be 25-hydroxylated to form 25-hydroxyvitamin D [25(OH)D], the major circulating form of vitamin D (13,14).…”

Section: Introductionmentioning

confidence: 99%

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From Cholesterogenesis to Steroidogenesis: Role of Riboflavin and Flavoenzymes in the Biosynthesis of Vitamin D

Pinto

Cooper

2014

Advances in Nutrition

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Flavin-dependent monooxygenases and oxidoreductases are located at critical branch points in the biosynthesis and metabolism of cholesterol and vitamin D. These flavoproteins function as obligatory intermediates that accept 2 electrons from NAD(P)H with subsequent 1-electron transfers to a variety of cytochrome P450 (CYP) heme proteins within the mitochondria matrix (type I) and the (microsomal) endoplasmic reticulum (type II). The mode of electron transfer in these systems differs slightly in the number and form of the flavin prosthetic moiety. In the type I mitochondrial system, FAD-adrenodoxin reductase interfaces with adrenodoxin before electron transfer to CYP heme proteins. In the microsomal type II system, a diflavin (FAD/FMN)-dependent cytochrome P450 oxidoreductase [NAD(P)H-cytochrome P450 reductase (CPR)] donates electrons to a multitude of heme oxygenases. Both flavoenzyme complexes exhibit a commonality of function with all CYP enzymes and are crucial for maintaining a balance of cholesterol and vitamin D metabolites. Deficits in riboflavin availability, imbalances in the intracellular ratio of FAD to FMN, and mutations that affect flavin binding domains and/or interactions with client proteins result in marked structural alterations within the skeletal and central nervous systems similar to those of disorders (inborn errors) in the biosynthetic pathways that lead to cholesterol, steroid hormones, and vitamin D and their metabolites. Studies of riboflavin deficiency during embryonic development demonstrate congenital malformations similar to those associated with genetic alterations of the flavoenzymes in these pathways. Overall, a deeper understanding of the role of riboflavin in these pathways may prove essential to targeted therapeutic designs aimed at cholesterol and vitamin D metabolism.

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Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: Achievements and unsolved problems

Медведев

Veselovsky

Fedchenko

2010

Biochemistry Moscow

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Renalase is a recently discovered secretory enzyme responsible for selective degradation of blood catecholamines. The review summarizes literature data on expression of this enzyme and on its structure and functions. Special attention is paid to unsolved and questionable problems including: 1) prediction of the presence of FAD in the protein structure based on amino acid sequence similarity of renalase with known FAD-dependent enzymes; 2) identity of plasma and urinary renalase; 3) mechanism underlying conversion of inactive renalase into the active form.

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?-gulonolactone oxidase activity and vitamin C status in riboflavin-deficient rats

Cited by 4 publications

References 10 publications

Effects of the In Ovo and Dietary Supplementation of L-Ascorbic Acid on the Growth Performance, Inflammatory Response, and Eye L-Ascorbic Acid Concentrations in Ross 708 Broiler Chickens

Effects of the In Ovo and Dietary Supplementation of L-Ascorbic Acid on the Growth Performance, Inflammatory Response, and Eye L-Ascorbic Acid Concentrations in Ross 708 Broiler Chickens

From Cholesterogenesis to Steroidogenesis: Role of Riboflavin and Flavoenzymes in the Biosynthesis of Vitamin D

Renalase, a new secretory enzyme responsible for selective degradation of catecholamines: Achievements and unsolved problems

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